[PDF] Top 20 Binding of Kaposi's Sarcoma-Associated Herpesvirus K-bZIP to Interferon-Responsive Factor 3 Elements Modulates Antiviral Gene Expression
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Binding of Kaposi's Sarcoma-Associated Herpesvirus K-bZIP to Interferon-Responsive Factor 3 Elements Modulates Antiviral Gene Expression
... regulatory elements between these promoters might account for the observed ...endogenous gene expression, while Liao et ...studied K-bZIP repressive activity using IFN-  inducers ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus K-bZIP Is a Coregulator of K-Rta: Physical Association and Promoter-Dependent Transcriptional Repression
... that K-Rta is sufficient to induce lytic reactivation of the latent KSHV genome in the BCBL-1 cell line model for PEL (22, ...36). K-Rta is a potent transcriptional factor with an N-terminal putative ... See full document
11
Kaposi's Sarcoma-Associated Herpesvirus K-bZIP Protein Is Necessary for Lytic Viral Gene Expression, DNA Replication, and Virion Production in Primary Effusion Lymphoma Cell Lines
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of three human proliferative disorders, namely, Kaposi’s sarcoma, primary effusion lymphomas (PEL), and multicentric ... See full document
12
Kaposi's Sarcoma-Associated Herpesvirus K-bZIP Represses Gene Transcription via SUMO Modification
... KSHV gene expression program, including the immediate induction of K-bZIP ...of K-bZIP protein; ...fragments, associated with K-bZIP chro- matin, to probe a ... See full document
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Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Replication and Transcription Factor Activates the K9 (vIRF) Gene through Two Distinct cis Elements by a Non-DNA-Binding Mechanism
... Kaposi’s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8), is found in Kaposi’s sarcoma ...Kaposi’s sarcoma (7, ...gamma interferon or other cytokines ... See full document
11
Inhibition of Interferon Signaling by the Kaposi's Sarcoma-Associated Herpesvirus Full-Length Viral Interferon Regulatory Factor 2 Protein
... reporter gene studies, vIRF-1 inhibited IFN signaling from IFN- ␣ /  - and IFN- ␥ -responsive reporter genes, although not by a mechanism that involved DNA binding (13, 15, ...their binding ... See full document
6
Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 K-bZIP Modulates Latency-Associated Nuclear Protein-Mediated Suppression of Lytic Origin-Dependent DNA Synthesis
... that K-bZIP was not absolutely necessary for virus growth and that K-Rta was able to compensate for the lack of K-bZIP expres- ...of K-Rta was unchanged; however, a disruption of ... See full document
10
Modulation of Human Herpesvirus 8/Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Activator Transactivation by Interferon Regulatory Factor 7
... lytic gene expression in latently infected PEL cells (10, 27, 28, ...the herpesvirus family mem- ...of herpesvirus saimiri, and gene 4 of varicella-zoster ...RNA 3 ⬘ processing, ... See full document
12
Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma Associated Herpesvirus Induced Lymphangiogenesis
... Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiologic agent for Kaposi’s sarcoma (KS), which is one of the most common HIV-associated ...viral interferon regulatory ... See full document
12
Transcriptional Regulation of the Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor Gene
... Kaposi’s sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8, open reading frame (ORF) K9 encodes a viral interferon regulatory factor (vIRF) that functions as a ... See full document
12
Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor
... the interferon-stimulated response element (ISRE) pro- moter by IRF-1, as well as activation of the IFN reporter promoter by either IRF-3 or IRF-1, but not by IRF-7 ...of interferon-stimulated ... See full document
11
Mechanisms Governing Expression of the v-FLIP Gene of Kaposi's Sarcoma-Associated Herpesvirus
... Does this splicing event occur in bona fide KSHV infection, or is it limited to cells transiently transfected with recombinant plasmids? To answer this question, we examined several PEL cell lines that harbor latent KSHV ... See full document
7
Role of Notch Signal Transduction in Kaposi's Sarcoma-Associated Herpesvirus Gene Expression
... their responsive elements through interaction with the transcription factor RBP-J (29, 37, ... binding sites are present in a number of EBNA2- and RTA-regulated viral ...by binding ... See full document
13
Activation of CD21 and CD23 Gene Expression by Kaposi's Sarcoma-Associated Herpesvirus RTA
... the expression of Ig ...EBNA2-responsive elements by interaction with RBP-J transcription factor, indicating that EBNA2 is a func- tional homolog of the activated Notch protein ...CD21 ... See full document
13
Chromatin Immunoprecipitation and Microarray Analysis Suggest Functional Cooperation between Kaposi's Sarcoma-Associated Herpesvirus ORF57 and K-bZIP
... to K-bZIP and to Rta ...as K-bZIP (Fig. 3 and 4) (45). K-bZIP binds Rta and inhibits its transcriptional activation func- tion, but in some cases, it coactivates ... See full document
12
Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells.
... KS-associated herpesvirus (KSHV) genes in the tumor cell itself, from the earliest stages of tumor formation ...KSHV gene expression with endothelium-derived KS tumor cells in a spectrum of ... See full document
5
HIV/AIDS: epidemiology, pathophysiology, and treatment of Kaposi sarcoma-associated herpesvirus disease: Kaposi sarcoma, primary effusion lymphoma, and multicentric Castleman disease.
... The clinical context of KS (i.e., HIV status, transplant status, and extent and site of disease) is crucial for the selection of appropriate treatment. Patients with limited local disease may benefit from a variety of ... See full document
7
Overexpression of the Kaposi's Sarcoma-Associated Herpesvirus Transactivator K-Rta Can Complement a K-bZIP Deletion BACmid and Yields an Enhanced Growth Phenotype
... of K-Rta protein present in each cell ...The K-Rta protein levels were similar in each cell line, demonstrating that Ad50 efficiently infected both cell ...a K-Rta expression plasmid (pTarget ... See full document
14
Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor Confers Resistance to the Antiproliferative Effect of Interferon-α
... Materials and Methods: The human B lymphocyte cell line Daudi, which is sensitive to the antiproliferative effects of IFN-a, was stably transfected to express vIRF, and the proliferative[r] ... See full document
11
Modulation of Host Gene Expression by the K15 Protein of Kaposi's Sarcoma-Associated Herpesvirus
... which expression of the endogenous 45-kDa K15 protein could be observed in the context of the entire viral genome, we decided to study its function in epithelial ... See full document
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