[PDF] Top 20 The BRAF V600E mutation: what is it really orchestrating in thyroid cancer?
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The BRAF V600E mutation: what is it really orchestrating in thyroid cancer?
... laminins cross-linking, mechanical events such as visco- elasticity or stiffness, which have been implicated in tumorigenesis and tumor invasion) of the ECM proteins. These modifications then significantly alter tumor ... See full document
6
Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation
... the BRAF V600E mutation are associated with aggressive clinicopathologic features in thyroid ...in thyroid cancer patients with a high prevalence of BRAF ...F V600E ... See full document
10
Original Article Overexpression of trophoblast cell surface antigen 2 is associated with BRAF V600E mutation and aggressive behavior in papillary thyroid cancer
... RAS mutation respond to ERK feedback via RAF dimers resulting in lower ...without BRAF mutation, we found out that trop- 2 was also associated with LNM but not ETE, which means that trop-2 could be ... See full document
10
<em>DUSP4</em>/MKP2 overexpression is associated with BRAF<sup>V600E</sup> mutation and aggressive behavior of papillary thyroid cancer
... Fisher’s exact tests. Human-derived thyroid cell lines were also used to verify our findings. DUSP4 was significantly overexpressed in PTC tissues compared with the adjacent normal tissues (P,0.001). High DUSP4 ... See full document
9
Original Article Clinicopathological significance of BRAF V600E mutation in Uyghur Chinese patients with papillary thyroid carcinoma
... Thyroid cancer ranks first in the head and neck neoplasms, and is the most common malignant tumor of the endocrine system ...all thyroid cancer [2]. The incidence of thyroid ... See full document
8
Original Article TERT and BRAF promote proliferation of thyroid cancer cells
... promoter mutation and thyroid cancer, the roles of BRAF V600E mutation with TERT promoter mutation in thyroid cancer have grad- ually attracted the attention ... See full document
8
VE1 immunohistochemistry predicts BRAF V600E mutation status and clinical outcome in colorectal cancer
... and thyroid cancers (n = ...and V600E mutation was ...for V600E and homogeneously expressed suggesting staining can be analysed on resection specimens, preoperative biopsies, metastatic ... See full document
11
Classical V600E and other non hotspot BRAF mutations in adult differentiated thyroid cancer
... inactive BRAF protein and constitutively switching to active ...latter mutation was also detected in another patient from our ...This mutation was previously described in a pilo- cytic astrocytoma ... See full document
8
BRAF V600E expression found in aggressive papillary thyroid carcinoma (PTC), lymph node metastasis, and extra-thyroid extension
... 7. Xing M, Alzahrani AS, Carson KA, Shong YK, Kim TY, Viola D, Elisei R, Bendlova B, Yip L, Mian C, Vianello F, Tuttle RM, Robenshtok E, Fagin JA, Puxeddu E, Fugazzola L, Czarniecka A, Jarzab B, O'Neill CJ, Sywak MS, Lam ... See full document
5
Long-term vemurafenib treatment drives inhibitor resistance through a spontaneous KRAS G12D mutation in a BRAF V600E papillary thyroid carcinoma model
... The BRAF V600E mutation is commonly observed in papillary thyroid cancer (PTC) and predominantly activates the MAPK ...of BRAF V600E predicts increasing risk of recurrence ... See full document
17
Diagnostic value of <em>BRAF<sup>V600E</sup></em>-mutation analysis in fine-needle aspiration of thyroid nodules: a meta-analysis
... ([thyroid cancer] or [thyroid neoplasm] or [thy- roid tumor]), (BRAF), and ([FNA] or [fine needle ...for BRAF V600E -mutation analysis was obtained ... See full document
15
Original Article BRAF mutation in breast cancer by BRAF V600E mutation-specific antibody
... regarding thyroid cancer tis- sues, the expression was reported to be diffuse and homogenous in positive cases in general [16, 22], and the result of our study with breast cancer also showed diffuse ... See full document
12
Original Article Association of BRAF V600E mutation with clinicopathological features of papillary thyroid carcinoma: a study on a Chinese population
... [8] Xing M, Westra WH, Tufano RP, Cohen Y, Rosenbaum E, Rhoden KJ, Carson KA, Vasko V, Larin A, Tallini G, Tolaney S, Holt EH, Hui P, Um- bricht CB, Basaria S, Ewertz M, Tufaro AP, Cali- fano JA, Ringel MD, Zeiger MA, ... See full document
7
Sensitive detection of BRAF V600E mutation by Amplification Refractory Mutation System (ARMS)-PCR
... BRAF V600E mutation testing has demonstrated util- ity in helping select CRC patients who are considering monoclonal antibody therapy as wild-type BRAF is required for response to anti-EGFR ... See full document
6
Dual EGFR and BRAF blockade overcomes resistance to vemurafenib in BRAF mutated thyroid carcinoma cells
... human cancer cells ...and BRAF alternative splicing or other alterations, both upstream and downstream to BRAF, leading to reactiva- tion of ERK pathway, provided the rational for combina- tion ... See full document
9
Original Article Association between BRAF and RAS mutations, and RET rearrangements and the clinical features of papillary thyroid cancer
... lary thyroid cancer (PTC) in the South central region of ...for BRAF mutation, RAS mutation, and RET rear- rangement ...for BRAF and RAS mutation status, RET ... See full document
8
Original Article Langerhans cell histiocytosis in Chinese adults: absence of BRAF mutations and increased FOXP3 regulatory T cells
... human cancer, and plays an impor- tant role in cancer induction, maintenance and progression ...[13]. BRAF gene mutations occur in a variety of tumors and cancer cell lines, especially in ... See full document
8
Original Article Association between BRAF V600E mutation and regional lymph node metastasis in papillary thyroid carcinoma
... Five μm-thick FFPE sections were mounted onto microscopic slides and deparaffinized using xylene and ethanol. For each tissue block one slide was preserved for Hematoxylin and Eosin (H&E) staining. Experienced ... See full document
7
Original Article Immunohistochemistry is highly sensitive and specific for detecting the BRAF V600E mutation in papillary thyroid carcinoma
... [2] Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, ... See full document
7
Expression of braf mutation in thyroid neoplasms
... on thyroid specimens reported at PSGIMS&R from January 2006 to September 2009 revealed a 31% incidence of papillary carcinoma and ...expressing BRAF V600E mutation. We also infer that ... See full document
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