[PDF] Top 20 Clinical review: Severe asthma

... acute, severe asthma, but it is not pre- dictive of ...acute, severe asthma, analysis of arterial blood gases usually reveals mild hypoxemia, hypocapnia and respiratory ...patient’s ... See full document

... The addition of extrinsic PEEP in the setting of auto-PEEP may reduce work of breathing and possibly even prevent gas- trapping by splinting the airways open [29]. In terms of reducing the work of breathing, the addition ... See full document

... avoidance of the symptoms associated with moderate-to- severe allergic asthma. While respondents placed the most value on avoidance of daytime symptoms, they also reported a higher WTP to avoid waking up in ... See full document

... Ansarin K., Attaran D., Jamaati H., and Masjedi M.R., equally contributed to session moderatorship, literature review and plenary talks as well as summary of recommendations (sorted alphabetically as first-order ... See full document

... cancer. Asthma is no exception, with the advent of omalizumab a few years ago, and anti-cytokine and anti-cytokine receptor antibodies more ...in clinical practice and in phase 3 studies has revealed the ... See full document

... eosinophilic asthma [74–76, 88], no effect was observed on lung function or airway ...with severe asthma with o12% reversibility in baseline FEV 1 ...between asthma exacerbations and lung ... See full document

... Severe asthma is reported, to date, in 5%–15% of the total asthmatic population and is estimated to account for > 60% of the total costs of the disease, primarily required for medications and ... See full document

... in severe exacerbations, compared with placebo, over 48 ...PC20). Asthma Quality of Life Questionnaire (AQLQ) did improve and this was attributed to better exacerbation ... See full document

... in severe asthma 75,76 includes an increase in airway smooth muscle mass, which is associated with impaired lung function, airway hyperresponsiveness, and poor symptom ...in clinical outcomes after ... See full document

... a clinical feature of severe respiratory diseases such as asthma, cystic fibrosis and chronic obstructive pulmonary ...present review provides a summary of the most clinically relevant ... See full document

... potential clinical relevance is periostin, a protein suggested as a marker of excessive Th2- type inflammation in asthma ...in severe asthmatics with high periostin levels compared to those with low ... See full document

... The relevance of the real life studies is particularly critical in SA, where most of clinical data come from large controlled studies. However, as recently empha- sized, there is a long distance between the ... See full document

... Thirty one (31) children were randomised into prednisolone group and thirty (30) children into budesonide group and treated accordingly (see figure 12). The baseline characteristics of both the groups were comparable as ... See full document

... two clinical visits in the past 12 months, and/or a positive response to a bronchial challenge with either methacholine or mannitol during the previous ...in asthma exacerbation rates of either 47% or 53%, ... See full document

... in asthma pathophysiolo- ...The Severe Asthma Research Program demonstrated the potential clinical relevance of this pathway by showing that BMI was inversely related to FeNO levels in ... See full document

... This study found that the administration of nebu- lized continuous albuterol by heliox to moderately to severely ill asthmatic children, early in the course of their ED care, resulted in a substantial clinical im- ... See full document

... smears for screening of Plasmodium parasites, with a detec- tion limit of 10–50 trophozoites/µl. Thin smears allow one to identify malaria species (including the diagnosis of mixed infections), quantify parasitemia, and ... See full document

... its clinical efficacy in asthmatic patients in number of ...challenging clinical issue, we have arranged a pilot observational- study following clinical and laboratory data of 12 patients with ... See full document

... Abstract: Asthma is a chronic inflammatory disorder of the airways with variable clinical severity from very mild and occasional symptoms to recurrent critical exacerbations, at risk of fatal or near-fatal ... See full document

... that asthma re- presents a syndrome, and there is clinical and pathobiological ...with asthma, and may be involved in the disease ...of asthma inde- pendently of each other or they can also ... See full document