[PDF] Top 20 Association of the Human Papillomavirus Type 11 E1 Protein with Histone H1
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Association of the Human Papillomavirus Type 11 E1 Protein with Histone H1
... The E1 and E2 proteins are the only virus-encoded factors required for human papillomavirus (HPV) DNA ...The E1 protein is a DNA helicase responsible for initiation of DNA replication ... See full document
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The Carboxyl-Terminal Region of the Human Papillomavirus Type 16 E1 Protein Determines E2 Protein Specificity during DNA Replication
... hybrid E1 protein genes were constructed (Fig. 2). Each hybrid E1 gene encodes a protein identical in length (649 amino acids) to that encoded by the wild-type HPV-11 or HPV-16 ... See full document
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Dynamic Localization of the Human Papillomavirus Type 11 Origin Binding Protein E2 through Mitosis While in Association with the Spindle Apparatus
... E2 protein contribute to carcinogenesis? It is our opinion that, initially, both the E1 and E2 proteins might be expressed from intact copies of integrated HPV ...E2 protein would be able to bind to ... See full document
9
Mitogen-Activated Protein Kinases Activate the Nuclear Localization Sequence of Human Papillomavirus Type 11 E1 DNA Helicase To Promote Efficient Nuclear Import
... HPV-11 E1 NLS by ...HPV-11 E1 ATPase/DNA helicase is a substrate of MAPKs and that phosphorylation of both S89 and S93, in addition to the NLS, is crucial for efficient E1 nuclear ... See full document
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Human Papillomavirus Type 16 E1∧E4 Contributes to Multiple Facets of the Papillomavirus Life Cycle
... which E1 ∧ E4 contributes to plasmid DNA replication in the context of the nonproductive infective ...First, E1 ∧ E4 can stimulate the activity of the papillomaviral early protein ...to ... See full document
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The Hinge of the Human Papillomavirus Type 11 E2 Protein Contains Major Determinants for Nuclear Localization and Nuclear Matrix Association
... HPV-11 E1 and E2 proteins ...E2 protein binds to RPA via the 70-kDa subunit and enhances the single-stranded DNA bind- ing activities of both (Lee et ...data). E1 also binds to the same RPA ... See full document
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CCAAT Displacement Protein Binds to and Negatively Regulates Human Papillomavirus Type 6 E6, E7, and E1 Promoters
... the human tryptophan hydroxylase (hTPH) regula- tory region, there are two footprints, FP-I and ...activator protein which binds to an overlapping site (7, 35, 36, 48, 51, ...binding protein, may ... See full document
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Mutational analysis of the human papillomavirus type 16 E1--E4 protein shows that the C terminus is dispensable for keratin cytoskeleton association but is involved in inducing disruption of the keratin filaments.
... E4 protein does not dis- rupt the keratin filaments (39, 44), while mucosal E4 proteins do (12, 38, 39), and our studies indicate that the HPV-16 E4 C terminus is important for keratin disruption ...HPV-16 ... See full document
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The E1∧E4 Protein of Human Papillomavirus Type 16 Associates with a Putative RNA Helicase through Sequences in Its C Terminus
... of E1 ∧ E4 and E4-DBP proteins for in vitro binding assays and antibody ...Maltose-binding protein (MBP), glutathione S-transferase (GST), and His-tagged fusion proteins were expressed from recombinant pGEX ... See full document
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Structural Analysis Reveals an Amyloid Form of the Human Papillomavirus Type 16 E1∧E4 Protein and Provides a Molecular Basis for Its Accumulation
... its association with  -strand-based fibrils, with both 16E4 ⌬ 2-5 (blue) and amyloid-  (1-42) (turquoise) but not with 16E1 ∧ E4 (black) or BSA (yellow), NIAD-4 alone is also shown ...its association with ... See full document
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Phosphorylation of the Human Papillomavirus Type 16 E1^E4 Protein at T57 by ERK Triggers a Structural Change That Enhances Keratin Binding and Protein Stability
... and protein G-Sepharose beads ...the association in the cell, coimmunoprecipitation was carried out using cells expressing WT 16E1 E4, 16E1 E4 T57A, or T57D ...different E1 E4 forms present in the ... See full document
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The E1^E4 Protein of Human Papillomavirus Interacts with the Serine-Arginine-Specific Protein Kinase SRPK1
... virus type 1 encodes a pro- tein ICP27 which associates with SRPK1, relocating it to the nucleus, resulting in hypophosphorylation of SR proteins and a consequent impairment in spliceosome assembly ...virus ... See full document
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Role of the ATP-Binding Domain of the Human Papillomavirus Type 11 E1 Helicase in E2-Dependent Binding to the Origin
... of E1 by E2 to the HPV origin is an essential step in the initiation of viral DNA ...of E1 (amino acids 353 to 649) is sufficient for interaction with the TAD of E2 (amino acids 1 to 209) and for ... See full document
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Identification of a G2 Arrest Domain in the E1∧E4 Protein of Human Papillomavirus Type 16
... that E1 ∧ E4 cooperates with E2 or with other viral gene ...viral E1 and E2 pro- teins, which are involved in viral DNA replication, cooperate in the assembly of the initiation complex at the viral origin ... See full document
13
Human TATA Binding Protein Inhibits Human Papillomavirus Type 11 DNA Replication by Antagonizing E1-E2 Protein Complex Formation on the Viral Origin of Replication
... of papillomavirus transcription and replication based upon interactions between host cell transcription factors and the viral E1 and E2 proteins ...of E1 yet acts competitively with E2 yields insight ... See full document
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Identification of Domains of the Human Papillomavirus Type 11 E1 Helicase Involved in Oligomerization and Binding to the Viral Origin
... the E1 oligomerization domain in addition to sequences required for contacting ...truncated E1 (191 to 649) is able to support HPV DNA replication in a human cell-free system, albeit with re- duced ... See full document
13
Yin Yang 1 Negatively Regulates the Differentiation-Specific E1 Promoter of Human Papillomavirus Type 6
... the human gamma interferon promoter (72), and signal transducer and activator of tran- scription 5 in the beta-casein promoter (18, ...the histone acetylase CREB binding protein, a coactivator of ... See full document
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The E1 Protein of Human Papillomavirus Type 16 Is Dispensable for Maintenance Replication of the Viral Genome
... PV E1 protein forms double hexamers at the replication origin in the LCR with the help of E2 (2, 11, 43) and unwinds DNA through helicase activity ahead of replication forks powered by the hydrolysis ... See full document
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Characterization of human papillomavirus type 11 E1 and E2 proteins expressed in insect cells.
... To confirm that the HPV-11 proteins expressed in insect cells are biologically active, we assayed protein from crude nuclear extracts for a number of the activities which the HPV-11 prot[r] ... See full document
9
Replication of human papillomavirus (HPV) DNAs supported by the HPV type 18 E1 and E2 proteins.
... To rigorously investigate the efficiency of replication of the various ori plasmids, 0.5 ,ug of pUCLCR-18 and equimolar amounts of the various ori plasmids were cotransfected into C-33A [r] ... See full document
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