[PDF] Top 20 Differences in the Regulatory and Functional Effects of the Us3 Protein Kinase Activities of Herpes Simplex Virus 1 and 2
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Differences in the Regulatory and Functional Effects of the Us3 Protein Kinase Activities of Herpes Simplex Virus 1 and 2
... HSV-1 Us3 autophosphorylation site (Ser-147) in upregulation of its own kinase activity, viral replication, and HSV-1 pathogenesis, we noticed that the HSV-2 Us3 amino acid ... See full document
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Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene
... Us3 protein kinases encoded by herpes simplex virus 1 (HSV-1) and 2 (HSV-2) play important roles in viral replication and ...type-specific differences ... See full document
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The Interaction of Herpes Simplex Virus 1 Regulatory Protein ICP22 with the cdc25C Phosphatase Is Enabled In Vitro by Viral Protein Kinases US3 and UL13
... a kinase reaction. cdc25C was immuno- precipitated from lysates of HEp-2 cells harvested 18 h after infection with HSV-1(F) or mock ...H1 kinase buffer containing [ ␥ - 32 P]ATP for 15 min ... See full document
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Analysis of the Phosphorylation Sites of Herpes Simplex Virus Type 1 Regulatory Protein ICP27
... Table 1, or with wild-type ICP27 or pGEM-1 vector ...deletion virus, ...line 2-2 (48) (Table 1). In this assay, pGEM-1 served as a nega- tive control, and its ability to ... See full document
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Mapping of Key Functions of the Herpes Simplex Virus 1 US3 Protein Kinase: the US3 Protein Can Form Functional Heteromultimeric Structures Derived from Overlapping Truncated Polypeptides
... titers of the baculoviruses were determined on Sf9 cells grown in six-well plates. Preparation of cell lysates, electrophoretic separation of proteins, and immu- noblotting. Cell cultures transduced with baculoviruses ... See full document
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CK2 Protein Kinase Is Stimulated and Redistributed by Functional Herpes Simplex Virus ICP27 Protein
... multifunctional herpes simplex virus type 1 (HSV-1) protein, interacts with CK2 and with heterogeneous ribonucleoprotein K (hnRNP ...ubiquitous protein kinase, and ... See full document
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The US3 Protein Kinase Blocks Apoptosis Induced by the d120 Mutant of Herpes Simplex Virus 1 at a Premitochondrial Stage
... cytopathic effects of a mutant lacking ICP0 in addition to other ␣ proteins have been reported to be grossly reduced ...mutant virus- infected cells (9). The protein accumulates initially in nuclei, ... See full document
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Regulation of the Catalytic Activity of Herpes Simplex Virus 1 Protein Kinase Us3 by Autophosphorylation and Its Role in Pathogenesis
... of Us3 antiapoptotic ...the Us3 null mutant virus R7041 ...The differences in caspase 3/7 activity FIG. 9. Effects of the Us3-S147A and Us3-K220M mutations on virus ... See full document
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Effects of Phosphorylation of Herpes Simplex Virus 1 Envelope Glycoprotein B by Us3 Kinase In Vivo and In Vitro
... The herpes simplex virus 1 (HSV-1) Us3 gene encodes a serine/threonine protein kinase with an amino acid sequence that is conserved in the subfamily ... See full document
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Suppression of Extracellular Signal-Regulated Kinase Activity in Herpes Simplex Virus 1-Infected Cells by the Us3 Protein Kinase
... by Us3 either stimulate virus replication or do not negatively impact the viral replication ...inhibit virus replication), may not be limited to virus-encoded kinases and may also include ... See full document
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Phosphorylation of a Herpes Simplex Virus 1 dUTPase by a Viral Protein Kinase, Us3, Dictates Viral Pathogenicity in the Central Nervous System but Not at the Periphery
... that Us3 phosphorylated vdUTPase at serine 187 (Ser-187) in infected cells ...34). Us3 phosphorylation of vdUTPase at Ser-187 appeared to regulate op- timal activity of vdUTPase in infected cells, based on ... See full document
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Herpes Simplex Virus 1-Encoded Protein Kinase UL13 Phosphorylates Viral Us3 Protein Kinase and Regulates Nuclear Localization of Viral Envelopment Factors UL34 and UL31
... factor 1 ␦ (EF-1 ␦ ), casein kinase II  subunit, and RNA polymerase II have been reported to be putative substrates for UL13 (4, 10, 20, 29, 32, 37, 44, 51, 57, ...cellular protein ... See full document
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Role of the Herpes Simplex Virus 1 Us3 Kinase Phosphorylation Site and Endocytosis Motifs in the Intracellular Transport and Neurovirulence of Envelope Glycoprotein B
... dorabies virus (PRV), human cytomegalovirus (HCMV), and varicella-zoster virus (VZV) (4, 13, 18, ...the effects of these motifs on the regulation of gB intracellular transport, proper localization ... See full document
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Herpes Simplex Virus 1 Protein Kinase Us3 Phosphorylates Viral Envelope Glycoprotein B and Regulates Its Expression on the Cell Surface
... viral protein kinase acts in infected cells, the kinase’s physiological substrate(s) and its phosphorylation site(s) must be ...mutant virus lacking protein kinase activity also is ... See full document
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Herpes Simplex Virus 1 Serine/Threonine Kinase US3 Hyperphosphorylates IRF3 and Inhibits Beta Interferon Production
... that US3 kinases from HSV-1 and other alphaherpesviruses and pseudorabies virus (PRV) show a similar minimal consensus phosphorylation sequence, which was characterized as (R)n-X-(S/T)-Z-Z (n ⱖ ... See full document
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Herpes Simplex Virus 1 and 2
... of herpes simplex infection depends on the age and immune status of the host, the anatomic site of involvement, and the antigenic virus ...Primary herpes simplex virus ... See full document
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Phosphorylation of the UL31 Protein of Herpes Simplex Virus 1 by the US3-Encoded Kinase Regulates Localization of the Nuclear Envelopment Complex and Egress of Nucleocapsids
... The cells were then dehydrated at 4°C using a graduated series of ethanol concentrations (20%, 50%, 70%, and 100%), a subsequent acetone-ethanol mixture (1:1), and, finally, 100% acetone. This was followed ... See full document
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Herpes simplex virus alpha protein ICP27 possesses separable positive and negative regulatory activities.
... 3399 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The HSV-1 alpha immediate-early protein ICP27 expressed in transfected cells can activate the expression of certain[r] ... See full document
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Functional analysis of the herpes simplex virus UL42 protein.
... This altered polypeptide also failed to increase the length of DNA product synthesized by Pol, and the mutant gene could not complement the growth of a UL42 null virus, indicating that t[r] ... See full document
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US3 of Herpes Simplex Virus Type 1 Encodes a Promiscuous Protein Kinase That Phosphorylates and Alters Localization of Lamin A/C in Infected Cells
... fluorescent protein (eGFP)-lamin A/C-expressing cell line was made by transfection of DNA containing a cDNA of LmnA fused to eGFP-C1 and encoding neomycin resistance (a kind gift from ... See full document
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