[PDF] Top 20 Comparative efficacy of long-acting bronchodilators for COPD - a network meta-analysis
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Comparative efficacy of long-acting bronchodilators for COPD - a network meta-analysis
... the network meta-analysis was biased by systematic dif- ferences between studies, the meta-regression analysis was based on study level data which has ...regarding COPD ... See full document
18
Comparative efficacy of inhaled medications (ICS/LABA, LAMA, LAMA/LABA and SAMA) for COPD: a systematic review and network meta-analysis
... random-effects network meta-analysis combining direct and indirect evi- dence was conducted to examine the change from baseline in trough FEV 1 , transition dyspnea index, St George’s Respiratory ... See full document
29
Comparative efficacy of aclidinium versus glycopyrronium and tiotropium, as maintenance treatment of moderate to severe COPD patients: a systematic review and network meta-analysis
... Another inherent limitation of systematic reviews is the presence of heterogeneity. The degree of heterogeneity between studies included in the NMA was evaluated during the validity assessment step of the current study. ... See full document
19
Comparative efficacy of combination bronchodilator therapies in COPD: a network meta-analysis
... Bayesian network meta-analysis (NMA), the published evi- dence on the efficacy of the fixed combination of UMEC/VI (55/22 μ g OD) with that of all available dual-bronchodilator combinations in ... See full document
19
Comparative efficacy of inhaled corticosteroid and long-acting beta agonist combinations in preventing COPD exacerbations: a Bayesian network meta-analysis
... overall efficacy of each ICS/LABA com- bination was assessed (all strengths of each combination combined), all but BDP/FM reduced moderate-to-severe exacerbations (Figure ...overall efficacy of each ... See full document
11
Comparative efficacy of long-acting muscarinic antagonist monotherapies in COPD: a systematic review and network meta-analysis
... Primary comparative efficacy data from randomized controlled trials for newer LAMAs are ...clinical efficacy between all ...relative efficacy for important clinical endpoints. A number of ... See full document
23
Comparative efficacy of long-acting β2-agonists as monotherapy for chronic obstructive pulmonary disease: a network meta-analysis
... of COPD, and exacerbation ..., meta-regression analyses of study- level data can be prone to ecological bias (ie, the association between the study-level effect patient characteristics and treatment effects ... See full document
15
The impact of incorporating Bayesian network meta-analysis in cost-effectiveness analysis - a case study of pharmacotherapies for moderate to severe COPD
... the analysis should include all available treatment options; and the evidence synthe- sis should be based on all the available evidence ...PMA meta-analyses may however fall short in these two ...on ... See full document
9
Efficacy and safety profile of xanthines in COPD: a network meta-analysis
... on long-acting bronchodilators ...present meta-analysis, there is a clear need to understand what is the room in the treatment of COPD for a xanthine that induces the same, if ... See full document
12
<p>Relationship of inhaled long-acting bronchodilators with cardiovascular outcomes among patients with stable COPD: a meta-analysis and systematic review of 43 randomized trials</p>
... From the electronic database (PubMed, Embase database and Cochrane), a total of 1,545 studies were identi fi ed, as shown in Figure S1. No additional studies that met the inclusion criteria were found by manual search. In ... See full document
10
Safety, effectiveness, and cost of long-acting versus intermediate-acting insulin for type 1 diabetes: Protocol for a systematic review and network meta-analysis
... with long-acting insulin analogues, such as glargine and detemir ...[4]. Long-acting insulin analogues are more expensive than intermediate-acting insulin [3], yet have a slower ... See full document
5
Efficacy of once-daily indacaterol 75 μg relative to alternative bronchodilators in COPD: A study level and a patient level network meta-analysis
... Chronic obstructive pulmonary disease (COPD) is a lung disease characterized by airflow limitation which is not fully reversible, involving breathlessness, decreased exer- cise capacity, and in some cases chronic ... See full document
15
Impact of prior and concurrent medication on exacerbation risk with long-acting bronchodilators in chronic obstructive pulmonary disease: a post hoc analysis
... of long-acting bronchodilator given once-daily using identical ...hoc meta-analyses have shown that LAMA/LABAs are well tolerated com- pared with monotherapy [10] and can improve lung function and ... See full document
11
Long-acting bronchodilators improve exercise capacity in COPD patients: a systematic review and meta-analysis
... on COPD), there is a rationale to expect a better efficacy of ICS/LABA FDCs rather than LABA alone on exercise ...recent meta-analysis LABA/ LAMA FDCs were found to be more effective than LABA ... See full document
12
Comparison of efficacy of long-acting bronchodilators in emphysema dominant and emphysema nondominant chronic obstructive pulmonary disease
... and/or long-term oxygen therapy, and respiratory tract infection or exacerbation during the pre- ceding three ...open-label, comparative trial of the clinical efficacy of tiotropium and salmeterol in ... See full document
9
The inevitable drift to triple therapy in COPD: an analysis of prescribing pathways in the UK
... When the pathways to TT were further examined accord- ing to mMRC scores (dyspnea) and lung function impairment, it was observed that these had no impact on the pathways to TT, with ICS plus LABA → TT being the most ... See full document
11
Characteristics, disease burden and costs of COPD patients in the two years following initiation of long-acting bronchodilators in UK primary care
... with COPD initiated on LABD alone or LABA+ICS treatment and explored the impact of adher- ence on healthcare resource use and ...of COPD management were high but consistent with recent studies completed in ... See full document
10
Efficacy of bronchoscopic lung volume reduction: a meta-analysis
... our meta-analysis was designed to compare different methods used for BLVR, most of the studies included in our meta-analysis studied one-way ...our meta-analysis favor BioLVR as ... See full document
11
Inhaled treatment of COPD: a Delphi consensus statement
... for COPD. Long-acting bronchodilators are recommended as a first-choice treatment for COPD patients without frequent and/or severe exacerbations, regardless of symptoms, with ... See full document
9
Effectiveness of long-term using statins in COPD – a network meta-analysis
... We used the multiple treatment meta-analysis method (MTM) proposed by Salanti et al. (a Bayesian method based on the Markov Chain Monte Carlosimulation) to compare testing modalities for effect from statins ... See full document
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