[PDF] Top 20 Dicer is required for Sertoli cell function and survival
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Dicer is required for Sertoli cell function and survival
... of Sertoli cell death and faulty development may be a consequence of long-term stability of miRNAs such that their levels start to decrease only after a lag phase of several days following Dicer ... See full document
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MAPK1 is required for establishing the pattern of cell proliferation and for cell survival during lens development
... embryonic development with minor developmental defects in thymocyte and adipocyte differentiation (Bost et al., 2005; Pagès et al., 1999). Recent results from Mapk1 conditional deletion mice suggest that MAPK1 and MAPK3 ... See full document
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Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development
... for Dicer and Dicer-regulated pathways in controlling developmental timing and neuronal lineage specification, we generated a cortex-specific Dicer mutant in which Dicer is deleted before the ... See full document
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UPF2, a nonsense mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome
... Many genes are essential for early development and, as their inactivation leads to early embryonic lethality, this precludes further investigation of their functions in late embryonic and postnatal development. The cKO ... See full document
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Verteporfin blocks Clusterin which is required for survival of gastric cancer stem cell by modulating HSP90 function
... five-year survival rate is very low ...cancer cell in chemotherapy [19, 29, ...anti-apoptotic function of clusterin to sustain their ...in cell culture and in animal, it appears clusterin is a ... See full document
13
The pioneer factor Smed gata456 1 is required for gut cell differentiation and maintenance in planarians
... Smed-gata456-1 is expressed in neoblasts (S. Fig. 3A’) (Wagner et al., 2011). At 2 days of regeneration, Smed-gata456-1 was highly expressed in the tips of the regenerating gut, in one ante- rior and two posterior ... See full document
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<p>ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells</p>
... potential function of ELL2 in PC-3 and DU145, two AR-negative prostate cancer cell ...PCR. Cell growth was determined by BrdU, MTT and colony formation assays. Cell death was analyzed by ... See full document
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Sertoli cells control peritubular myoid cell fate and support adult Leydig cell development in the prepubertal testis
... is required for normal development of both PTMCs and ALCs (Clark et ...of cell adhesion molecules, whereas extracellular matrix components are apparently normal, and the fate of the PTMC in these animals is ... See full document
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Characterization of Drosophila mini-me, a Gene Required for Cell Proliferation and Survival
... , Figure 8, D–F; N agel and P reiss 1999), by both alleles. To determine whether Dpp or Notch signaling is affected in cells lacking mnm, we stained mnm null clones in the eye for pMad (target of Dpp signaling; W ... See full document
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The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity
... of cell survival and proliferation by Shh precedes via a non canonical pathway independent of Gli activity, our data suggest that this is not the ...is required for the survival of ... See full document
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RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche
... stem cell niche, we used a Cre recombinase-loxP conditional knockout strategy to disrupt Rbpj function in Sertoli cells before ...in Sertoli cells resulted in increases in the number of ... See full document
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HP1γ function is required for male germ cell survival and spermatogenesis
... wild-type testes were stained with HP1β-antibody. (b) A more detailed analysis of the HP1β staining showed that Sertoli cells (black arrowhead) were stained. HP1β did not stain meiotic chromosomes and was instead ... See full document
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Differential proteomics analysis of low- and high-grade of astrocytoma using iTRAQ quantification
... the cell proliferation, invasion, and angiogenesis-related pathways increase from low- to high-grade of ...inhibiting cell proliferation, in vitro migration/invasion in glioma ... See full document
13
Retiform Sertoli Leydig Cell Tumor of the Ovary
... Sertoli-Leydig cell tumor of the ovary is a kind of sex cord-stromal tumor, which oc- curs between teens and twenties with symptoms including abdominal pain and swel- ...“retiform Sertoli-Leydig ... See full document
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Ovarian Sertoli cell tumours: practical points
... ovarian Sertoli cell tumours like cord or trabecular, retiform, spindles, diffuse or alveolar ...cuboidal Sertoli-like cells, with moderate to abundant amounts of slightly eosinophilic cytoplasm, ... See full document
5
L’Inhibine B sérique, marqueur sensible de la production spermatique chez l’homme
... : Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction.. : High frequency of sub-optimal semen quality in an unselected population [r] ... See full document
15
Zika Virus Infects Human Sertoli Cells and Modulates the Integrity of the In Vitro Blood-Testis Barrier Model
... SC function in spermatogenesis and effects of environmental toxins on barrier integrity leading to male infertility (35, ...and cell types involved in the dissemination of the virus to developing spermatids ... See full document
17
Germ line differentiation factor Bag of Marbles is a regulator of hematopoietic progenitor maintenance during Drosophila hematopoiesis
... blood cell precursors and is downregulated during the differentiation of mature ...blood cell precursors coupled with an expansion of P1-positive plasmatocytes ... See full document
6
Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling
... in Sertoli cells, such as apoptosis, proliferation, polarity and the androgen/estrogen ...in Sertoli cell lysates from control and Gata4 cKO testes (Figure ...of Sertoli cell injury and ... See full document
16
Targeting autophagy in cancer management – strategies and developments
... Notes: mTOR is one of the most important regulators of autophagy. mTOR and other pathways including cAMP, LKB, AMPK, and PKA merge at mTORC1. AMPK inhibits mTORC1 by direct interaction or by indirect activation of the ... See full document
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