[PDF] Top 20 Characterization of Primary Isolate-Like Variants of Simian-Human Immunodeficiency Virus
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Characterization of Primary Isolate-Like Variants of Simian-Human Immunodeficiency Virus
... of simian-human immunodeficiency virus (SHIV) that contain the envelope glyco- proteins of either T-cell-line-adapted (TCLA) strains or primary isolates of human ... See full document
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Characterization of a Novel Simian Immunodeficiency Virus with a vpu Gene from Greater Spot-Nosed Monkeys (Cercopithecus nictitans) Provides New Insights into Simian/Human Immunodeficiency Virus Phylogeny
... one virus previously determined to be “pure” has actually been derived from early recombinations between ancestral viruses, “paren- tal” viruses characterized afterward will be identified as recom- ... See full document
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Common Themes of Antibody Maturation to Simian Immunodeficiency Virus, Simian-Human Immunodeficiency Virus, and Human Immunodeficiency Virus Type 1 Infections
... of virus-specific immune responses to human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) is important to understanding the early ... See full document
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Cyclophilin A-Independent Replication of a Human Immunodeficiency Virus Type 1 Isolate Carrying a Small Portion of the Simian Immunodeficiency Virus SIVMACgag Capsid Region
... chimeric virus, which has 18 bp of SIV gag CA sequence in place of the region encoding the HIV-1 CA cyclophilin A (CyPA)-binding loop, was infectious for human cell ...chimeric virus was unable to ... See full document
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Neutralizing Antibodies in Sera from Macaques Infected with Chimeric Simian-Human Immunodeficiency Virus Containing the Envelope Glycoproteins of either a Laboratory-Adapted Variant or a Primary Isolate of Human Immunodeficiency Virus Type 1
... for human immunodeficiency virus type 1 (HIV-1) is to generate an effective neutralizing antibody ...the virus are major targets for neutralizing antibodies (for a review, see reference 3) and ... See full document
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DC-SIGN Interactions with Human Immunodeficiency Virus Type 1 and 2 and Simian Immunodeficiency Virus
... for virus trans- mission, a cell line which inducibly expresses DC-SIGN was ...efficient virus transmission, cells were seeded in duplicate wells and DC-SIGN expression was induced by addition of ...the ... See full document
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Use of Inhibitors To Evaluate Coreceptor Usage by Simian and Simian/Human Immunodeficiency Viruses and Human Immunodeficiency Virus Type 2 in Primary Cells
... Like human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency viruses (SIV) and human immunodeficiency virus type 2 (HIV-2) use ... See full document
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CCR5 Signal Transduction in Macrophages by Human Immunodeficiency Virus and Simian Immunodeficiency Virus Envelopes
... CCR5-utilizing isolate that fails to replicate in ...this isolate enters MDMs but does not complete reverse tran- ...M-tropic isolate JR-FL, suggesting that a threshold level of signaling through ... See full document
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V3-independent determinants of macrophage tropism in a primary human immunodeficiency virus type 1 isolate.
... Human immunodeficiency virus type 1 isolates differ in their ability to productively infect macrophages, and several groups have mapped the genetic basis for macrophage tropism to regions of env that ... See full document
7
Determinants of Entry Cofactor Utilization and Tropism in a Dualtropic Human Immunodeficiency Virus Type 1 Primary Isolate
... for human immunodeficiency virus type 1 (HIV-1) tropism has been clarified recently with the discovery that chemokine receptors, members of the large seven-trans- membrane family of G-protein-coupled ... See full document
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Characterization of Antibody Responses Elicited by Human Immunodeficiency Virus Type 1 Primary Isolate Trimeric and Monomeric Envelope Glycoproteins in Selected Adjuvants
... uncloned virus stocks derived from PBMC cultures, as described ...However, virus YU2 was a recombinant Env-pseudovirus encoding a green fluorescent protein (GFP) re- porter gene ...(37). Virus ... See full document
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Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys
... the human glioma cell line NP-2/CD4 with specific chemo- kine coreceptor expression of CCR5, CXCR4, or GPR15, or with no chemokine receptor (provided by Feng Gao) (34), as well as HOS cell- derived Ghost(3) cells ... See full document
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CXCR4-Dependent Infection of CD8+, but Not CD4+, Lymphocytes by a Primary Human Immunodeficiency Virus Type 1 Isolate
... most primary T cells, as discussed above, expression of CCR5 is limited to a very small fraction of the CD4 ⫹ T ...93US143-T8 isolate was able to infect CD4 ⫹ lymphocytes independently of CXCR4 ... See full document
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Whole-Genome Characterization of Human and Simian Immunodeficiency Virus Intrahost Diversity by Ultradeep Pyrosequencing
... Next, we extracted all envelope sequences and utilized the Geno2Pheno [454] tool to determine the tropism of the virus infecting each patient (Table 1) (9). Tropism determined by hundreds of sequences per patient ... See full document
6
Adaptation of a CCR5-Using, Primary Human Immunodeficiency Virus Type 1 Isolate for CD4-Independent Replication
... CCR5 binding of gp120 glycoproteins from CD4-indepen- dent viruses. The ability of HIV-1 gp120 to bind CCR5 is dependent on prior CD4 binding (68, 72). To examine whether the acquisition of CD4 independence influenced ... See full document
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Characterization of Simian Immunodeficiency Virus SIVSM/Human Immunodeficiency Virus Type 2 Vpx Function in Human Myeloid Cells
... Vpx and for the positive effect of Vpx-VLP preincubation on infection with HIV-1. The different vectors were produced by the transfection of 293T cells and purified through a double-sucrose cushion. They were then ... See full document
11
Heterogeneous Spectrum of Coreceptor Usage among Variants within a Dualtropic Human Immunodeficiency Virus Type 1 Primary-Isolate Quasispecies
... env variants did not differ from the highly charged V3 sequence of ...time variants with a range of tropisms and other biological characteristics may still be retained within the population represented by ... See full document
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Induction of Antibodies in Guinea Pigs and Rhesus Monkeys against the Human Immunodeficiency Virus Type 1 Envelope: Neutralization of Nonpathogenic and Pathogenic Primary Isolate Simian/Human Immunodeficiency Virus Strains
... recombinant virus; the CAT conversion values for assays with neutralizing antisera were divided by the CAT conversion values for the corresponding preimmune ... See full document
10
Vaccine-Elicited V3 Loop-Specific Antibodies in Rhesus Monkeys and Control of a Simian-Human Immunodeficiency Virus Expressing a Primary Patient Human Immunodeficiency Virus Type 1 Isolate Envelope
... developed simian-human immunodeficiency viruses (SHIVs) provide powerful tools for assessing the potential role of V3 loop-specific antibodies in vaccine-elicited protective ...a simian ... See full document
11
Induction and Characterization of Neutralizing Antibodies against a Human Immunodeficiency Virus Type 1 Primary Isolate
... FIG. 1. DH012 neutralization by the chimpanzee serum C1206 (15wk) in the presence of V3 peptides. A multinuclear activation of a galactosidase indicator assay (MAGI assay) (22) was used to study the neutralizing activity ... See full document
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