[PDF] Top 20 Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function
Has 10000 "Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function" found on our website. Below are the top 20 most common "Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function".
Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function
... of HLA-B*13 on HIV-1 disease progression are mediated in part by fitness costs of CTL escape mutations in conserved Gag epitopes, but other mechanisms remain incompletely ... See full document
15
Impaired Nef Function Is Associated with Early Control of HIV-1 Viremia
... affect Nef function in this ...by HLA-A*31 and B*37 were required to reduce the ability of Nef to downregulate HLA class ...for escape mutations that directly ... See full document
14
CD8+T cells from HLA B*57 elite suppressors effectively suppress replication of HIV 1 escape mutants
... nonsynonymous mutations in epitopes enable the virus to escape from the cytotoxic T lymphocyte (CTL) ...these escape mutations play in de- termining protection versus progression in ... See full document
12
Functional Consequences of Human Immunodeficiency Virus Escape from an HLA-B*13-Restricted CD8+ T-Cell Epitope in p1 Gag Protein
... of escape variants with better replicative capacity despite only modestly reduced CTL recognition: virus containing the K346R or I437V muta- tion arises in 25% of clade C virus-infected B*13 ... See full document
8
Pressure from TRIM5α Contributes to Control of HIV-1 Replication by Individuals Expressing Protective HLA-B Alleles
... of HIV-1 sensitivity to hTRIM5 ␣ in patients that did or did not express protective HLA-B alleles and to assess the possibility that selective pressure exerted by this restric- tion factor ... See full document
13
Spontaneous control of HIV 1 viremia in a subject with protective HLA B plus HLA C alleles and HLA C associated single nucleotide polymorphisms
... I/LW9 B*57 associ- ated epitope, restoring the original IW9 epitope with little or no impact on viral escape or fitness reported in prior ...synonymous mutations in the plasma virus [22-25]. It is ... See full document
9
Spontaneous control of HIV-1 viremia in a subject with protective HLA-B plus HLA-C alleles and HLA-C associated single nucleotide polymorphisms
... I/LW9 B*57 associ- ated epitope, restoring the original IW9 epitope with little or no impact on viral escape or fitness reported in prior ...synonymous mutations in the plasma virus [22-25]. It is ... See full document
9
Uncommon Pathways of Immune Escape Attenuate HIV-1 Integrase Replication Capacity
... immune escape at the population level ...that HLA-associated RC de- fects occur in RT-integrase sequences obtained from HIV-1 elite controllers (12); however, the integrase protein has ... See full document
11
Transmission of HIV-1 CTL escape variants provides HLA-mismatched recipients with a survival advantage.
... through HLA-B*57/5801-positive individuals and provide evidence that they have enabled better control of viral replication for up to at least a year following transmission to their current ...of ... See full document
12
Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals
... identified HLA-B*58:01 as a protective HIV allele. However, not all B*58:01-expressing persons exhibit slow HIV disease ...six HLA-B*58:01-positive, HIV subtype ... See full document
12
Virological and Immunological Factors Associated with HIV-1 Differential Disease Progression in HLA-B*58:01-Positive Individuals
... identified HLA-B*58:01 as a protective HIV allele. However, not all B*58:01-expressing persons exhibit slow HIV disease ...six HLA-B*58:01-positive, HIV subtype ... See full document
11
Evolution of the HIV 1 nefgene in HLA B*57 Positive Elite Suppressors
... in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape ...Baker B, Rothchild AC, Li B, Trocha A, Cutrell E, Frahm N, Brander C, Toth I, Arts EJ, Allen TM, Walker ... See full document
7
Impact of HLA-B*81-Associated Mutations in HIV-1 Gag on Viral Replication Capacity
... Brumme, b,c Jessica ...Brockman, b,c Eric Hunter, d and Thumbi Ndung’u a,e HIV Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson ...Canada b ; BC Centre for Excellence in ... See full document
7
Relative Resistance of HLA B to Downregulation by Naturally Occurring HIV 1 Nef Sequences
... ABSTRACT HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the sur- face of virus-infected cells, thus evading immune detection ... See full document
12
Counteraction of HLA-C-Mediated Immune Control of HIV-1 by Nef
... all HIV-1 constructs contained intact env genes and were thus replication competent following the first round of ...pseudotyped HIV-1 was performed under laminar flow hoods by ... See full document
12
The Hypervariable HIV-1 Capsid Protein Residues Comprise HLA-Driven CD8+ T-Cell Escape Mutations and Covarying HLA-Independent Polymorphisms
... that HIV polymorphisms may arise in the context of a complex set of interrelated substitu- tions that reflect structural dependencies among amino ...into HIV-HLA association ...the ... See full document
7
CD8⁺ T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope
... immunodominant HIV-1 subtype B Nef epitope VY8 (VPLRPMTY) presented by HLA-B * ...336 HIV-1- infected individuals revealed variability at position (P) 3 and P8 of ... See full document
6
Potent Enhancement of HIV 1 Replication by Nef in the Absence of SERINC3 and SERINC5
... that HIV-1 Nef counteracts the antiviral host proteins SERINC3 and ...potent Nef-like activity on HIV-1 ...for Nef in promoting HIV-1 replication in ... See full document
14
Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1
... related HLA alleles, a number of limitations merit men- ...and Nef and was restricted to a cohort of clade C-in- fected ...high-resolution HLA data reduces statistical power for most rare alleles, a ... See full document
14
In vivo analysis of highly conserved Nef activities in HIV 1 replication and pathogenesis
... of Nef ’s capacity to enhance viral replication and deplete CD4 + T cells and CD4 + CD8 + ...the Nef activities that account for the remainder of Nef ’s effects are ...active Nef, ... See full document
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