[PDF] Top 20 The Cryptococcus neoformans Transcriptome at the Site of Human Meningitis

... in human CSF, the in vivo gene expression profile would be more similar to that ob- served in ex vivo CSF than YPD, which is nutritionally ...C. neoformans mutants to survive in vitro in human CSF ... See full document

... of Cryptococcus are encapsulated yeasts that normally reside in the environment, where they readily become airborne and can infect humans through ...the human risks for increased susceptibility to ... See full document

... and human-to-human transmis- sion is not important in the disease ...and site of a given niche in the environment, along with dispersal from the niche as an infectious propagule, will deter- ... See full document

... susceptibility profiles. Because the short time in between each isolation it is suggestive that this was not a recur- rent infection, it is possible that the patient was infected simultaneously with both strains. ... See full document

... insertion site was identified in strain 2a13, revealing a chromosomal rearrangement between chromosomes 2 and 8 in- volving two nonessential genes (YTP1 and HCM1) in ...in transcriptome sequencing (RNA-seq) ... See full document

... C. neoformans TFs uncovered several mutants exhibiting altered susceptibility to genotoxic stresses ...pathogenic Cryptococcus species ...C. neoformans UPR pathway, in which the evolutionarily ... See full document

... by transcriptome analysis upon early infection ...C. neoformans-macrophage interac- tions and cryptococcosis have been performed with mice, no tan- gible biological evidence of dormancy has been brought to ... See full document

... ABSTRACT Cryptococcus neoformans and Cryptococcus gattii are globally distributed human fungal pathogens and the leading causes of fungal ...C. neoformans can utilize myo-inositol as a ... See full document

... C. neoformans and ...The human strains, 77 serotype A and 93 serotype D, were iso- lated from 134 patients, hospitalized in 21 different cities, mainly in northern and central ... See full document

... ABSTRACT Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompro- mised ...C. neoformans but exert a fungistatic effect, necessitating ... See full document

... C. neoformans strains. Clinical cultures were collected during the prospective multicenter CryptoA/D study implemented at the National Reference Center for Mycoses and Antifungals (NRCMA) between 1997 and 2001 ... See full document

... in Cryptococcus neoformans and identified four melanin-regulating core transcription factors (TFs), Bzp4, Usv101, Mbs1, and Hob1, required for induc- tion of the laccase gene ...sequencing-based ... See full document

... Bacteremia without endocarditis; recovered after appropriate therapy 8 16 F None Meningitis Cryptococcus neoformans Antigen nega- Later cultures positive on 1 tive, antiregular media bod[r] ... See full document

... pathogen Cryptococcus neoformans, host alveolar macrophages compartmentalize Cu to the phagosome, and the ability to detoxify Cu is critical for its survival and ...C. neoformans in a manner that ... See full document

... C. neoformans during each episode of disease and that this was not reflected in the single-colony isolates tested from primary isolation ...C. neoformans colonies recovered on primary ...C. ... See full document

... C. neoformans, many of the ROS response transcripts are predicted to possess extensively structured 5= untranslated regions (UTR) with uORF, such as the oxidative stress response transcript ERG110, which would ... See full document

... predominant human pathogenic fungi, namely, Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, this pathway is required for many functions associated with pathogenesis and ... See full document

... In this present study, we used disk diffusion tests, the commercial Etest kit that has been described as a good method for routine laboratory use, proving to have a good alternative for in vitro sensitivity tests for ... See full document

... In conclusion, Cryptococcal meningitis is a opportunistic infection with high mortality and morbidity. Combination of amphotericine B 0.7 to 1 mg/kg of body weight/day for 2 weeks and Fluconazole (800-1200mg/day) ... See full document

... Indeed, Park, et al. estimate that up to a million cases of meningitis due to C. neofor- mans occur annually, primarily in patients with AIDS, among whom more that 600,000 die within the first three months (3). In  ... See full document