[PDF] Top 20 The Human Cytomegalovirus Major Immediate-Early Distal Enhancer Region Is Required for Efficient Viral Replication and Immediate-Early Gene Expression
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The Human Cytomegalovirus Major Immediate-Early Distal Enhancer Region Is Required for Efficient Viral Replication and Immediate-Early Gene Expression
... regulatory region containing the modulator was replaced with the basal SV40 early promoter (-138 to ⫹57), bacterial gpt ORF, and SV40 early intron and polyadenylation ...(14). Viral DNA was ... See full document
12
Interaction between the Human Cytomegalovirus UL82 Gene Product (pp71) and hDaxx Regulates Immediate-Early Gene Expression and Viral Replication
... is required for efficient viral replication when cells are infected at a low multiplicity ...IE gene expression during a productive infection ...upregulating viral ... See full document
11
The 5′ Untranslated Region of the Major Immediate Early mRNA Is Necessary for Efficient Human Cytomegalovirus Replication
... (KanSacB) expression cassette containing 50 nucle- otides of sequence flanking the desired insertion site to guide recombination into the HCMV ...the region containing the KanSacB cassette followed by ... See full document
14
A Strong Negative Transcriptional Regulatory Region between the Human Cytomegalovirus UL127 Gene and the Major Immediate-Early Enhancer
... The human CMV MIE enhancer and the flanking regions were assigned arbitrary boundaries to better discuss this com- plicated regulatory region (52, ...control region from ⫹8 to ⫹112 referred to ... See full document
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Two Gamma Interferon-Activated Site-Like Elements in the Human Cytomegalovirus Major Immediate-Early Promoter/Enhancer Are Important for Viral Replication
... Human cytomegalovirus (HCMV) infection directly initiates a signal transduction pathway that leads to activation of a large number of cellular interferon-stimulated genes ...HCMV major ... See full document
12
Two Sp1/Sp3 Binding Sites in the Major Immediate-Early Proximal Enhancer of Human Cytomegalovirus Have a Significant Role in Viral Replication
... HCMV enhancer for MIE gene expression has been questioned ...proximal enhancer of HCMV cannot be fully com- pensated by other transcription factor binding ...is required for the ... See full document
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Isolation and characterization of a low-abundance splice variant from the human cytomegalovirus major immediate-early gene region.
... differential expression of IE18 mRNA in fibroblasts versus monocyte-derived macrophages is ...IE gene product is differentially expressed in these two cell types suggests a role for this protein in the ... See full document
5
Rat Cytomegalovirus Major Immediate-Early Enhancer Switching Results in Altered Growth Characteristics
... the major immediate-early (MIE) enhancer of cytomegalovirus (CMV) is important in determining virus tropism and latency because of its essential role in initiating the cascade of ... See full document
8
In Vivo Competence of Murine Cytomegalovirus under the Control of the Human Cytomegalovirus Major Immediate-Early Enhancer in the Establishment of Latency and Reactivation
... of human cytomegalovirus (HCMV) in an im- munocompromised host frequently leads to a variety of severe complications, such as pneumonia, hepatitis, and retinitis ...HCMV major ... See full document
6
CTCF Binding to the First Intron of the Major Immediate Early (MIE) Gene of Human Cytomegalovirus (HCMV) Negatively Regulates MIE Gene Expression and HCMV Replication
... MIE gene expres- sion, we assayed the effects of overexpression of CTCF on the MIE gene locus in transient-transfection assays with plasmid ...CTCF expression vector (pFlag-CTCF) or the vector ... See full document
13
Human Cytomegalovirus Early Protein pUL21a Promotes Efficient Viral DNA Synthesis and the Late Accumulation of Immediate-Early Transcripts
... candidate viral genes that are important for HCMV to estab- lish infection in tissue culture models of primary human cells, including fibroblasts (8, ...selected viral genes. We have recently ... See full document
12
Inhibition of Human Cytomegalovirus Immediate-Early Gene Expression by Cyclin A2-Dependent Kinase Activity
... Lytic replication of HCMV is a highly organized process and occurs in a cascade-like series of ...the expression of immedi- ate-early (IE) ...and major histo- compatibility complex (MHC) class ... See full document
15
Exon 3 of the Human Cytomegalovirus Major Immediate-Early Region Is Required for Efficient Viral Gene Expression and for Cellular Cyclin Modulation
... of viral DNA replication by real-time PCR further defines the growth restriction of the IE ⌬ 30-77 mutant virus ...the viral genome in infected cells was detected using primers and TaqMan probe ... See full document
15
Role of the Proximal Enhancer of the Major Immediate-Early Promoter in Human Cytomegalovirus Replication
... by human cytomegalovirus (HCMV), a member of the betaherpesvirus family, occurs in most individ- uals, it is usually ...latent viral genome and the switch between the latent and lytic forms of CMV ... See full document
12
The Human Cytomegalovirus Major Immediate-Early Enhancer Determines the Efficiency of Immediate-Early Gene Transcription and Viral Replication in Permissive Cells at Low Multiplicity of Infection
... the human cytomegalovirus (CMV) major immediate-early (MIE) enhancer or promoter on the efficiency of viral replication in permissive human cells, we ... See full document
13
Requirement of Multiple cis-Acting Elements in the Human Cytomegalovirus Major Immediate-Early Distal Enhancer for Viral Gene Expression and Replication
... The human cytomegalovirus (HCMV) major immediate- early (MIE) gene products, IE1 p72 and IE2 p86, are required for initiating viral replication (10, 16, 21, ... See full document
14
Roles of Polypyrimidine Tract Binding Proteins in Major Immediate-Early Gene Expression and Viral Replication of Human Cytomegalovirus
... MIE gene products that are all at the protein pro- duction ...MIE gene splicing. MIE gene splicing should be enhanced when the PTB gene is knocked down, which would result not only in higher ... See full document
12
Two Polypyrimidine Tracts in Intron 4 of the Major Immediate Early Gene Are Critical for Gene Expression Switching from IE1 to IE2 and for Replication of Human Cytomegalovirus
... the gene splic- ing of ...the expression of IE1 was not ...is required for the gene splicing to produce IE2 because its mutation (UCAAGUU) fails to express IE2 and (ii) the first Py ... See full document
11
Identification and characterization of the human cytomegalovirus immediate-early region 2 gene that stimulates gene expression from an inducible promoter.
... Although there are protein products of various sizes associated with IE2 and these gene products are detected in infected cells at early times after infection, we were able to demonstrat[r] ... See full document
8
Inhibition of human cytomegalovirus immediate early gene expression and replication by the ethyl acetate (EtOAc) fraction of Elaeocarpus sylvestris in vitro
... Several agents, such as the nucleoside analog ganciclovir (GCV), nucleotide analog cidofovir (CDV) and pyrophos- phate analog foscarnet (FOS), have been approved by the FDA for treatment of HCMV-related diseases [10]. ... See full document
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