[PDF] Top 20 Circular RNAs: analysis, expression and potential functions

... circRNA expression in the brains of flies, mice, pigs and humans (Szabo et ...2015). Analysis of mouse brains from embryonic day (E) 18 to postnatal day (P) 30 revealed that the largest changes in circRNA ... See full document

... that circular RNAs are closely linked to many serious diseases, especially cancers ...non-coding RNAs (ncRNAs), covalently closed circular RNA mole- cules (circRNAs), have stable and highly ... See full document

... RPMS1 expression context, backsplicing read counts (underarches) derived from RNase R-seq data sets are plotted with forward splicing (overarches) and coverage data (exon color intensity) derived from poly(A)-seq ... See full document

... the expression characteristic of circular RNAs (circRNAs) in peripheral blood of type 2 diabetes mellitus (T2DM) patients and their potentials as diagnostic biomarkers for pre-diabetes and ... See full document

... regulatory functions, closed circular structure, high stability, involvement in lung cancer development and progression, and differential expression in lung can- cer tissues, circRNAs have the ... See full document

... The expression levels of novel transcripts in each develop- mental stage increased before the 8-cell stage and then de- creased ...[36] analysis revealed that among these 2322 novel genes, ...coding ... See full document

... For the first time, Ahmed, et al., performed a robust cir- cRNAs expression analysis in clinical ovarian tumors. They reported that abundant number of circRNAs differ- entially expressed in tumor samples. ... See full document

... in-depth analysis of ncRNAs in CRC has not been reported to ...(lncRNA), circular RNA (circRNA), pRNA, and ...gene expression levels via chromatin modification, transcription, and posttranscriptional ... See full document

... gene expression patterns of GCs may be used as potential biomarkers to predict oo- cyte developmental capacity and consequent assistant reproduction results [75, ...the expression pattern of circRNAs ... See full document

... noncoding RNAs and protein-coding genes or messenger RNAs exists [34–37] which eventually tune the expression of target ...regulated expression of tumor suppressors and oncogenes is critical ... See full document

... unencapsidated circular single-stranded RNAs of about 240-400 nucleotides with extensive internal base pairing resulting in rod-like secondary ...host functions for their replication ...subviral ... See full document

... RNA, circular RNA (circRNA) is a endogenous non-coding RNA with circular structure, which has the characteristics of universality, stability, conservatism and ...the expression of related ...gene ... See full document

... 18 potential binding sites via a luciferase screening ...‘sponge’ functions of hsa_circ_0001982 in the tumorigenesis and progres- ...GFRA1 expression through the ceRNA mechanism ... See full document

... Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), are ubiquitously expressed in eukaryotic cells during post-transcriptional ...linear RNAs, circRNAs form covalent-closed ... See full document

... cellular functions, the circRNAs would need to be expressed at consequential levels within the ...its circular fraction by the density of RNA-seq reads arising from the cognate gene locus (measured in ... See full document

... of potential future research interest is related to context-related changes in ...proposed potential mechanisms concerning regulation of circRNA ...the expression of many circRNAs could be regulated ... See full document

... as potential miRNA sponges MicroRNAs (miRNAs) are ~22nt long post- transcriptional regulators of gene expression that guide an effector silencing complex containing the Argonaut protein to the 3’ ... See full document

... Figure 2. CircRNAs perform a series of biological functions. (A) Since primary RNA transcripts are generated by transcription, these immature products undergo “back-splicing”, which competitively suppresses linear ... See full document

... selected RNAs, and these differentially expressed mRNAs, miRNAs, and lncRNAs may act as potential targets or mar- kers of ...enrichment analysis of misregulated mRNAs revealed that the main abnormal ... See full document

... 1,800 circular RNAs were analyzed. The ratio of circular to linear RNA isoforms was significantly lower in tumors compared to normal colon samples and much lower in colorectal cancer cell lines and ... See full document