[PDF] Top 20 Control of HIV-1 in Elite Suppressors despite Ongoing Replication and Evolution in Plasma Virus
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Control of HIV-1 in Elite Suppressors despite Ongoing Replication and Evolution in Plasma Virus
... of HIV-1-infected patients known as elite controllers or suppressors (ES) control the virus ...and plasma gag clones in ES, much of which can be attributed to selective ... See full document
11
Evolution of the HIV 1 nefgene in HLA B*57 Positive Elite Suppressors
... the control of the HIV- 1 replication in elite suppressors are not fully under- stood ...[1-3]. Replication competent virus has been isolated from some ES ... See full document
7
Factors Leading to the Loss of Natural Elite Control of HIV-1 Infection
... viral evolution have been associated with viral pathogenesis and disease progression ...viral evolution since primoinfection (18, ...of control, showed evidence of viral divergence and diversity in ... See full document
18
Isolation and Characterization of Replication-Competent Human Immunodeficiency Virus Type 1 from a Subset of Elite Suppressors
... harbor replication-competent viruses strongly suggests that host factors may be playing a key role in the control of viral replication in ...reference HIV-1 strains replicated well in ... See full document
11
Neutralizing Antibodies Do Not Mediate Suppression of Human Immunodeficiency Virus Type 1 in Elite Suppressors or Selection of Plasma Virus Variants in Patients on Highly Active Antiretroviral Therapy
... autologous virus can reach high titers in human immunodeficiency virus type 1 (HIV-1)-infected patients with progressive ...in HIV-1-infected patients with viral loads of ... See full document
13
Effective Downregulation of HLA-A*2 and HLA-B*57 by Primary Human Immunodeficiency Virus Type 1 Isolates Cultured from Elite Suppressors
... ficiency virus type 1 (HIV-1)-infected individuals who maintain normal CD4 ⫹ T-cell counts and remain asymptomatic for longer than 10 years without therapy ...of HIV-1 RNA in ... See full document
6
Evidence of CD8+ T-Cell-Mediated Selective Pressure on Human Immunodeficiency Virus Type 1 nef in HLA-B*57+ Elite Suppressors
... autologous HIV-1 isolates that are lower than those of patients with progressive disease (2); thus, it is unlikely that the humoral immune response can explain the control of viral replication ... See full document
10
Role of APOBEC3G/F-Mediated Hypermutation in the Control of Human Immunodeficiency Virus Type 1 in Elite Suppressors
... imal HIV-1 evolution and characteristic APOBEC3G-induced hypermutation in one LTNP ...in elite sup- pressors (ESs) had substantial levels of hypermutation ...with replication-competent ... See full document
6
CD8+T cells from HLA B*57 elite suppressors effectively suppress replication of HIV 1 escape mutants
... the virus to escape from the cytotoxic T lymphocyte (CTL) ...C HIV-1 infection ...ES, virus amplified from the plasma of the same subjects contained a high frequency of escape mutations ... See full document
12
Circulating Monocytes Are Not a Major Reservoir of HIV-1 in Elite Suppressors
... of HIV-1 infection and contributors to disease pathogenesis (20–22, 25, 42, 47, ...as HIV-1 reservoirs that preclude viral eradication in HIV-1-infected patients despite ... See full document
5
Identification of Ongoing Human Immunodeficiency Virus Type 1 (HIV-1) Replication in Residual Viremia during Recombinant HIV-1 Poxvirus Immunizations in Patients with Clinically Undetectable Viral Loads on Durable Suppressive Highly Active Antiretroviral Therapy
... the HIV-1 RT region, the sensitivities of the low-level viremia genotyping and viral load assays, the lack of a placebo group to fully assess sequence evolution at viremia levels of ⬍ 50 copies/ml ... See full document
12
Prolonged persistence of a novel replication defective HIV 1 variant in plasma of a patient on suppressive therapy
... for HIV in the natural ...G’s plasma frequently (5 of 7 occasions), we failed to de- tect the same mutation in residual plasma vRNAs of three other patients (not shown) on suppressive therapy, ... See full document
13
Potent inhibition of human immunodeficiency virus type 1 (HIV-1) replication by inducible expression of HIV-1 PR multimers.
... to HIV-1 ...mutated HIV-1 which is resistant to the effects of this gene is highly ...an HIV-1 strain to develop resistance, the amino acid sequence of many PR cleavage sites ... See full document
7
Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Replication by HIV-1-Based Lentivirus Vectors Expressing Transdominant Rev
... less HIV-1 replication in cells transduced with ...of HIV-1 replication displayed by cSR9–3C with respect to cSR7 might have been caused by the higher fraction of unprotected ... See full document
10
Persistent Replication of Human Immunodeficiency Virus Type 1 despite Treatment of Pulmonary Tuberculosis in Dually Infected Subjects
... of HIV-1/TB-coinfected patients based on reduction in HIV-1 viral load by the end of anti-TB ...in HIV-1 viral load by 6 months ...of HIV-1 disease ... See full document
7
Primary CD8+ T cells from elite suppressors effectively eliminate non productively HIV 1 infected resting and activated CD4+T cells
... Figure 2 Elimination of non-productively infected CD4 + cells. (A) Representative FACS plots demonstrating the gating scheme employed for the calculation of normalized percent elimination. Cells in culture were stained ... See full document
12
Suppressors of a Host Range Mutation in the Rabbitpox Virus Serpin SPI-1 Map to Proteins Essential for Viral DNA Replication
... positive control to generate wild-type virus or the parental SPI-1 T309R mutant gene as a negative control, which should not generate ...negative control, were detected on A549 cells by ... See full document
12
Engineering Chimeric Antigen Receptors For Durable Control Over Hiv-1 Replication
... of HIV DNA decay were found to be 10 times as rapid for SB-728- treated patients who maintained suppressed viremia (did not undergo STI) compared to control aviremic patients who did not receive ... See full document
190
Detection of Replication Competent Human Immunodeficiency Virus Type 1 (HIV 1) in Cultures from Patients with Levels of HIV 1 RNA in Plasma Suppressed to Less Than 500 or 50 Copies Per Milliliter
... We studied the frequency of positive PBMC cultures in a subset of subjects enrolled in a phase III clinical trial which compared triple therapy with indinavir and two nucleosides to dual-nucleoside therapy alone. In this ... See full document
6
Rapid development of HIV elite control in a patient with acute infection
... the HIV-positive popu- lation (< 1%), suppress HIV viremia below 50 copies per ml in the absence of ART ...developed elite control and were followed longitudinally from early ... See full document
6
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