[PDF] Top 20 BST-2 Diminishes HIV-1 Infectivity
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BST-2 Diminishes HIV-1 Infectivity
... BST-2 diminishes HIV-1 infectivity in SupT1 ...whether BST-2 exerts an adverse effect on HIV-1 infec- tivity in its natural target, CD4 ⫹ T ...human ... See full document
8
Loss of Niemann Pick type C proteins 1 and 2 greatly enhances HIV infectivity and is associated with accumulation of HIV Gag and cholesterol in late endosomes/lysosomes
... Ca 2+ for recruitment into lipid rafts in a fibroblast cell line (L1) derived from an NPCD patient, Domon et ...[31,32]. HIV-1 budding and assembly occurs primarily at lipid rafts and Gag has been ... See full document
10
Inhibitory Effects of HIV-2 Vpx on Replication of HIV-1
... type 1 (HIV-1) and HIV-2 share a strik- ing genomic resemblance; however, variability in the genetic sequence accounts for the presence of unique accessory genes, such as the viral ... See full document
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Serine-Threonine Ubiquitination Mediates Downregulation of BST-2/Tetherin and Relief of Restricted Virion Release by HIV-1 Vpu
... proviral HIV-1 DNA together with BST-2 expression ...The infectivity of the supernatants was also measured using an infectious center assay ...of BST-2 re- flected the ... See full document
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CA Mutation N57A Has Distinct Strain-Specific HIV-1 Capsid Uncoating and Infectivity Phenotypes
... Virus infectivity was determined by luciferase production (Promega) after 48 h using a 1450 MicroBeta TriLux microplate luminescence counter ...at 2 to 3 days after ... See full document
19
The D-amino acid peptide D3 reduces amyloid fibril boosted HIV-1 infectivity
... promote HIV infection by fa- cilitating viral attachment through neutralization of the electrostatic repulsion between the negatively charged surface of virions and target cells ...of HIV- 1 ... See full document
7
Antagonism of BST-2/Tetherin Is a Conserved Function of the Env Glycoprotein of Primary HIV-2 Isolates
... type 1 (HIV-1) and type 2 (HIV-2) infections are well defined as viral ...that HIV-1 is closely related to simian immunodeficiency virus (SIV) from chimpanzees ... See full document
13
The autophagy protein ATG9A promotes HIV 1 infectivity
... the HIV-1 NL4-3 strain and the three SIV strains (cpz GAB1, mac239 and smm FWR1) were tagged with sequences encod- ing one FLAG and two strep tags (herein referred to as FLAG-Two-Strep or FTS) at the ... See full document
20
Defining the level of human immunodeficiency virus type 1 (HIV-1) protease activity required for HIV-1 particle maturation and infectivity.
... Effect of mutants on viral infectivity. The effect of altered kinetics of polyprotein processing on viral infectivity was ana- lyzed. Infectious particles were generated by cotransfecting the wild-type and ... See full document
8
Distinct HIV 1 entry phenotypes are associated with transmission, subtype specificity, and resistance to broadly neutralizing antibodies
... Comprehensive infectivity profiling requires the exam- ination of each Env under multiple distinct combina- tions of CD4/CCR5 expression ...into HIV-1 entry phenotypes associated with distinct ... See full document
20
Human Immunodeficiency Virus Type 1 Capsid Mutation N74D Alters Cyclophilin A Dependence and Impairs Macrophage Infection
... N74D HIV-1 and G94D HIV-1 displayed distinct patterns of ...N74D HIV-1 was more impaired in macrophage infection than in HeLa cell infection, the infectivity of G94D ... See full document
7
Upregulation of BST 2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV 1 Infected Cells from NK Cell Responses
... of HIV-1, the small accessory protein Vpu acts as a viral antagonist of BST-2 (3, ...Vpu-mediated BST-2 downregulation requires a physical interaction between the transmembrane ... See full document
18
HIV 1 Vif inhibits G to A hypermutations catalyzed by virus encapsidated APOBEC3G to maintain HIV 1 infectivity
... The FRET-based cytidine deaminase assay was per- formed based on a modified protocol adapted from a previously described method [47]. 293T cells were cotransfected with the indicated HIV-1 expression vector ... See full document
10
Isolation of an Active Lv1 Gene from Cattle Indicates that Tripartite Motif Protein-Mediated Innate Immunity to Retroviral Infection Is Widespread among Mammals
... type 1 (HIV-1) infectivity, and the human and New World monkey TRIM5 ␣ proteins are inactive against HIV-1 but active against divergent murine (N-tropic murine leukemia virus ... See full document
7
The presence of host-derived HLA-DR1 on human immunodeficiency virus type 1 increases viral infectivity.
... type 1 (HIV-1) incorporates several host cell components when budding out of the infected ...by HIV-1 is the HLA-DR determinant of the major histocompatibility complex class II (MHC-II) ... See full document
9
The LEM Domain Proteins Emerin and LAP2α Are Dispensable for Human Immunodeficiency Virus Type 1 and Murine Leukemia Virus Infections
... FIG. 2. HIV-1 and MLV can infect MEFs that are knocked out for either emerin or LAP2 ␣ ...of HIV/VSV-G, HIV/Ampho, or MLV/VSV-G was examined in Emd (emerin) knockout MEFs compared to ... See full document
9
Nef Enhances Human Immunodeficiency Virus Type 1 Infectivity in the Absence of Matrix
... the infectivity of virus produced in T cells independent of the presence or absence of ...truncated HIV-1 Env was provided in trans in the Jurkat Tag cells to permit only a single round of virus ... See full document
6
The cellular and molecular basis of the Nef requirement for HIV-1 infectivity
... Table 1 together with the source) were all tested for possible contamination with mycoplasma and tested ...Table 1, TZM-bl indicator cells were obtained from the NIH AIDS Research and Reference Reagent ... See full document
137
HLA C increases HIV 1 infectivity and is associated with gp120
... viral infectivity was observed using CHO cells transfected with HLA-Cw4, as well as HeLa cells which express constitutively HLA-Cw12 and pseudoviruses originating from 293T cells which express HLA-Cw7 (Table ... See full document
15
BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity
... Program), 2 g/ml rabbit anti-BST-2 Ab (sc-99191; Santa Cruz), or sera from HIV-1-infected individuals (1:1,000 dilution), whereas 1 g/ml of either Alexa Fluor ... See full document
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