[PDF] Top 20 Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors
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Complement Is an Essential Component of the Immune Response to Adeno-Associated Virus Vectors
... Adeno-associated virus (AAV) vectors are associated with relatively mild host immune responses in ...innate immune responses, neutralizing antibodies against the vector ... See full document
14
Novel Strategy for Generation and Titration of Recombinant Adeno-Associated Virus Vectors
... Adeno-associated virus (AAV) is a member of the depen- dent parvovirus family that requires coinfection with a helper virus, such as adenovirus or herpesvirus, to undergo a produc- tive ... See full document
9
The TLR9 MyD88 pathway is critical for adaptive immune responses to adeno associated virus gene therapy vectors in mice
... interfere with the TLR9-MyD88 pathway may improve the outcome of AAV-mediated gene therapy in humans. As a first step to test- ing this strategy, we examined whether AAV also activated human pDCs via TLR9. Human pDCs and ... See full document
12
Adeno-Associated Virus Activates an Innate Immune Response in Normal Human Cells but Not in Osteosarcoma Cells
... in response to the presence of the corresponding ligands enclosed in such ...an essential role in inducing type I IFNs and the ensuing adaptive response to AAV ... See full document
11
Lack of Repeat Transduction by Recombinant Adeno-Associated Virus Type 5/5 Vectors in the Mouse Airway
... viral vectors can be repeatedly ...rAAV2/2 vectors (15, ...mune response that inhibits successive rounds of transduction ...and/or immune-modulating agents, including CTLA4Ig (16), or broad ... See full document
8
Biodistribution and Safety Profile of Recombinant Adeno-Associated Virus Serotype 6 Vectors following Intravenous Delivery
... mune response genes (30), while in vivo, transient induction of chemokine and cytokine transcription is seen in livers of mice after intravenous delivery (38), indicating activation of innate ...A ... See full document
5
Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration.
... an immune response and it would not occur in ...other immune responses, such as the acute lung inflammation seen after administration of adenovirus vectors, were not observed after delivery of ... See full document
10
The state of the art of adeno associated virus based vectors in gene therapy
... adenoviral vectors, and turn it into a very attractive tool for gene ther- ...AAV vectors only retain about 300 nucleotides of viral sequence in the form of nontranscribed ITRs, which greatly improves its ... See full document
7
Repeated Delivery of Adeno-Associated Virus Vectors to the Rabbit Airway
... by complement fixation or neutralization assays, indicating that natural AAV infection is common in humans (7, 9, 38, ...body response or that multiple infections are common (7, ...rAAV vectors to ... See full document
10
Double-stranded RNA innate immune response activation from long-term adeno-associated virus vector transduction
... using adeno-associated virus (AAV) vectors have demonstrated decreased transgenic coagulation factor IX (hFIX) expression 6–10 weeks after administration of a high vector ...innate ... See full document
16
Repeat Transduction in the Mouse Lung by Using Adeno-Associated Virus Vectors with Different Serotypes
... weak immune response resulted in reduced transduction rates when animals were given a vector with the cross-reactive se- ...neutralizing immune response, and this was correlated with its ... See full document
9
Gangliosides Are Essential for Bovine Adeno-Associated Virus Entry
... bovine adeno-associated virus (BAAV), which is serologically distinct from primate AAVs ...cross- complement the replication and packaging of ...that vectors based on BAAV could be ... See full document
7
Differential Activation of Innate Immune Responses by Adenovirus and Adeno-Associated Virus Vectors
... adenovirus vectors prompted us to embark on the studies in this report ...AAV vectors induced the expressions of various chemokines in two epithelium-derived cell lines, REC and ...of adeno- ... See full document
11
CpG depleted adeno associated virus vectors evade immune detection
... innate immune response, as evidenced by the produc- tion of proinflammatory cytokines, including IL-1β and IL-6, as well as the chemokines MIP-1 and ...innate immune cells in response to TLR9 ... See full document
9
Expression Profiles of Bovine Adeno-Associated Virus and Avian Adeno-Associated Virus Display Significant Similarity to That of Adeno-Associated Virus Type 5
... nonprimate-derived adeno-associated viruses, namely, bovine adeno-associated virus (B-AAV) and avian adeno-associated virus (A-AAV), which were obtained after the ... See full document
12
Herpes Simplex Virus Type 1/Adeno-Associated Virus Hybrid Vectors Mediate Site-Specific Integration at the Adeno-Associated Virus Preintegration Site, AAVS1, on Human Chromosome 19
... simplex virus type 1 (HSV-1)-based amplicon vec- tors are bacterial plasmids that contain two HSV-1 cis ele- ments, an origin of DNA replication (ori), and a DNA pack- aging/cleavage signal ...helper virus ... See full document
11
Reducing the Risk of Adeno-Associated Virus (AAV) Vector Mobilization with AAV Type 5 Vectors
... TR2 vectors, but not TR5, are mobilized by latent wt AAV2 and Ad ...helper virus (4, ...to complement rAAV vector genomes when assayed by Southern blot ... See full document
11
Adeno-associated virus vectors transduce primary cells much less efficiently than immortalized cells.
... P]dCTP, 1.5 U of Taq polymerase, and 125 ng of each neo primer, Neo1 and Neo5). In addition, 10 fg of plasmid pLASDN (27) was added to all samples as a competitor for vector amplification. Amplification entailed 25 to 30 ... See full document
7
Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants.
... Among these mutants, we distinguished at least three phenotypes: i mutants that were defective in their ability to rescue or replicate the AAV genome from the recombinant plasmids rep mu[r] ... See full document
11
Improving clinical efficacy of adeno associated vectors by rational capsid bioengineering
... host immune response compared to AAV8 and AAV9 at lower IVIG ...AAV vectors by shuffling capsid sequences of AAV1,2,4,5,6,8 and ...mutant vectors with a greater than 90% similarity to AAV1/6 ... See full document
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