[PDF] Top 20 BAI1 regulates spatial learning and synaptic plasticity in the hippocampus

... for BAI1 as a negative regulator of MDM2-medi- ated PSD-95 ...ubiquitin, BAI1, and MDM2. Cotransfection with BAI1 induced a striking stabilization of PSD-95 levels, accompanied by a substantial ... See full document

... for learning and memory [4-8], the isoform-specific roles of PI3Ks are still largely ...reversal learning in the Morris water maze (MWM) task ...studied hippocampus-dependent learning and ... See full document

... on synaptic plasticity in hippocampal brain slices of ...long-term synaptic plasticity of region I of ...in hippocampus. In view of the important role of NO in synaptic ... See full document

... silent synaptic terminals (ie increase in N), then little or no change in Qav is ...of synaptic modulation, and strongly supports a postsynaptic site for LTP expression at MPP synapses onto dentate granule ... See full document

... eye movement (NREM) and rapid eye movement (REM) sleep (Stickgold, 1998). In humans, NREM sleep can further be dissected into 4 stages. Rechtshaffen and Kales developed the standard scoring guidelines to determine sleep ... See full document

... In freely m oving anim als, sensory stim ulation and m otor behaviour were found to be accom panied by increased release o f ACh in hippocam pus (M arrosu et al., 1995). For exam ple, novelty exposure induced higher A Ch ... See full document

... homozygous (Mapt −/− ) mice. (a, b) In both adult (a) and aged (b) groups, LFS (900 pulses, 1 Hz) effectively reduced the fEPSP amplitude (slope) for at least 60 min in wild-type mice, but not in tau-knockout ... See full document

... segment of the axon which is first depolarized to threshold, the action potential being propagated back into the soma and forward down the axon. This positive inward current in the soma is associated with outward current ... See full document

... the hippocampus, non-specific blockers of EAATs have prevented damage to neurones subjected to hypoxia and ischaemic conditions, thus identifying the major role played by EAATs during the induction of ... See full document

... Enhanced hippocampal LTP was also reported in very young P301L mice (5–7 weeks of age), but only in the dentate gyrus [17]. This group also showed that young P301L mice had improved performance in the novel ob- ject ... See full document

... on spatial learning and memory and synaptic plasticity in the hippocampus of young rats, and tried to interpret the underlying ...long-term synaptic plasticity broke the ... See full document

... This study found that a theta burst stimulation protocol to the temporoammonic pathway or to the RE-CA1 synapse induces LTP in the synapse that receives the tetanic stimulation in urethane-anaesthetized mice. These ... See full document

... The examples discussed above underscore many roles played by MMP-3 in the developing and adult CNS. Although, over the years, more attention has been directed to the function of MMP-3 in pathophysiological processes, ... See full document

... of learning would state that learning modulates (changes) the input output, or stimulus action relationship of an ...the hippocampus show that these neurons change their "place field" ... See full document

... underlying synaptic mecha- nisms as ...decreased synaptic excitation and intact synaptic inhibition, meanwhile Schaffer collateral-CA1 synapses of L100P mice display impaired synaptic ...mice ... See full document

... during learning, such that memory allocation is not random but rather is regulated by precise mechanisms which define where and how information is stored within the neural network ...as hippocampus, cortex ... See full document

... normal learning and memory, which makes it more dif- ficult to draw conclusions about the role of LTP in ...and hippocampus-dependent spatial memory ...of synaptic plasticity does play ... See full document

... and spatial learning, ...in hippocampus and upregulated GDNF, NCAM, CREB, PSD95, and GAP43 compared to vehicle and other Dex ...enhances spatial learning and memory in rat pups, ... See full document

... predator-induced plasticity The patterns of expression in the gene network ...phenotypic plasticity can be charac- terised as a smooth reaction norm, rather than a discrete threshold ... See full document

... the ratio of p-CREB to CREB were positively correlated with the dose of VTF. The downregulation of CREB phosphorylation is therefore closely related to the de- cline of learning and memory ability in patients with ... See full document