[PDF] Top 20 Dengue Virus Structural Differences That Correlate with Pathogenesis

... elucidated, little is known about their antigenic structure. For NS4a and NS4b proteins it was shown that, despite marked amino acid sequence heterogeneity, their hydrophilicity pro- files are remarkably conserved among ... See full document

... related dengue virus serotypes (DENV1 to ...of dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS) ...three structural pro- teins (capsid, premembrane, and envelope) and ... See full document

... another correlate of disease severity may be the level of virus or viral proteins in the blood- streams of DF versus DHF patients, which in itself may result from the more successful replication and/or ... See full document

... Class II and III particles have an expanded E protein layer. Interpretation of the class III map showed that all interdimeric E protein interactions are weakened. Near the icosahedral 2-fold vertices, the E protein ... See full document

... the virus replicated with two mismatches within this region ...and pathogenesis was previously suggested by sequence comparison between an American and a South- east Asian DENV2 isolate, which were ... See full document

... small differences in T cell ...the virus is inducing other cell types in the PBMC mixture to produce cytokines which may have complicated our ...to correlate with dengue disease severity ... See full document

... strain-specific differences in virus ...to virus stability have not been experimentally tested, and they may include con- tacts at the dimer interface, between dimers, or among rafts ...identify ... See full document

... to dengue virus antigens, and serum levels of IFN-␥ in dengue virus- infected patients and dengue virus vaccine recipients have reached 50 ...production. Dengue ... See full document

... one dengue serotype elicits immunity to that serotype but does not provide long-term cross-protective immunity to the remaining ...new virus to cross reactive non-neutralising antibody from the previous ... See full document

... in dengue cases due to many factors, including in- creased air travel and climate ...[1]. Dengue virus (DENV) is a member of the Flavivirus genus of the Flaviviridae family and its genome is a ... See full document

... DV2 pathogenesis [29-32] but is useful for the determination of antibody responses to dengue vac- cine candidates ...mutant virus was used as an ...titered virus (DV2ΔLIG) to ensure all mice ... See full document

... the pathogenesis of DHF/DSS ...heterotypic virus entry and replication in Fcγ receptor-bearing macrophages, leading to enhanced viremia, antigenemia and cytokine storm ...DENV pathogenesis can a more ... See full document

... Dengue virus and Chikungunya virus share a common vector and their co-infection is being increasingly ...of Dengue virus by in silico ...in pathogenesis and progress of ... See full document

... To induce “immune unresponsiveness” to the P2/P3 re- gion gene products, we generated P2/P3 Tg mice with P2/ P3 driven by the human CMV promoter similar to the previously described P1 Tg mice using the BeAn strain of ... See full document

... reporter virus carrying a deletion within NS1 was used as a positive control, because earlier reports had described the rescue of NS1 mutations by trans-complementation (31, ...infectious virus released ... See full document

... It is known that IgG1 and IgG3 can fix complement most effectively, whereas IgG2 can fix complement to a lower extent (2, 5). The complement system has been associated with shock syndromes (15). In addition, activation ... See full document

... one dengue serotype elicits immunity to that serotype but does not provide long-term cross-protective immunity to the remaining ...new virus to cross reactive non-neutralising antibody from the previous ... See full document

... and differences among the DENVs them- selves and compared to other closely related flaviviruses forms a fundamental prerequisite for future drug design efforts to manipulate the viral proteolytic function by ... See full document

... To determine the quantities and types of antibodies made by humanized mice after infection, we used a commercially available kit for quantification of total human IgM and IgG antibodies and a modification of the same ... See full document

... of virus attachment is a valuable antiviral strategy because it forms the first barrier to block infection 8-10 ...of dengue virus sequence analysis based on E ... See full document