[PDF] Top 20 Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication.
Has 10000 "Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication." found on our website. Below are the top 20 most common "Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication.".
Conditional human immunodeficiency virus type 1 protease mutants show no role for the viral protease early in virus replication.
... Table 1, neither the wild-type virus nor the V32I/V82I mutant showed any decrease in infectivity when the infection was done in the presence of the PR inhibitor at concentrations between ...inhibits ... See full document
5
Intracellular expression of human immunodeficiency virus type 1 (HIV-1) protease variants inhibits replication of wild-type and protease inhibitor-resistant HIV-1 strains in human T-cell lines.
... indicating viral cytopathic effects ...not show these effects but did display continuously increasing levels of HIV-1 p24 antigen .../ml) replication by 2 to 3 orders of magnitude as ... See full document
8
Individual Contributions of Mutant Protease and Reverse Transcriptase to Viral Infectivity, Replication, and Protein Maturation of Antiretroviral Drug-Resistant Human Immunodeficiency Virus Type 1
... (1/5, 1/25, and 1/125) and added to a 96-well plate with poly(rA) (enzyme template) bound to the bottom of the wells and with 150 l of reaction solution containing bromodeoxyuridine triphosphate as ... See full document
10
Intravirion Processing of the Human Immunodeficiency Virus Type 1 Vif Protein by the Viral Protease May Be Correlated with Vif Function
... All mutants were created by two-step PCR mutagenesis as described in Materials and ...the mutants analyzed in this study is listed in Table ...concentrated virus preparations ...lanes 1 and 7) ... See full document
12
Evolution of Human Immunodeficiency Virus Type 1 Protease Genotypes and Phenotypes In Vivo under Selective Pressure of the Protease Inhibitor Ritonavir
... and replication capacity of molecular clones with pro sequences derived from treated subjects at different ...on viral fitness and susceptibility to other ...NC-p1 protease cleavage ... See full document
12
Autoprocessing of human immunodeficiency virus type 1 protease miniprecursor fusions in mammalian cells
... of protease activity in ...mature protease activity and/or pro- tease autoprocessing efficiency ...HIV protease plays a critical role in viral infec- tivity, protease inhibitors ... See full document
10
Altered Substrate Specificity of Drug-Resistant Human Immunodeficiency Virus Type 1 Protease
... all viral cleavage sites, and their occurrence correlates specifically with protease in- hibitor therapy ...of protease in- hibitor-resistant viruses (7, 11, 23, ...in protease specificity and ... See full document
10
Human Immunodeficiency Virus Type 1 Group M Protease in Cameroon: Genetic Diversity and Protease Inhibitor Mutational Features
... the role of distinct Cameroon- ian HIV-1 strains in the contribution of PR amino acid mutations that are linked to PI resistance, we estimated such substitutions in viral strains harboring both ... See full document
9
Constrained Evolution of Human Immunodeficiency Virus Type 1 Protease during Sequential Therapy with Two Distinct Protease Inhibitors
... the human immunodeficiency virus type 1 (HIV-1) protease (PR) are among the most active antiretro- viral compounds used in the therapy of HIV-1 infection ... See full document
5
Resistance-Associated Loss of Viral Fitness in Human Immunodeficiency Virus Type 1: Phenotypic Analysis of Protease andgag Coevolution in Protease Inhibitor-Treated Patients
... SQV-resistant virus 487 displayed a cleav- age site mutation located at the P19 position of the p1/p6 cleavage site (L to F) in addition to the MA/CA ...the virus to survive in an increasingly selective ... See full document
6
In vivo sequence diversity of the protease of human immunodeficiency virus type 1: presence of protease inhibitor-resistant variants in untreated subjects.
... HIV-1 protease have become available and have shown some initial promise in clin- ical trials (5, 30, 41, ...of viral RNA per milliliter of plasma and increases in the number of CD4 1 cells in ... See full document
6
Wild-Type-Like Viral Replication Potential of Human Immunodeficiency Virus Type 1 Envelope Mutants Lacking Palmitoylation Signals
... with 1% Triton X-100 on ice, and extracted cell lysates were analyzed by sucrose gradient ...Cys-to-Ser mutants were analyzed in parallel, all of the mutant Env proteins were localized in the lipid rafts ... See full document
14
A Mutation in Human Immunodeficiency Virus Type 1 Protease, N88S, That Causes In Vitro Hypersensitivity to Amprenavir
... patients 1 and 14 carried both K20T and N88S substitutions and generated modest amounts of lu- ciferase activity, although the activity was markedly less than that of the control (data not ...these mutants ... See full document
6
Effect of Mutations in the Human Immunodeficiency Virus Type 1 Protease on Cleavage of the gp41 Cytoplasmic Tail
... analysis. Viral lysates were prepared and immunoblotted with antibody (Ab) specific to the N ter- minus of ...R237L mutants in the context of the AD8 strain undergo gp41 CT cleavage, although the extent of ... See full document
6
Inhibition of human and simian immunodeficiency virus protease function by targeting Vpx-protease-mutant fusion protein into viral particles.
... simian immunodeficiency virus (HIV and SIV) Gag and Pol proteins are synthesized as precursor polyproteins that are cleaved into mature products by the viral protease (7, 25, 28, ...into ... See full document
7
A Functional Role for ADAM10 in Human Immunodeficiency Virus Type 1 Replication
... To determine if ADAM10 is required for proviral DNA integration, genomic and small non-genomic cDNA was isolated from cells at various time points post-infection. If HIV-1 cDNA enters the nucleus but does not ... See full document
14
Role of the DIS hairpin in replication of human immunodeficiency virus type 1.
... this type of ...and virus spread was assayed by measurement of the virion-associated CA-p24 levels in the culture ...both mutants compared with wild-type HIV-1 ..., 1 m g), we ... See full document
10
Determinants of the human immunodeficiency virus type 1 p15NC-RNA interaction that affect enhanced cleavage by the viral protease.
... proposed role for the intra- Cys-His basic array is that viruses with mutations in this region should show specific defects in processing, namely, in p15NC ...mutant virus have concluded that ... See full document
10
Second locus involved in human immunodeficiency virus type 1 resistance to protease inhibitors.
... against human immunodeficiency virus type ...to protease inhibitors can develop and is attributed to the appearance of mutations in the protease ...analog protease ... See full document
8
Genetic correlates of in vivo viral resistance to indinavir, a human immunodeficiency virus type 1 protease inhibitor.
... the human immunodeficiency virus type 1 (HIV-1) ...During early clinical trials, in which patients initiated therapy with suboptimal dosages of IDV, we monitored the ... See full document
7
Related subjects