[PDF] Top 20 Cd8+ T Cell Effector Function And Transcriptional Regulation During Hiv Pathogenesis
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Cd8+ T Cell Effector Function And Transcriptional Regulation During Hiv Pathogenesis
... by CD8 + T cells (Migueles et ...+ CD8 + cells in CPs compared to ECs. This would suggest CD8 + T cells from the group of CPs studied here should provide superior control over ... See full document
154
Regulation of macrophage subpopulations and their relationship to T cell function in the pathogenesis of asthma.
... of function the D1+ inductive cells are distinct from the D7 effector cells and D1/D7 suppressive ...both effector phagocytes and suppressive. Although effector D7+ macrophages may present ... See full document
214
Type I Interferon Signaling Enhances CD8+ T Cell Effector Function and Differentiation during Murine Gammaherpesvirus 68 Infection
... ⫺/⫺ CD8 ⫹ T cells throughout later time points suggested possible ongoing interference with CD8 ⫹ T cell ...of CD8 ⫹ T cells to persistently high antigen levels, similar ... See full document
10
IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells
... of HIV-specific and CMV-specific T cells in subjects with progressive HIV disease, compared to healthy ...multiple HIV and CMV antigens, we were able to ana- lyze a large proportion of the ... See full document
14
Characterising negative regulation of CD8+ T cell function in tolerance and exhaustion
... shown transcriptional and epigenetic commitment to a tolerant phenotype that is maintained even after withdrawal from antigen ...of function within exhausted CD8 + T cells early during ... See full document
239
Peroxiredoxin II Regulates Effector and Secondary Memory CD8+ T Cell Responses
... redox regulation of CD8 ⫹ T cell activation and differentiation is ...primary effector CD8 ⫹ T cell responses in PrdxII ⫺/⫺ mice was not sustained, immunological ... See full document
13
Transcriptional Control and Population Dynamics of Antiviral CD8+ T Cell Responses
... well-known effector function of “killer” T cells is the destruction of virally infected target ...target cell inducing cell death (Trapani and Smyth, ...programmed cell death of ... See full document
118
Regulation of Cd8 T Cell Dysfunction During a Chronic Viral infection
... the pathogenesis of both infections (220, 221, 227) and LCMV clone 13 can infect APCs such as macrophages and DCs (87, 88), which raises the possibility that antigen-presentation and activation of the ... See full document
167
Distinct roles of CD4+T cell subpopulations in retroviral immunity: lessons from the Friend virus mouse model
... + T cells play a critical role in retroviral immunity, but only recently has the complexity of this subpopulation begun to be rea- ...+ T cell have now been defined in mouse retrovirus ...+ T ... See full document
12
Regulation of CD8+ T cell responses to Toxoplasma gondii
... of CD8 + T cells and their differentiation into effector and memory ...of CD8 + T cell expansion as well as memory ...factors T-bet and Eomesodermin (Takemoto et ...a ... See full document
142
Demethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion
... virus-specific CD8 T cells is maintained during chronic infection, while PD-1 is rapidly downregulated on antigen-specific CD8 T cells after viral clearance during an acute ... See full document
13
Diverse Roles For T-Bet In The Immune Response To Toxoplasma Gondii
... However, during acute infection with Epstein Barr Virus (EBV) or human cytomegalovirus (HCMV), both T-bet and Eomes are highly expressed in CD8 + T cells specific for EBV or HCMV (Greenough et ... See full document
161
CC Chemokine Ligand 3 (CCL3) Regulates CD8+-T-Cell Effector Function and Migration following Viral Infection
... the regulation of immune effector function and leukocyte migration following viral infection of the central nervous system ...(14). T cells are essential in controlling the acute stage of ... See full document
11
Deletion of PTPN22 improves effector and memory CD8+ T cell responses to tumors
... the regulation of cellular metabolic pathways is key to establishing T cell ...memory T cells have enhanced mitochondrial SRC and reduced glycolytic flux as compared with effector ... See full document
12
Transcriptional and Posttranscriptional Regulation of Cytokine Gene Expression in HIV-1 Antigen-Specific CD8+ T Cells That Mediate Virus Inhibition
... Dead Cell Stain Kit; Molecular Probes) in phosphate-buffered saline for 20 min at room ...and CD8 ⫹ subsets. From the total CD4 ⫹ and CD8 ⫹ populations, the naive subset was identified as CD45RO- ... See full document
15
Selective CD28 blockade attenuates CTLA-4–dependent CD8+ memory T cell effector function and prolongs graft survival
... Memory T cells pose a significant problem to successful therapeutic control of unwanted immune responses during autoimmunity and transplantation, as they are differentially controlled by cosignaling ... See full document
15
Enhanced CD8 T-cell anti-viral function and clinical disease in B7-H1-deficient mice requires CD4 T cells during encephalomyelitis
... ongoing regulation of T cells and their adaptation to the local environment is most apparent during persist- ent infections, when CD4 T cells are essential to prolong CD8 ... See full document
17
Persistence of Transgene Expression Influences CD8+ T-Cell Expansion and Maintenance following Immunization with Recombinant Adenovirus
... -secreting CD8 ⴙ T ...antigen-specific CD8 ⫹ T cells produced by our rHuAd5 vectors can express TNF- ␣ and that very few produce IL-2 (51, ...Since CD8 ⫹ T cells exposed to ... See full document
10
Phenotypic Definition of Effector and Memory T-Lymphocyte Subsets in Mice Chronically Infected with Mycobacterium tuberculosis
... Flow cytometry for surface markers and intracellular cytokines. For flow cytometry analysis, single-cell suspensions of lung from each mice were resus- pended in PBS (Sigma-Aldrich) containing 0.1% of sodium ... See full document
8
Intravaginal immunization with HPV vectors induces tissue resident CD8+ T cell responses
... investigated CD8 + T cell responses in the female mouse cervicovaginal mucosa after intravaginal immunization with human papillomavirus vectors (HPV pseudoviruses) that transiently expressed a model ... See full document
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