[PDF] Top 20 Latency-Associated Nuclear Antigen (LANA) of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Origin Recognition Complexes at the LANA Binding Sequence within the Terminal Repeats
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Latency-Associated Nuclear Antigen (LANA) of Kaposi's Sarcoma-Associated Herpesvirus Interacts with Origin Recognition Complexes at the LANA Binding Sequence within the Terminal Repeats
... T antigen, papil- lomavirus E1, and origin binding proteins of herpes simplex virus type 1, LANA and EBNA1 sequence analysis did not reveal the presence of any motif associated ... See full document
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Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Recruits Uracil DNA Glycosylase 2 at the Terminal Repeats and Is Important for Latent Persistence of the Virus
... Latency-associated nuclear antigen (LANA) of KSHV is expressed in all forms of Kaposi’s sarcoma- associated herpesvirus (KSHV)-mediated tumors and is important for ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Interacts with Bromodomain Protein Brd4 on Host Mitotic Chromosomes
... also interacts with KSHV ...KSHV LANA, is required for episome main- tenance. The C terminus of LANA contributes the major bind- ing site for Brd4, whereas the highly acidic central repeats of ... See full document
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The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Permits Replication of Terminal Repeat-Containing Plasmids
... that LANA, like EBNA-1, can mediate DNA replication of plasmids bearing copies of its DNA-binding site; the two proteins also share secondary struc- tural ...by LANA in cells of epithelial and ... See full document
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A Domain in the C-Terminal Region of Latency-Associated Nuclear Antigen 1 of Kaposi's Sarcoma-Associated Herpesvirus Affects Transcriptional Activation and Binding to Nuclear Heterochromatin
... of sequence between aa 1129 and 1143, AGNLQSSIVKFKKPL, contains two serine and three lysine residues, putative targets, respectively, for phosphorylation, ubiquitinylation, and ...their nuclear ... See full document
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Latency-Associated Nuclear Antigen Encoded by Kaposi's Sarcoma-Associated Herpesvirus Interacts with Tat and Activates the Long Terminal Repeat of Human Immunodeficiency Virus Type 1 in Human Cells
... that LANA at least partially transactivates the promoter by means other than signaling through the NF-IL6, Ets-1, NFB, or Sp1 ...that LANA affects the basal transcrip- tional machinery in cooperation with ... See full document
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Determination of Kaposi's Sarcoma-Associated Herpesvirus C-Terminal Latency-Associated Nuclear Antigen Residues Mediating Chromosome Association and DNA Binding
... C-terminal LANA contains a chromosome association function. C-terminal LANA concentrates at peri- centromeric and peritelomeric regions of a subset of mitotic chromosomes ...C-terminal ... See full document
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DNA Binding and Modulation of Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s ...The latency-associated ... See full document
11
Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Recruits Topoisomerase IIβ for Latent DNA Replication of the Terminal Repeats
... The latency-associated nuclear antigen (LANA) encoded by Kaposi’s sarcoma-associated herpesvirus (KSHV) plays a major role in maintaining latency and is ... See full document
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Protein Interactions Targeting the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus to Cell Chromosomes
... Kaposi’s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8), is associated with all forms of Kaposi’s sarcoma, primary effusion lymphoma (PEL), and some forms ... See full document
9
Regulation of the Interaction between Glycogen Synthase Kinase 3 and the Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen
... to LANA-mediated dysregulation of  -catenin is the binding of LANA to nuclear GSK-3 and consequent nu- clear accumulation and cytoplasmic depletion of ...of LANA contained a region ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Latency-Associated Nuclear Antigen Regulates the KSHV Epigenome by Association with the Histone Demethylase KDM3A
... aposi’s sarcoma-associated herpesvirus (KSHV), also desig- nated human herpesvirus 8 (HHV-8), has been linked to Ka- posi’s sarcoma (KS) as well as primary effusion lymphoma (PEL) (or ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Reactivation Is Regulated by Interaction of Latency-Associated Nuclear Antigen with Recombination Signal Sequence-Binding Protein Jκ, the Major Downstream Effector of the Notch Signaling Pathway
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is the major biological cofactor contributing to develop- ment of Kaposi’s ...the latency- associated nuclear antigen ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen: Replicating and Shielding Viral DNA during Viral Persistence
... of LANA speckles to mitotic chromatin (the CBS described above) (29, 39, ...of LANA was also shown to play a role in replication and transcriptional regulation (29, 74, 75) and contains a motif for the ... See full document
10
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induction by Hypoxia and Hypoxia-Inducible Factors
... with nuclear extracts (NE) from Hep3B cells cultured in 10-cm dishes in normoxia (N) or in hypoxia (H) for 16 h or transfected with 5 g degradation-resistant mutants of HIF-1 ␣ or HIF-2 ␣ for 48 ...assess ... See full document
12
The Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus Supports Latent DNA Replication in Dividing Cells
... primary sequence flanking the LBS for elements commonly found in eukaryotic origins of ...of herpesvirus saimiri and EBV (22, 33, 34, ...of LANA, we scanned the TR for AT-rich ...TR sequence ... See full document
11
Modulation of Cellular and Viral Gene Expression by the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus
... as LANA opened the door for studies addressing the function of this protein during ...Its nuclear localization and restriction to latency suggested that LANA was a formal analog of the ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded Latency-Associated Nuclear Antigen Modulates K1 Expression through Its cis-Acting Elements within the Terminal Repeats
... factor binding sites contribute signifi- ...factor binding sites in the ⫺ 116 to ⫹ 76 region of ...factor binding sequences I, II, and III. The top strand is the sequence in K1p and the bottom ... See full document
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Definition of Sequence Requirements for Latency-Associated Nuclear Antigen 1 Binding to Kaposi's Sarcoma-Associated Herpesvirus DNA
... and LANA mutants which cannot self-associate do not bind DNA, similar to ...LANA1 binding to DNA but not LANA1 ...EBNA1 sequence which directly contacts DNA but is not involved in dimerization ... See full document
6
Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Induces a Strong Bend on Binding to Terminal Repeat DNA
... of LANA and EBNA1 to bend origin DNA may be a necessary step in creating a specific platform capable of recruiting ORCs and associated replication initiation ... See full document
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