[PDF] Top 20 Dictyostelium discoideum: a model system for differentiation and patterning

... During Dictyostelium development cell type differentiation and gene expression patterns are tightly controlled. Many mutants display abnormalities on these aspects that can be studied by following the ... See full document

... this Dictyostelium signaling system appears to be a very early example of a mechanism that is widespread in more recently evolved ...neuronal differentiation (8), rather as I am proposing that it ... See full document

... single model organism, Dictyostelium ...motility, differentiation and patterning, the versatility of D. discoideum has allowed in recent years the expansion of our knowledge to other ... See full document

... Because of its unusual mode of development, the cellular slime mould D. discoideum is ideal for probing the links between single cell physiology and multicellular patterning. The multicellular stage of D. ... See full document

... used Dictyostelium as a model organism to study the effects of ...in Dictyostelium to date, puromycin-sensitive aminopeptidase A and B (PsaA and ...of Dictyostelium, and its expression is ... See full document

... mould Dictyostelium discoideum and it was owing to use of D. discoideum as a model system that it was first proved that FDPS is the target for the drugs ...(Dictyostelium ... See full document

... The studies described above demonstrate complex remodelling of endosomes throughout their transit through the cell. Multiple mechanisms are employed to retrieve and deliver both soluble and transmembrane components at ... See full document

... A cell mass confined between two glass plates was prepared as previously described (Sawada et al., 1998). Cells were pelleted by centrifugation and the supernatant was removed. Cells were carefully collected from the ... See full document

... cellular differentiation of ...in Dictyostelium genomic DNA, but the recent sequencing of the Dictyostelium genome revealed a candidate DNA methyltransferase gene ...of Dictyostelium genomic ... See full document

... D. discoideum, naringenin reduces cell growth, blocks cellular movement and causes cells to lose shape following acute (30 min) exposure (Waheed et ...D. discoideum mutant library was screened to identify ... See full document

... the model Dictyostelium discoideum, the fruiting bodies consist of a mass of spores that is held aloft on a column of stalk cells, and three additional cell types that form a basal disc to support ... See full document

... D. discoideum, membrane dam- ages caused by Mycobacterium marinum activate an autophagic defence response reflected by an up-regulation of autophagy genes, stimulation of autophagosome formation and recruitment to ... See full document

... terminal differentiation into ...The model that can account for size-invariant proportioning can also account for regulation following perturbation of the cell type proportions ...prespore ... See full document

... the Dictyostelium discoideum gpbB gene as the Dictyostelium RACK1 ...D. discoideum as developmental and other defects were not rescued in G β null mutants overexpressing ... See full document

... six Dictyostelium chromosomes have not yet been assembled, ongoing efforts by the Dictyostelium genome sequencing consortium have generated more than eightfold coverage of protein coding regions, and more ... See full document

... My Dictyostelium cD N A library was now ready to be transformed into a strain o f cyclin- deficient S. cerevisiae, in order to attempt the isolation o f novel cyclins by complementation. A tight selection scheme ... See full document

... Fig. 2. Phylogeny of Dictyostelia . All known species of social amoebas can be subdivided into four major groups based on phylogenetic analysis of their small subunit ribosomal RNA sequences (Schaap et al., 2006). Group ... See full document

... Exponentially growing amoebae were labeled with SYTO-11 and sorted on the basis of relative DNA content into two sub- populations. The first consisted of amoebae from channels 75-250 (window x2, S phase) while the second ... See full document

... In animals, contests and fights are often won by the largest individuals or those in the best condition. Consistent with this, D. discoideum cells fed glucose are more likely to become spores over those starved of ... See full document

... - pression from the roco4 promoter. Furthermore, promoter ac- tivity analysis shows that the protein is expressed mainly in prestalk cells. In roco4-null cells, the roco4 promoter shows normal spatial and nearly normal ... See full document