[PDF] Top 20 Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase.
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Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase.
... Furthermore, we detected protein kinase activity in PP2A immunoprecipitates and protein phosphatase activity in src immune complexes from extracts of middle T-antigen-transformed, but no[r] ... See full document
10
Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A.
... Amino acid residues in region 1 and region 2 of MT are important for MT-mediated transformation. To study the ef- fect of these mutations on MT-mediated transformation, mu- tant ST sequences were transferred into an MT ... See full document
8
Multimerization of polyomavirus middle-T antigen.
... mutant middle-T antigen were transiently or stably expressed in NIH 3T3 ...shorter protein were subse- quently used to immunoprecipitate the expressed T ...Fig. 2A, full-length ... See full document
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Catalytically Inactive Protein Phosphatase 2A Can Bind to Polyomavirus Middle Tumor Antigen and Support Complex Formation with pp60c-src
... the phosphatase activity in immunoprecipitates of epitope-tagged wild-type and mutant C ...the phosphatase activities and is representative of the other ...blots. Phosphatase activities of the ... See full document
9
A Transformation-Defective Polyomavirus Middle T Antigen with a Novel Defect in PI3 Kinase Signaling
... ABSTRACT Middle T antigen (MT), the principal oncoprotein of murine polyomavi- rus, transforms by association with cellular ...proteins. Protein phosphatase 2A (PP2A), YAP, Src ... See full document
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Mutation of a cysteine residue in polyomavirus middle T antigen abolishes interactions with protein phosphatase 2A, pp60c-src, and phosphatidylinositol-3 kinase, activation of c-fos expression, and cellular transformation.
... 1945-1952 0022-538X/93/041945-08$02.00/0 Copyright © 1993, American Society for Microbiology Mutation of a Cysteine Residue in Polyomavirus Middle T Antigen Abolishes Interactions with P[r] ... See full document
8
Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP
... intestinal phosphatase (CIP) and lambda phosphatase treatment and subsequent extended SDS-PAGE and Western blotting to detect ...wild type without ... See full document
14
Binding of Polyomavirus Small T Antigen to Protein Phosphatase 2A Is Required for Elimination of p27 and Support of S-Phase Induction in Concert with Large T Antigen
... the middle, and the small T antigens (LT, MT, and ST, ...large T antigens of SV40 and Py but also for the E1A protein of adenovirus and for the E7 protein of human papil- ... See full document
8
Amino-terminal regions of polyomavirus middle T antigen are required for interactions with protein phosphatase 2A.
... The polyomavirus MT coding region was cloned into Bluescript KS as a XhoI-EcoRI fragment from pMTneoMLV (15, 22) for subsequent ...from polyomavirus DNA con- taining the 3 9 untranslated region and the ... See full document
8
Functional interaction between the SH2 domain of Fyn and tyrosine 324 of hamster polyomavirus middle-T antigen.
... including phosphatase 2A (8, 31, 47), Src-related tyrosine kinases (reviewed in reference 12), PI 3-kinase (8, 48), phos- pholipase C- g 1 (2, 42), and 14-3-3 proteins ...adapter protein SHC (3, 13), ... See full document
8
Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen
... its interaction with PP2A A ␣ , we generated 29 alanine substitutions in MCV sT (Table ...sT protein stability and limited our ability to assess interactions and functional activities for these mu- tants ... See full document
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Novel monoclonal antibodies that differentiate between the binding of pp60c-src or protein phosphatase 2A by polyomavirus middle T antigen.
... Since the sites recognized by these MAbs have been localized to a small region of MT, it has been possible to search a protein data base for corresponding amino acid sequences.. Identica[r] ... See full document
10
Transgenic Expression of Polyomavirus Middle T Antigen in the Mouse Prostate Gives Rise to Carcinoma
... MT-induced lesions exhibit features of adenocarcinomas characterized by luminal cell markers. We next sacrificed mice at various ages to assess whether MT drives tumorigenesis in the mouse prostate. At 4 weeks, the ... See full document
12
Therapeutic relevance of the protein phosphatase 2A in cancer
... has been known to cause spindle assembly checkpoint failure [34]. In addition, S137D ensures elevated kinase activity rather than simply overexpressing PLK1 protein [35]. However, prior to testing the SDL ... See full document
18
Mutations which affect the inhibition of protein phosphatase 2A by simian virus 40 small-t antigen in vitro decrease viral transformation.
... MUMBY,2 AND KATHLEEN RUNDELL'* Department of Microbiology-Immunology and The Cancer Center, Northwestern University, Chicago, Illinois 60611-3008,l and Department of Pharmacology, Univer[r] ... See full document
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mlt Mutation in the polyomavirus genome impairing a function of the middle T protein.
... 242-246 0022-538X/84/070242-05$02.00/0 Copyright C 1984, American Society for Microbiology JOURNAL mlt Mutation in the Polyomavirus Genome Impairing a Function of the Middle T Protein CE[r] ... See full document
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Overproduction of polyomavirus middle T antigen in mammalian cells through the use of an adenovirus vector.
... The hybrid transcription unit incorporated in Ad5PyMTR1 and Ad5PyMTR2 should be expressed predominantly at late times after infection of 293 cells to yield a hybrid mRNA composed of 2,89[r] ... See full document
14
Polyomavirus middle-T antigen associates with the kinase domain of Src-related tyrosine kinases.
... hemagglutinin protein (HA tag) together with a sequence coding for an 11-amino-acid linker peptide, KLMGLVVMNIT, in frame to the 5 9 end of the truncated c-src coding ... See full document
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Zinc-binding and protein-protein interactions mediated by the polyomavirus large T antigen zinc finger.
... expressed protein which should be unmodified can form hexamers (42); this argues against the first ...with polyomavirus LT- expressing baculoviruses from Sf9 cells also argue against such direct ...wild ... See full document
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Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain.
... tiny T antigen ...muPy T antigens in infected or transformed cells did not detect tiny T antigen, probably because the electro- phoretic separation and detection systems were not ... See full document
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