[PDF] Top 20 Determining the Breadth of the Respiratory Syncytial Virus-Specific T Cell Response
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Determining the Breadth of the Respiratory Syncytial Virus-Specific T Cell Response
... Respiratory syncytial virus (RSV) is the leading cause of hospitalization for lower respiratory tract infection in ...children. T cells play a critical role in clearing an acute RSV ... See full document
9
Cytotoxic T-cell response to respiratory syncytial virus in mice.
... We report here the finding of major histocompatibility complex-restricted, RSV-specific memory cytotoxic T cells in the spleens of BALB/c and C57BL mice after intranasal infection; these[r] ... See full document
5
Exposure of neonates to Respiratory Syncytial Virus is critical in determining subsequent airway response in adults
... Background: Respiratory syncytial virus (RSV) is the most common cause of acute bronchiolitis in infants and the ...in determining airway response to RSV ... See full document
10
Aged Mice Exhibit a Severely Diminished CD8 T Cell Response following Respiratory Syncytial Virus Infection
... following Respiratory Syncytial Virus Infection Ross ...USA Respiratory virus infections in the elderly result in increased rates of hospitalization and ...death. Respiratory ... See full document
7
Tissue-Specific Regulation of CD8+ T-Lymphocyte Immunodominance in Respiratory Syncytial Virus Infection
... ⫹ T lymphocytes play an important role in clearance of virus and recovery from RSV infection in both humans and in the murine ...CTL response to a protein antigen in mice is the limited number of ... See full document
10
Impairment of the CD8+ T cell response in lungs following infection with human respiratory syncytial virus is specific to the anatomical site rather than the virus, antigen, or route of infection
... pulmonary T cell dysfunction, this does not rule out the possibility of differences in PD-1 ligand expression between the lung and spleen, nor any of the other mech- anisms mentioned ...the ... See full document
8
Respiratory Syncytial Virus
... a response in the immature infant immune system (96) and their optimal use may prove to be in boosting the adult ...on virus/bacteria-like structures, mimic infective agents and may be able to induce ... See full document
27
The NS2 Protein of Human Respiratory Syncytial Virus Suppresses the Cytotoxic T-Cell Response as a Consequence of Suppressing the Type I Interferon Response
... HRSV NS2 suppresses the production of total CD8 ⴙ cells. We also evaluated the level of total pulmonary CD8 ⫹ cells in the lungs of mice that were mock infected or infected with wt HRSV, the recombinant viruses lacking ... See full document
11
The Respiratory Syncytial Virus Fusion Protein and Neutrophils Mediate the Airway Mucin Response to Pathogenic Respiratory Syncytial Virus Infection
... of the laboratory strain A2, as evidenced by greater interstitial pneumonia, increased mucin levels, and more necrotic cell debris in the airways. An increased early viral load correlated with airway necrotic ... See full document
13
Limited Breadth of a T-Helper Cell Response to a Human Immunodeficiency Virus Envelope Protein
... gp120-specific T-helper response was almost exclusively focused on a single ...immune response sufficiently diverse to recognize variant sequences among circulating ...responding ... See full document
6
Characterization of Respiratory Syncytial Virus M- and M2-Specific CD4 T Cells in a Murine Model
... CD4 T cells have been shown to play an important role in the immunity and immunopathogenesis of respiratory syncytial virus (RSV) ...CD4 T-cell epitopes in the RSV M and M2 ... See full document
8
Age related changes in T cell mediated immune response and effector memory to Respiratory Syncytial Virus (RSV) in healthy subjects
... immune response including RSV specific neutralising anti- bodies would be necessary for maintaining protective immunity in the ...RSV specific protective humoral response in elderly which, as ... See full document
8
A Systemic Neutrophil Response Precedes Robust CD8+ T-Cell Activation during Natural Respiratory Syncytial Virus Infection in Infants
... primary respiratory syncytial virus (RSV) infections are characterized by bronchiolitis accompanied by ...from virus-induced lung pathology or from excessive immune ...primary ... See full document
10
Immunodominant T-cell epitope on the F protein of respiratory syncytial virus recognized by human lymphocytes.
... Human and murine cytotoxic T cells specific to respiratory syncytial virus recognize the viral nucleoprotein (N), but not the major glyco- protein (G), expressed by vaccinia virus recomb[r] ... See full document
8
Interleukin-4 Diminishes CD8+ Respiratory Syncytial Virus-Specific Cytotoxic T-Lymphocyte Activity In Vivo
... in respiratory syncytial virus (RSV)-enhanced disease, the mechanism by which it modulates immune responses to primary RSV infection remains ...cytotoxic T-lymphocyte (CTL) effector function ... See full document
6
Neutralizing and enhancing activities of human respiratory syncytial virus-specific antibodies.
... this response was ...in determining the outcome of RSV infection was examined for infants from whom cord blood serum samples were collected at ...reported respiratory illness requiring ... See full document
7
Mapping an antibody-binding site and a T-cell-stimulating site on the 1A protein of respiratory syncytial virus.
... were immunized once with 1A(45-60), and the draining lymph node cells were tested for ability to proliferate in response to in vitro restimulation with the nested set of peptides describ[r] ... See full document
9
Respiratory Syncytial Virus Fusion Protein Mediates Inhibition of Mitogen-Induced T-Cell Proliferation by Contact
... other virus proteins was able to inhibit PHA-stimulated lymphocyte pro- liferation, whereas expression of comparable amounts of cell surface G protein did not lead to ...species-specific ... See full document
8
HLA Class I-Restricted Cytotoxic T-Cell Epitopes of the Respiratory Syncytial Virus Fusion Protein
... Respiratory syncytial virus (RSV) is a common cause of upper respiratory tract infections but may—especially in young infants, the elderly, or immunocompromised individuals— cause severe lower ... See full document
5
Airway response to respiratory syncytial virus has incidental antibacterial effects
... lower respiratory infections (ALRI) due to respiratory syncytial virus (RSV) resulted in an estimated ...of respiratory virus infection is secondary bacterial infection; viruses ... See full document
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