[PDF] Top 20 Development of the anti-gp120 antibody response during seroconversion to human immunodeficiency virus type 1.
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Development of the anti-gp120 antibody response during seroconversion to human immunodeficiency virus type 1.
... Antibody D7324-A was used to minimize assay background in all experiments in which the binding of human serum antibodies to gpl20 was detected direct-binding assays, whereas D7324 was us[r] ... See full document
14
Development of a Neutralizing Antibody Response during Acute Primary Human Immunodeficiency Virus Type 1 Infection and the Emergence of Antigenic Variants
... of gp120 regions from the seroconversion ...the gp120 open reading frames (ORFs) were amplified by a nested reverse tran- scription-PCR (RT-PCR) as described previously (26, 40, ...the gp120 ... See full document
9
The Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody 2G12 Recognizes a Cluster of α1→2 Mannose Residues on the Outer Face of gp120
... mechanisms, as discussed earlier. However, the cluster of tightly packed oligomannose sugars in the region of the 2G12 epitope is unrepresentative of mammalian glycosylation and may, therefore, invoke an antibody ... See full document
16
Enhancement of human immunodeficiency virus type 1 envelope-mediated fusion by a CD4-gp120 complex-specific monoclonal antibody.
... Flow cytometry measurements of CG10 binding to CD4-gp120 complexes on cells expressing T-tropic or M-tropic envelopes. HeLa cells were infected over- night with the vaccinia virus recombinants described ... See full document
7
Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120
... of gp120 was evaluated ...on gp120 (9, 70, 72, 80), the anti-V3 MAb 447-52D, which neutralizes primary isolates of subtype B (30, 31), and MAb 17b, which recognizes a CD4-induced epitope and which ... See full document
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Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.
... for human immunodeficiency virus ...HIV type 1 (HIV-1), gp120, has been mapped to the C * -C ( region of domain 1 of ...of human CD4, is able to mediate ... See full document
9
Neutralization of Human Immunodeficiency Virus Type 1 by Antibody to gp120 Is Determined Primarily by Occupancy of Sites on the Virion Irrespective of Epitope Specificity
... that antibody binding to functional oligomeric gp41-gp120 complexes correlates with neutralization (16, 39, ...meric gp120 without neutralizing the virus. An anti-V2 MAb (62c) bound to ... See full document
8
Synergistic inhibition of human immunodeficiency virus type 1 envelope glycoprotein-mediated cell fusion and infection by an antibody to CD4 domain 2 in combination with anti-gp120 antibodies.
... CD4 1 cells are in the same range ...the anti-CD4 and anti-gp120 antibodies may inactivate more complexes in combination than alone at the same concentra- ...surface-bound antibody is ... See full document
7
Common Themes of Antibody Maturation to Simian Immunodeficiency Virus, Simian-Human Immunodeficiency Virus, and Human Immunodeficiency Virus Type 1 Infections
... TX-disrupted virus (1 to 3 mg of total viral protein represents approx- imately 30 to 90 ng of envelope glycoprotein per ...or human serum was added to each well and incubated for 1 h at room ... See full document
8
Selective Interactions of Polyanions with Basic Surfaces on Human Immunodeficiency Virus Type 1 gp120
... The anti-CD4 mouse MAb Q4120 (from ...with gp120 for CD4 binding ...HIV-1 gp120-specific MAbs of human origin were used (their specificities are in parentheses): 21h (CD4 binding site ... See full document
13
Primary Virus Envelope Cross-Reactivity of the Broadening Neutralizing Antibody Response during Early Chronic Human Immunodeficiency Virus Type 1 Infection
... the human im- munodeficiency virus type 1 (HIV-1) envelope gene alter cel- lular host range and neutralization epitopes of the virus (3, 4, ...neutralizing anti- body ... See full document
6
Characterization of the Outer Domain of the gp120 Glycoprotein from Human Immunodeficiency Virus Type 1
... of human immunodeficiency vi- rus 1 (HIV-1) is expressed as a gp160 precursor, which is then proteolytically cleaved into two mature glycoproteins, gp120 and gp41, in the Golgi ... See full document
12
Structure of the Fab Fragment of F105, a Broadly Reactive Anti-Human Immunodeficiency Virus (HIV) Antibody That Recognizes the CD4 Binding Site of HIV Type 1 gp120
... with gp120 D-loop residues (orange oval, behind the plane of the ...of gp120 similar to that bound by b12, it is likely to tilt away from  15, shifting the light chain down and away from the D loop and ... See full document
10
Identification and Characterization of a Peptide That Specifically Binds the Human, Broadly Neutralizing Anti-Human Immunodeficiency Virus Type 1 Antibody b12
... the development of a prophylactic vaccine: to elicit Abs having neutralizing activities similar to those of the currently known, broadly neutralizing MAbs (b12, 2G12, and ...degree during natural infection; ... See full document
8
The Mannose-Dependent Epitope for Neutralizing Antibody 2G12 on Human Immunodeficiency Virus Type 1 Glycoprotein gp120
... of gp120 that form a mannose-rich structure which 2G12 rec- ...2G12-like anti- bodies might exist that recognize broadly similar glycan-depen- dent epitopes without necessarily competing for 2G12 binding to ... See full document
13
Human monoclonal antibody 2G12 defines a distinctive neutralization epitope on the gp120 glycoprotein of human immunodeficiency virus type 1.
... taining 1% Triton ...to gp120. Recombinant vaccinia virus-derived gp160/IIIB (a gift from Immuno AG) was coated onto microtiter plates at a concentration of 5 m ...of human MAbs 2G12 and 1B1 ... See full document
9
Immunization with a soluble CD4-gp120 complex preferentially induces neutralizing anti-human immunodeficiency virus type 1 antibodies directed to conformation-dependent epitopes of gp120.
... Conformational epitope on gpl20 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody.. Broadly neutralizing antibodie[r] ... See full document
9
Antibody Neutralization-Resistant Primary Isolates of Human Immunodeficiency Virus Type 1
... soluble gp120 and gp41 from resistant vi- ruses with ...tralizing antibody to the virion may occur, as has been de- scribed for the V2 (31) or V3 (18) loop and in vitro escape mutants of MAb b12 ...mutant ... See full document
5
Autologous and heterologous neutralizing antibody responses following initial seroconversion in human immunodeficiency virus type 1-infected individuals.
... after seroconversion. CD8 T-cell noncytolytic anti-HIV activity (25) and decreased plasma virus load were observed before detection of autologous neutralization, suggesting that NA are not ... See full document
8
Development of Broadly Neutralizing Antibodies and Their Mapping by Monomeric gp120 in Human Immunodeficiency Virus Type 1-Infected Humans and Simian-Human Immunodeficiency Virus SHIVSF162P3N-Infected Macaques
... of gp120 W479A ⫹ D368R ⫹ B cells showed only tier 1 (GB40_b1 to GB40_b9) or no (GB40_b10 to GB40_b13) neutralizing activity, indicating that this dual staining with gp120s was not specific enough to select ... See full document
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