[PDF] Top 20 Chimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence.
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Chimeric cDNA studies of Theiler's murine encephalomyelitis virus neurovirulence.
... ROOS* Department ofNeurology/MC2030, University of Chicago Medical Center, Chicago, Illinois 60637 Received 26 January 1993/Accepted 29 March 1993 Strain GDVII and other members of the G[r] ... See full document
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Theiler's Murine Encephalomyelitis Virus L* Amino Acid Position 93 Is Important for Virus Persistence and Virus-Induced Demyelination
... Theiler’s murine encephalomyelitis virus (TMEV) induce a persistent central nervous system infection associated with an inflammatory white matter demyelin- ating ...mutant virus from our ... See full document
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Apoptotic and Antiapoptotic Activity of L Protein of Theiler's Murine Encephalomyelitis Virus
... wt virus infection but not infection with DA ⌬ L virus, suggesting that DA L led to apoptosis of HeLa ...in studies involving transfection of DA L expression constructs and in TUNEL ...GDVII ... See full document
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A Subgenomic Segment of Theiler's Murine Encephalomyelitis Virus RNA Causes Demyelination
... the virus genes or gene products of TMEV or other picornaviruses cause death or dysfunction of cells within an animal are ...Our studies suggest that DA RNA (the 5 ⬘ UTR or the coding region of the RNA) ... See full document
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Inducible nitric oxide synthase in Theiler's murine encephalomyelitis virus infection.
... Theiler’s murine encephalomyelitis virus (TMEV) infection of susceptible (SJL) and resistant (C57BL/6 [B6]) strains of ...of virus-induced demyelinating disease, such as multiple sclerosis ... See full document
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Theiler's murine encephalomyelitis virus-induced cardiac and skeletal muscle disease.
... A virus infection, perhaps by inducing a pathogenic immune response, has been implicated in the pathogenesis of the hu- man idiopathic inflammatory ...leukemia virus type 1 (HTLV-1) has been localized in ... See full document
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Theiler's murine encephalomyelitis virus kills restrictive but not permissive cells by apoptosis.
... Theiler’s murine encephalomyelitis viruses (TMEV), genus Cardiovirus , family Picorniviridae , are natural enteric pathogens of mice which cause central nervous system demyelination similar to that seen in ... See full document
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Theiler's murine encephalomyelitis virus subgroup strain-specific infection in a murine macrophage-like cell line.
... be virus antigen ...Further studies are required to clarify whether the restricted replication in macrophages in a differ- entiated, activated state is due to the production of a cytokine that limits TMEV ... See full document
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L* Protein of the DA Strain of Theiler’s Murine Encephalomyelitis Virus Is Important for Virus Growth in a Murine Macrophage-Like Cell Line
... affect virus growth in J774-1 ...for virus growth in J774-1 ...GDVIIL/DAFSSC virus, which contains the L coding region of GDVII substituted for that of DA, is severely restricted in J774-1 ...DAL*-1 ... See full document
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DNA Vaccination against Theiler’s Murine Encephalomyelitis Virus Leads to Alterations in Demyelinating Disease
... our studies, divergent immune responses, including alteration in cytokine microenvironment, might be induced with pCMV/VP constructs, leading to different mod- ulation in TMEV-induced demyelinating ... See full document
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The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease.
... Ultrastructural studies of TMEV-infected adult SJL mice have not revealed virus parti- cles, have demonstrated only rare examples of degenerating oligodendrocytes (35), and have provided conflicting ... See full document
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Alternative translation initiation site in the DA strain of Theiler's murine encephalomyelitis virus.
... We now provide support for this proposal from experiments involving in vitro translation of three separate mutations of an infectious DA cDNA clone: DA"l"-1, which contains a base mismat[r] ... See full document
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Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities
... group-specific virus growth, Obuchi et al constructed a recombinant virus, DANCL*/GD, which has DA 5' non- coding and L* coding regions in the background of GDVII (with synthesis of ...DANCL*/GD ... See full document
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Identification of a Novel Neuropathogenic Theiler's Murine Encephalomyelitis Virus
... In summary, our study reports the discovery and character- ization of a novel, highly neurovirulent TMEV, the first report of a new strain in this subgroup in more than 70 years. Criti- cally, we characterized the ... See full document
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Pathogenesis of Chimeric MHV4/MHV-A59 Recombinant Viruses: the Murine Coronavirus Spike Protein Is a Major Determinant of Neurovirulence
... hepatitis virus (MHV) spike glycoprotein, S, has been implicated as a major determinant of viral ...the S gene of MHV4, a highly neurovirulent strain, into the genome of MHV-A59, a mildly ... See full document
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Distinct Attenuation Phenotypes Caused by Mutations in the Translational Starting Window of Theiler’s Murine Encephalomyelitis Virus
... this virus are due largely, if not exclusively, to point mutations in the viral capsid (1, 10, ...same virus can induce quite different diseases depending on minute changes in coding (GDVII versus BeAn and ... See full document
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Alternative Translation Initiation of Theiler’s Murine Encephalomyelitis Virus
... Theiler’s murine encephalomyelitis virus (TMEV) produce a chronic demyelinating disease in which the virus persists but has a restricted ...for virus persistence and the induction of ... See full document
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The Leader Polypeptide of Theiler's Murine Encephalomyelitis Virus Is Required for the Assembly of Virions in Mouse L Cells
... these studies that deletion of the leader sequences reduces viral translation, but that an even more striking defect is at the level of virus ...of virus production observed in mouse ...to ... See full document
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Influence of Theiler's murine encephalomyelitis virus 5' untranslated region on translation and neurovirulence.
... Our previous results from chimeric cDNA studies had indicated that GDVII 1B-2C has a major role in determining neurovirulence but that the addition of GDVII sequences 5' to this also con[r] ... See full document
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Infectious cDNA clones of the DA strain of Theiler's murine encephalomyelitis virus.
... Construction of pDAFL3, an infectious cDNA clone DA strain in a transcription vector, in which pDAFL1 was reengineered so that the 5' end of the DA genome was placed two nucleotides down[r] ... See full document
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