[PDF] Top 20 Bacterial outer membrane vesicles and vaccine applications
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Bacterial outer membrane vesicles and vaccine applications
... the vaccine strain ...of vaccine efficacy in children and infants are over 70%, although the number of doses required may differ between each vaccine in order to keep protective immunity for a longer ... See full document
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Genetic Similarity of Gonococcal Homologs to Meningococcal Outer Membrane Proteins of Serogroup B Vaccine
... Bacterial strain collection. This study included 970 N. gonorrhoeae isolates from 27 sites partici- pating in GISP, a national sentinel surveillance system (https://www.cdc.gov/std/gisp/default.htm), ob- tained ... See full document
14
Outer Membrane Vesicles Induce Immune Responses to Virulence Proteins and Protect against Colonization by Enterotoxigenic Escherichia coli
... While our studies suggest that ETEC-derived OMV could induce responses to multiple antigens, including known and putative virulence proteins, significant efforts will be required to explore their true utility in ... See full document
6
Development of a thermostable spray dried outer membrane vesicle pertussis vaccine for pulmonary immunization
... DPPC-cholesterol vesicles during freeze ...phospholipid membrane by direct interaction with it, possibly due to hydrogen ...the vaccine (as observed by DLS and TEM), further no aggregation occurred ... See full document
12
Immunogenicity of Nontypeable Haemophilus influenzae Outer Membrane Vesicles and Protective Ability in the Chinchilla Model of Otitis Media
... for bacterial variants downregulated in HMW1/HMW2 and Hia protein expression (14, ...NTHi outer membrane vesicles (OMVs) as immuno- gens and as supplemental vaccine ...are ... See full document
12
A Burkholderia pseudomallei Outer Membrane Vesicle Vaccine Provides Protection against Lethal Sepsis
... effective vaccine. Gram-negative bacteria, including B. pseudomallei, secrete outer membrane vesicles (OMVs) which are enriched with multiple protein, lipid, and polysaccharide ...promoted ... See full document
8
Construction of a bacterial surface display system based on outer membrane protein F
... Background: Bacterial surface display systems were developed to surface expose heterologous proteins or peptides for different applications, such as peptide libraries screening and live bacterial ... See full document
13
Helicobacter pylori outer membrane vesicles involvement in the infection development and Helicobacter pylori-related diseases
... of bacterial vesiculation Outer membrane vesicles are defined as 20–300 nm blebs, which are naturally secreted by Gram-negative bacteria mainly during their logarithmic phase of growth ... See full document
11
A Bilayer Couple Model of Bacterial Outer Membrane Vesicle Biogenesis
... produce outer membrane vesicles (OMVs) that arise through bulging and pinching off of the outer ...the outer leaflet of the outer ...induced membrane curvature, resulting ... See full document
7
Surface Exposure and Packing of Lipoproteins into Outer Membrane Vesicles Are Coupled Processes in Bacteroides
... host cells (16). Most studies focus primarily on two predominant species in the human gut, Bacteroides thetaiotaomicron and Bacteroides fragilis. These species produce large amounts of uniformly sized OMVs that have a ... See full document
14
Neisseria meningitidis Native Outer Membrane Vesicles Containing Different Lipopolysaccharide Glycoforms as Adjuvants for Meningococcal and Nonmeningococcal Antigens
... LPS is a potent inducer of the innate immune system through activation of the TLR-4/MD2 complex, and as such, it is a prom- ising adjuvant candidate for many vaccines if it can be rendered less toxic (41). The recent ... See full document
9
Protection against neonatal enteric colibacillosis employing E Coli derived outer membrane vesicles in formulation and without vitamin D3
... The source of animals and experiment procedures were approved and monitored by animal care center, Faculty of Veterinary Medicine, University of Tehran. The study population consists of 30 female mice (BALB/c back- ... See full document
8
Evaluation of antibody responses to outer membrane vesicles (OMVs) and killed whole cell of Vibrio cholerae O1 El Tor in immunized mice
... koral vaccine consists of a mixture of Ogawa and Inaba serotypes, El Tor and classical biotypes con- taining cholera toxin B–subunit ...Shanchol vaccine lacks CTB but contains a ... See full document
8
Outer Membrane Protein Complex of Meningococcus Enhances the Antipolysaccharide Antibody Response to Pneumococcal Polysaccharide–CRM197 Conjugate Vaccine
... These bacterial PS are T cell-independent (TI) type 2 antigens, induce predominantly IgM antibody without immune memory, and are poor immunogens in infants under 24 months of age (6, 8, ...Most bacterial ... See full document
6
Comparative study of pathogenic and non pathogenic Escherichia coli outer membrane vesicles and prediction of host interactions with TLR signaling pathways
... pathogenic bacterial strain lead to the development of inflammation, by inducing the expression of pro-inflam- matory cytokines through the involvement of various TLRs by PAMPs on the luminal surface, so that they ... See full document
7
The lytic mechanism of Escherichia coli α hemolysin associated to outer membrane vesicles
... in vesicles suggests that OMVs may have a key role in bacterial pathogenesis by mediating transmission of active virulence factors and other bacterial envelop- ment component to host ...to ... See full document
9
Antibiotic treatment modulates protein components of cytotoxic outer membrane vesicles of multidrug-resistant clinical strain, Acinetobacter baumannii DU202
... treatment. Bacterial OMVs play important role as potent bacterial virulence factors [17] and a high incidence of resistance to imipenem has been reported for clinical ... See full document
11
Construction of an Expression Plasmid (Vector) Encoding Brucella melitensis Outer Membrane Protein, a Candidate for DNA Vaccine
... Background: DNA vaccination with plasmid encoding bacterial, viral, and parasitic immunogens has been shown to be an attractive method to induce efficient immune responses. Bacteria of the genus Brucella are ... See full document
5
Characterization and Vaccine Potential of Membrane Vesicles Produced by Francisella noatunensis subsp. orientalis in an Adult Zebrafish Model
... of membrane vesicles (MVs) ...the vesicles contain a variety of bacterial components, including periplasmic and outer membrane (OM) proteins as well as lipopolysaccharides (LPS), ... See full document
19
Studies on the synergistic protective activity of cancer antigens associated to engineered bacterial Outer Membrane Vesicles
... Very recently, the first-in-human testing of such an approach has been conducted by Sahin and co-workers 103 . Non-synonymous mutations expressed by 13 patients with stage III and IV melanoma were identified by ... See full document
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