[PDF] Top 20 Developing and validating risk prediction models in an individual participant data meta-analysis

... Thirteen articles considered patients who were diseased at baseline; for example Sylvester et al. [33] estimate a superficial bladder cancer patient’s probability of recur- rence and progression at one and five years. ... See full document

... effects models to examine the associations of these pregnancy complications with the risk of childhood underweight, overweight and obesity in the same age ...the risk of childhood underweight, only ... See full document

... sensitivity analysis, we noticed a reduced (rather than increased) risk of DA in men and women using SF in less ventilated and non-separated kitchens (data not ...the risk of WS was signi fi ... See full document

... IPD meta-analysis methods [5 e 11], and the methods often give very similar results ...time-to-event data, Tudur Smith and Williamson [14] show through simulation that when there is no heterogeneity ... See full document

... Values are odds ratios (95% confidence intervals) from multilevel binary logistic regression models that reflect the risk of childhood overweight/obesity in early childhood (2.0-5.0 yea[r] ... See full document

... cohorts, meta-analyses with random effects models were used to derive summary HRs and RAPs ...the meta-analyses according to cohort characteristics was carried out in order to examine possible ... See full document

... a meta-analysis using IPD to assess the prognostic ability of one (or more) factors in patients with a specific disease or health ...level data across multiple studies or multiple collaborat- ing ... See full document

... the risk of LBW using pooled data from 14,633 pregnancies from 13 studies (6 cohort studies and 7 randomized controlled trials) conducted in Africa and the Western Pacific from ...regression models ... See full document

... share individual participant ...for risk of bias, quality of evidence, and strength of ...the individual participant data meta-analysis, we will use a one-step ... See full document

... Additional models were then fitted to include the other 5 studies, at the expense of reducing the number of confounders but increasing the sample ...sequential models did not include the following ... See full document

... Aggregated data meta-analysis involves synthesis of esti- mates from clinical ...aggregated data meta-analyses is that primary outcomes of clinical trials as well as sub- groups defined ... See full document

... raw data. The aim of this type of meta-analysis is to collect raw data from original studies, and then, to combine those raw data in a way to minimize the possibility of any ... See full document

... For each of the outcomes a one stage approach to analysis will be taken so that the IPD from all eligible trials are included in a single model. Fitting a single model for each outcome variable will enable the ... See full document

... lower risk for symptom deterioration compared with controls (including regular care services) and our previous study showed that is effective in treating depressive ... See full document

... IPD meta-analysis are non-trivial and depend on many factors, which perhaps explains why they are currently ...baseline risk and treatment effects) ...of analysis model ...IPD ... See full document

... the meta- analyses using the primary trial IPD available. These IPD meta-analyses will be conducted using a one-step ap- proach, where the IPD from all studies are modeled sim- ultaneously while accounting ... See full document

... Methods: Eligible studies include cross-sectional, cohort, and randomized controlled studies recording both plasma chitotriosidase activity and CCL18 level at baseline and/or at follow-up in consecutive children or adult ... See full document

... current meta-analysis, of number of patients required to demonstrate a significant impact of continuous control of P cuff on outcomes indicates that ... See full document

... Our meta-analysis of IPD demonstrates that low placebo responses are a hallmark of neuropathic pain in RCTs of individuals with chronic SCI. Contrasting the hypothesis that disease-specific factors ... See full document

... all individual studies in all analyses consistently had effect sizes (for both SoD and DtS) in the same direction (varying only in ...using meta-analysis. Furthermore, all meta-analyses showed ... See full document