[PDF] Top 20 Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus
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Blockade of Interferon Induction and Action by the E3L Double-Stranded RNA Binding Proteins of Vaccinia Virus
... The E3L gene was inserted into the parental VV⌬E3L virus of strain WR by recombination of pMP E3L plasmid into the E3L locus of VV⌬E3L, following a procedure previously described ... See full document
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Mouse Hepatitis Virus Does Not Induce Beta Interferon Synthesis and Does Not Inhibit Its Induction by Double-Stranded RNA
... IFN induction requires the transmembrane (M) protein, and mutation of a single amino acid abrogates its interferogenic ability ...(25). Induction is also dependent upon the glycosylation status of the M ... See full document
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Vaccinia Virus Subverts a Mitochondrial Antiviral Signaling Protein-Dependent Innate Immune Response in Keratinocytes through Its Double-Stranded RNA Binding Protein, E3
... encoding proteins that interdict the extracellular and intracellular com- ponents of those pathways ...cinia virus dsRNA-binding protein E3, which can inhibit the PKR and NF- B pathways (10, 14, ... See full document
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Suppression of Proinflammatory Signal Transduction and Gene Expression by the Dual Nucleic Acid Binding Domains of the Vaccinia Virus E3L Proteins
... the interferon (IFN) response, play a key role in limiting the spread of virus soon after infection and in inducing an adaptive immune response (20, ...55). Vaccinia virus (VV), a type member ... See full document
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Double-Stranded RNA Binding of Influenza B Virus Nonstructural NS1 Protein Inhibits Protein Kinase R but Is Not Essential To Antagonize Production of Alpha/Beta Interferon
... influenza virus (39). It is also possible that the dsRNA-binding activity of NS1 contributes to another step during influenza B virus replication that is not known at this ...NS1 virus ... See full document
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West Nile Virus-Induced Interferon Production Is Mediated by the Double-Stranded RNA-Dependent Protein Kinase PKR
... examining virus- dependent induction of gene products (including ISG56 and ISG54) which are primarily dependent on IRF3 transcriptional activation (18, ...factor binding sites, including those for ... See full document
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Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene.
... The vaccinia virus (VV) E3L gene, which encodes a potent inhibitor of the interferon (IFN)-induced, double-stranded RNA (dsRNA)-dependent protein kinase, PKR, is thought ... See full document
7
Double-Stranded RNA Binding by a Heterodimeric Complex of Murine Cytomegalovirus m142 and m143 Proteins
... by double-stranded (ds) ...dsRNA-binding proteins that prevent the activation of these pathways and thereby enable continued protein synthesis and viral ...two proteins interact in ... See full document
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Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: Varying the number of double-stranded RNA binding domains and lineage-specific duplications
... the Vaccinia virus proteins E3L and K3L, orthologs of which are found in many ...poxviruses. E3L and K3L are important virulence factors and are involved in determining host range ... See full document
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Noncytopathic Bovine Viral Diarrhea Virus Inhibits Double-Stranded RNA-Induced Apoptosis and Interferon Synthesis
... diarrhea virus (BVDV), a pestivirus of the Flaviviridae family, is an economically important cattle pathogen with a worldwide ...the induction of apoptosis and the expression of interferon ␣ /  by ... See full document
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Possible Involvement of the Double-Stranded RNA-Binding Core Protein ςA in the Resistance of Avian Reovirus to Interferon
... a double protein capsid shell of 70 to 80 nm in diameter ...alpha/beta interferon (rcIFN) (50) prompted us to investigate its effect on the replication of avian reovirus S1133 in primary cultures of chicken ... See full document
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Dissection of Double-Stranded RNA Binding Protein B2 from Betanodavirus
... dsRNA binding and ...dsRNA binding can only be predicted, but it is of obvious significance that a num- ber of other viral dsRNA binding proteins, including human immunodeficiency virus ... See full document
11
Double-Stranded RNA Binding by Human Cytomegalovirus pTRS1
... of vaccinia virus (VV) that has a deletion of the double-stranded RNA binding protein gene E3L (VV ⌬ ...Like E3L, these HCMV genes block the activation of key ... See full document
9
Complementation of Vaccinia Virus Lacking the Double-Stranded RNA-Binding Protein Gene E3L by Human Cytomegalovirus
... the E3L gene of vaccinia virus that counteract these host antiviral ...pathways. Vaccinia virus from which the E3L gene has been deleted (VV ⌬ E3L) is highly sensitive to ... See full document
7
Contribution of Double-Stranded RNA and CPSF30 Binding Domains of Influenza Virus NS1 to the Inhibition of Type I Interferon Production and Activation of Human Dendritic Cells
... CPSF30 binding domain of the A/Texas/36/91 NS1 is impor- tant for inhibition of type I IFN production and activation of human ...CPSF30 binding domain of Tx NS1 in the activa- tion of DCs and type I IFN ... See full document
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Mechanism of interferon action: functionally distinct RNA-binding and catalytic domains in the interferon-inducible, double-stranded RNA-specific adenosine deaminase.
... negative-stranded RNA viruses (6) as exemplified by modification of measles virus RNA (7), but also in other virus types as exemplified by modification of retroviral RNA ... See full document
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Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants
... dsRNA binding studies, usually carried out with poly(I·C), as well as by activation of dsRNA pathways in cells infected with mutant ...(a virus gen- erated as a revertant of a D10 mutant and used as the ... See full document
16
Double-Stranded RNA Binding May Be a General Plant RNA Viral Strategy To Suppress RNA Silencing
... long-dsRNA- binding activity should be detectable in TCV viral extracts and in an extract that is prepared from leaves, in which CP is expressed ...viral proteins was studied in gel mobility shift ... See full document
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Expression of yeast L-A double-stranded RNA virus proteins produces derepressed replication: a ski- phenocopy.
... 155 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The plus strand of the L-A double-stranded RNA virus of Saccharomyces cerevisiae has two large open reading frames, [r] ... See full document
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Double-Stranded RNA Adenosine Deaminases Enhance Expression of Human Immunodeficiency Virus Type 1 Proteins
... on double-stranded RNA) are RNA editing enzymes that catalyze a change from adenosine to inosine, which is then recognized as guanosine by translational ...immunodeficiency virus type 1 ... See full document
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