[PDF] Top 20 Does Binding of Complement Factor H to the Meningococcal Vaccine Antigen, Factor H Binding Protein, Decrease Protective Serum Antibody Responses?
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Does Binding of Complement Factor H to the Meningococcal Vaccine Antigen, Factor H Binding Protein, Decrease Protective Serum Antibody Responses?
... fH binding elicited antibodies with greater bactericidal activity than the control fHbp vaccine that bound ...fHbp vaccine that bound fH, with the mutant vaccine that did not bind human fH, ... See full document
9
Heterogeneity in Rhesus Macaque Complement Factor H Binding to Meningococcal Factor H Binding Protein (FHbp) Informs Selection of Primates To Assess Immunogenicity of FHbp-Based Vaccines
... resist complement by recruiting the complement downregulator factor H (FH) to the bacterial ...studies, binding of FH to one of the major meningococcal FH ligands, factor ... See full document
7
Impaired Immunogenicity of a Meningococcal Factor H-Binding Protein Vaccine Engineered To Eliminate Factor H Binding
... of binding of fH to fHbp-based vaccines on their immunogenicity in humans is ...that does not bind fH may have increased immunoge- nicity by exposing fHbp epitopes that ordinarily are not avail- able when ... See full document
5
Molecular Engineering of Ghfp, the Gonococcal Orthologue of Neisseria meningitidis Factor H Binding Protein
... two protein-based vaccines approved for use in humans, one (Trumenba) licensed in the United States for use in individuals 10 through 25 years of age (4, 5), and the second (Bexsero) recom- mended in ⬎30 countries ... See full document
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A Critical Threshold of Meningococcal Factor H Binding Protein Expression Is Required for Increased Breadth of Protective Antibodies Elicited by Native Outer Membrane Vesicle Vaccines
... NOMV vaccine from a mutant with attenuated endotoxin activity ( ⌬ LpxL1), which also was engineered to overexpress fHbp (21, ...the serum bactericidal antibody response was directed against LOS, with ... See full document
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Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein
... (14). Serum antibodies from 4CMenB- vaccinated macaques with FH that bound weakly to the vaccine elicited greater activation of the classical complement pathway and higher bactericidal activity than ... See full document
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A Meningococcal Outer Membrane Vesicle Vaccine with Overexpressed Mutant FHbp Elicits Higher Protective Antibody Responses in Infant Rhesus Macaques than a Licensed Serogroup B Vaccine
... wo meningococcal serogroup B vaccines are licensed in North America and ...is factor H binding protein (FHbp), and the fourth is detergent-extracted outer membrane vesicles (dOMV) ...to ... See full document
13
Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein
... therapeutic responses to steroid ...or serum anti-FH antibody level determined, and one of the cases relapsed and required long-term immunosuppression ...potential vaccine safety ...of ... See full document
14
Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding
... inhibit binding of FH to meningococci. In previous studies, serum anti-FHbp antibodies, which were elicited in WT mice whose mouse FH didn’t bind to the FHbp vaccine antigen, inhibited ... See full document
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Human Factor H (FH) Impairs Protective Meningococcal Anti FHbp Antibody Responses and the Antibodies Enhance FH Binding
... B vaccine candidates is ne- cessitated by observations that antibodies to the serogroup B cap- sular polysaccharide cross-react with glycosylated mammalian proteins such as the neural cell adhesion molecule (2) ... See full document
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Binding of the von Willebrand Factor A Domain of Capillary Morphogenesis Protein 2 to Anthrax Protective Antigen Vaccine Reduces Immunogenicity in Mice
... PA vaccine to enhance the conformational stability of PA is likely to decrease the efficacy of any anthrax vaccine containing ...of antibody formation when sCMG2 is complexed to PA could be ... See full document
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A case report of recurrent C3 glomerulonephritis 18 months after renal transplantation
... requiring complement activation could provoke or aggravate a related disease such as ...the complement cascade, and C3 production is upregulated first in the mesangial cells and vessels and 2 days later in ... See full document
6
Factor H autoantibodies and deletion of Complement Factor H Related protein 1 in rheumatic diseases in comparison to atypical hemolytic uremic syndrome
... inhibit complement inhibitory activity of FH in the fluid phase but rather blocked binding of FH to C3bBb convertase [16] and to cell surfaces ...enhanced complement activation, a lower local ... See full document
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... Mannan – binding lectin (MBL) is an important molecule of innate immunity. It stimulates the classical complement pathway as an opsonin. It also acts as a weak App. It plays a role in the defense against ... See full document
5
Quantitative proteomics analysis of vitreous body from type 2 diabetic patients with proliferative diabetic retinopathy
... To our knowledge, this research was the first quantita- tive proteomics analysis to study the protein distribution which could obtain a brief understanding of protein con- tent and sample reliability. A ... See full document
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Analysis of the Ability of Spirochete Species Associated with Relapsing Fever, Avian Borreliosis, and Epizootic Bovine Abortion To Bind Factor H and Cleave C3b
... the binding of the complement regulatory protein factor H (fH) to the cell sur- face (1, 2, 7, 8, 10, ...a complement regulatory protein that serves as a cofactor for the ... See full document
6
Development of a Multi Plex Electrochemiluminescent Assay for the Detection of Serum Antibody Responses to Meningococcal Conjugate Vaccines
... Infections caused by the bacterium Neisseria meningitis- dis remain an important medical need, particularly in the developing world where periodic outbreaks are responsi- ble for thousands of deaths [1]. Despite the ... See full document
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Binding of Staphylococcus aureus Protein A to von Willebrand Factor Is Regulated by Mechanical Force
... vWF binding to SpA is tightly mechanoregulated: the bond is weak at low tensile force, but is dramatically increased at high ...The binding site of these adhesins is a cleft of 30 Å in length between the N2 ... See full document
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Polyhydroxyalkanoate beads as a particulate vaccine against Streptococcus pneumoniae and Neisseria meningitidis : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Microbiology at Massey University, Manawatu, New Zealand
... carrier protein (conjugate vaccine) provided an efficient strategy to prevent the ...of meningococcal disease, is not included in any conjugate vaccine as the CPS is similar to polysaccharides ... See full document
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Polyhydroxyalkanoate beads as a particulate vaccine against Streptococcus pneumoniae and Neisseria meningitidis : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Microbiology at Massey University, Manawatu, New Zealand
... ii proteins on the PHB bead surface, while the CPS was covalently attached by chemical conjugation. Mice vaccinated with these PHB beads produced strong and antigen-specific antibody levels. In addition, ... See full document
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