[PDF] Top 20 Bench to bedside review: Sepsis is a disease of the microcirculation

... These findings led us to propose that the addition of systemic NO to adequately volume resuscitated patients with septic shock results in an improvement of microcirculatory perfusion. In a small observational study in ... See full document

... the disease condition and require further pathways and functional enrichment analyses to understand the biological mecha- ...in disease as well as yielding candidate pathways for therapeutic inter ...in ... See full document

... In sepsis, infl ammation and thrombosis are both the cause and the result of interactions between circulating (for example, leukocytes and platelets), endothelial and smooth muscle ...of sepsis through ... See full document

... In sepsis, nitric oxide synthesis is dysregulated with exaggerated production leading to cardiovascular dysfunction, bioenergetic failure and cellular toxicity whilst at the same time impaired microvascular ... See full document

... meningococcal disease, which is in contrast with the association of high TNF levels and the adverse outcome shown by other studies ...meningococcal sepsis is unclear ...meningococcal sepsis is ... See full document

... Gram-negative disease, with no effect in patients with Gram-positive infection ...Gram-positive disease have potentially been harmed in trials of IL-1 receptor antagonists [41] and anti-LPS (HA-1A) ... See full document

... the disease? (iii) How does the anti-oxidant work - by scavenging reactive species, increasing endogenous defence or by repairing the damage? (iv) Can the anti-oxidant-derived products cause damage? (v) Does the ... See full document

... The microcirculation is a complex and integrated system that supplies and distributes oxygen throughout the ...the microcirculation oxygen diffuses from the RBC into neighboring tissues, where it is ... See full document

... Complement-mediated opsonic activity may appear in the cerebrospinal fl uid of patients who recover com- pletely from bacterial meningitis and may infl uence the outcome of the disease [46]. In a rat model of ... See full document

... 18 hours), the rate of cytochrome a,a 3 reduction during tourniquet ischemia was markedly slowed, a finding that was felt to be consistent with the presence of either a defect in the ability of the enzyme to accept ... See full document

... the balance between the carbon dioxide produced and that eliminated. Hypocapnia remains a common – and generally underappreciated – component of many disease states, including early asthma, high-altitude pulmonary ... See full document

... kidney disease, arteriosclerosis, inflammatory bowel disease, neurodegener- ative disorders (especially Alzheimer disease), and wound- healing disorders ... See full document

... Recent studies have shown that polymorphic alleles may be differentially expressed within an individual and that this may contribute to phenotypic variation [90-94]. Classically, allele- specific differences in ... See full document

... of sepsis, the response to current medical treatment, and the genetic predisposition to infection in each individual ...of sepsis and organ dysfunction during severe ...this review, we focus on the ... See full document

... of disease: feeding MitoQ to rats decreased heart dysfunction, cell death, and mitochondrial damage upon subsequent ischemia-reperfusion in isolated hearts [42], protected endothelial cell function and damage to ... See full document

... lung disease; CADM: clinically amyopathic dermatomyositis; TIF1: transcription intermediary factors-1; TRIM: tripartite motif-containing proteins; NXP-2: nuclear matrix protein 2; PML: pro-myeloc- itic leukaemia ... See full document

... with sepsis have implications for heart-lung interactions ...in sepsis, inspiratory effort must be greater for the same tidal volume and consequently pleural pressure swings for each breath must ... See full document

... AKI and critical illness are characterized by a catabolic state, insulin resistance, and altered carbohydrate and glucose metabolism. These changes are provoked by counter- regulatory hormones, acidosis, and cytokines. ... See full document

... Permissive hypercapnia is a central component of current protective lung ventilatory strategies in the clinical context. Furthermore, induced hypercapnic acidosis appears to demonstrate considerable protective effects in ... See full document

... HBO has been studied and used in a large variety of infections for over 40 years. Early demonstrations of its beneficial effects in clostridial myonecrosis (gas gangrene) [73] and in chronic refractory osteomyelitis [74] ... See full document