[PDF] Top 20 Current research progress on hypoxia and tumor
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Current research progress on hypoxia and tumor
... of tumor cells, such as the enhancement of proliferative capacity and the uninhibited growth of tumor cells, the metabolic levels and related signaling pathways in the tumor microenvironment have ... See full document
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Progress toward overcoming hypoxia-induced resistance to solid tumor therapy
... therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, ... See full document
12
Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models
... of tumor progres- sion and angiogenesis, and is associated with cancer resistance towards radiotherapy and chemotherapy ...make tumor cells adapt to this condition by upregulating the production of numerous ... See full document
10
The impact of hypoxia on tumor associated macrophages
... moral hypoxia still represents an obstacle to better categorization and characterization of hypoxic TAMs in cancer ...years, tumor specimens have been characterized with different macrophage markers and ... See full document
9
Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
... conditions, tumor cells undergo a series of adaptations that promote evolution of a more aggressive tumor phenotype including the activation of DNA damage repair proteins, altered metabolism, and decreased ... See full document
10
Current relevance of hypoxia in head and neck cancer
... a hypoxia radiosensitizer, during ...the tumor radiosensitizer ...with hypoxia in 4 nasopharyngeal cancer cell lines ...[134]. Tumor hypoxia increases metastasis and Courter et ... See full document
24
Epithelial-Mesenchymal Transition in tumor microenvironment
... reports, hypoxia may be proposed as a second factor in the initiation of ...that hypoxia-induced EMT in renal epithelial cells depend on hypoxia-inducible factors (HIF) signal- ing partly ...and ... See full document
7
Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions
... Autophagy is important in cellular homeostasis and facilitating cell survival in adverse conditions [15–19] including hypoxia [20–23]. The effect of autophagy on tumors is controversial. Autophagy functions as ... See full document
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Elucidating Ubiquitin Chain Formation Catalyzed by E2 Enzymes through use of a Di Ubiquitin Probe
... no studies to date have performed a rigorous comparison of CA in OPSCCs that differed in their HPV status, nor have they investigated the prognostic role of CA in HPV +ve/-ve OPSCCs after accounting for potential ... See full document
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Detecting functional changes with [18F]FAZA in a renal cell carcinoma mouse model following sunitinib therapy
... monitoring tumor metabolism in RCC with [ 18 F]FDG, [ 18 F]FMISO was used to analyze effects on tumor oxygenation status and [ 18 F]FLT for determination of ...imaging tumor hypoxia ...a ... See full document
11
The role of autophagy induced by tumor microenvironment in different cells and stages of cancer
... on hypoxia-inducible factors (HIFs), whereas anoxia-induced autophagy is HIF independent ...moderate hypoxia, which disrupts the Beclin 1/Bcl-2 complex, releasing Beclin1 and activating autophagy [28-31], ... See full document
11
Hypoxia-activated prodrugs and redox-responsive nanocarriers
... Abstract: Hypoxia is one of the marked features of malignant tumors, which is associated with several adaptation changes in the microenvironment of tumor ...targeting tumor hypoxia is a ... See full document
24
Original Article Correlation between BOLD-MRI and HIF expression level in renal carcinoma
... the hypoxia treatment of ...of tumor cells, is thus of critical importance for optimizing treat- ment strategy, evaluating efficacy and predict- ing ... See full document
5
From antiangiogenesis to hypoxia: current research and future directions
... as a strategy for cancer therapy, which is the fundamental premise of antiangiogenesis therapy. This unconventional approach seemed promising for several reasons. First, fewer side effects were expected from inhibiting ... See full document
8
Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma
... dalantercept. Tumor vascular networks compromised by the AVMs would be less efficient in the delivery of oxygen and nutrients to tumor ...the tumor tissues using the hypoxia probe, EF5 ... See full document
13
Predictive biomarkers for tumor immune checkpoint blockade
... international research as well as clinical trials to discuss the current status and progress of PD-L1 expression as a biomarker for tumor immunotherapy and also to discuss whether tumor ... See full document
7
The Neuroimaging Center of the Pediatric Brain Tumor Consortium–Collaborative Neuroimaging in Pediatric Brain Tumor Research: A Work in Progress
... imaging research plan that re- sponds to the therapeutic interventions being advanced by the PBTC, 3) ensuring that every PBTC protocol has incorporated imaging end points, and 4) facilitating a QA plan that ad- ... See full document
5
Recent Research and Updates on Alzheimer’s Disease
... Researchers at the Institute of Neuroscience of the University of Barcelona have ascertained “the cellular mechanism involved in memory consolidation” (Saito, 2014, p. 1) and that memory loss can be reversed through gene ... See full document
11
Taxonomy and ecology of Australian marine microalgae : with emphasis on harmful blooms and translocation via ship's ballast water
... Research in Progress My current research interests June 2002 are addressing the widespread potentially ichthyotoxic dinoflagellate Pfiesteria in Australian waters, toxic PSP dinoflagella[r] ... See full document
19
Synthesis, Characterization and Antiproliferative Activity of Some Novel 2-(Substitutedphenyl)-5-Methyl-3-(Phenylamino)-1,3-Thiazolidin-4-Ones
... A mixture of phenylhydrazine (1) (0.01 mol) and different aromatic aldehydes (2a-g) (0.01 mol) (4-chlorobenzaldehyde (2a), 2,3-dichlorobenzaldehyde (2b), 2,4-dichlorobenzaldehyde (2c), 4-bromobenzaldehyde (2d), ... See full document
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