[PDF] Top 20 Differential Pathogenesis of Primary CCR5-Using Human Immunodeficiency Virus Type 1 Isolates in Ex Vivo Human Lymphoid Tissue
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Differential Pathogenesis of Primary CCR5-Using Human Immunodeficiency Virus Type 1 Isolates in Ex Vivo Human Lymphoid Tissue
... viral isolates, all of which were of the R5 ...tial pathogenesis of these R5 isolates in tissues are, we provide here the first published evidence that the evolution of these factors is consistent ... See full document
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Cytopathicity of Human Immunodeficiency Virus Type 2 (HIV-2) in Human Lymphoid Tissue Is Coreceptor Dependent and Comparable to That of HIV-1
... of human lymphoid tissue ex vivo. Human tonsil and adenoid tissue removed during routine tonsillectomy (provided by San Francisco General Hos- pital, Kaiser-San Francisco, ... See full document
7
Human Immunodeficiency Virus Type 1 Variants Resistant to First- and Second-Version Fusion Inhibitors and Cytopathic in Ex Vivo Human Lymphoid Tissue
... the virus for easier development of resistance to second-iteration fusion inhibitors targeting the ...by using the standard passage ...obtained using the molecular NL4-3 clone are also valid for the ... See full document
10
CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4+ T-Cell Depletion in Human Lymphoid Tissue Ex Vivo
... and tissue cytoarchitecture found in vivo (10, ...nef-deleted virus [Fig. 1; ...(Fig. 1; ...inactive primary LTNP4-91B1 Nef, resulting in some gain of function in down-modulation ... See full document
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Pathogenesis of Primary R5 Human Immunodeficiency Virus Type 1 Clones in SCID-hu Mice
... Human immunodeficiency virus type 1 (HIV-1) enters cells by binding to the cell surface glycoprotein CD4 and then to one of several seven-transmembrane trimeric GTP-binding ... See full document
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Vpr and Vpu Are Important for Efficient Human Immunodeficiency Virus Type 1 Replication and CD4+ T-Cell Depletion in Human Lymphoid Tissue Ex Vivo
... Human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus (SIV) have several genes that are not absolutely required for viral spread in cell ... See full document
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Proline 35 of Human Immunodeficiency Virus Type 1 (HIV-1) Vpr Regulates the Integrity of the N-Terminal Helix and the Incorporation of Vpr into Virus Particles and Supports the Replication of R5-Tropic HIV-1 in Human Lymphoid Tissue Ex Vivo
... in virus replication and pathogenesis in vivo (6, 12, ...into virus particles via an interaction with the p6 domain of the Gag precursor Pr55 involving residues 32 to 46, which comprise the ... See full document
5
Biological Signature Characteristics of Primary Isolates from Human Immunodeficiency Virus Type 1 Group O in Ex Vivo Human Tonsil Histocultures
... including primary isolates 2005 (group M; X4) and 2901 (group O; X4), severely depressed the CD4/CD8 ratio ...R5 primary isolates of group O, isolates 2549 and 13740, displayed a high ... See full document
10
Comparing the Ex Vivo Fitness of CCR5-Tropic Human Immunodeficiency Virus Type 1 Isolates of Subtypes B and C
... heterogeneous primary HIV-1 isolates (6, 43, ...complete virus (33, 38, 46, 49). Hence, this study has investigated the ex vivo fitness differences between primary ... See full document
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Viral Interactions in Human Lymphoid Tissue: Human Herpesvirus 7 Suppresses the Replication of CCR5-Tropic Human Immunodeficiency Virus Type 1 via CD4 Modulation
... and ex vivo-infected blocks of human lymphoid tissue 12 days ...total tissue weight at day 12 for tissue blocks from each ...in ex vivo infected human ... See full document
10
Impact on Genetic Networks in Human Macrophages by a CCR5 Strain of Human Immunodeficiency Virus Type 1
... by virus clearly distinguished between HIV-1 and mock-treated cultures even though ...with virus were infected by day 2 and only 10% were infected by day ...macrophages ex vivo ... See full document
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Association of Nef with p21-Activated Kinase 2 Is Dispensable for Efficient Human Immunodeficiency Virus Type 1 Replication and Cytopathicity in Ex Vivo-Infected Human Lymphoid Tissue
... the virus- producing cell enhances virion infectivity at an early step of the viral replication cycle (12, 42, 65) and might require dynamin 2 ...in primary lymphocyte culture and ex vivo- ... See full document
10
Human Immunodeficiency Virus Type 1 Induces Apoptosis in CD4+ but Not in CD8+ T Cells in Ex Vivo-Infected Human Lymphoid Tissue
... (Caltag), CCR5-APC, and CXCR4-APC ...permeabilized using Cytofix-Cytoperm (PharMingen) ac- cording to the manufacturer’s instructions and stained for the mitochondrial antigen 7A6 using monoclonal ... See full document
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CCR5- and CXCR4-Utilizing Strains of Human Immunodeficiency Virus Type 1 Exhibit Differential Tropism and Pathogenesis In Vivo
... Paraformaldehyde-fixed tissue was embedded in par- affin, and 5-mm sections were transferred to glass microscope ...Dako), human CD68 (clone KP1; Dako), or human S100 (clone 15E2E2; Biogenex) in ... See full document
10
Tissue-Resident Macrophages Are Productively Infected Ex Vivo by Primary X4 Isolates of Human Immunodeficiency Virus Type 1
... Macrophages in infected tonsils are CD3 negative. To ad- dress whether the colocalization of p24 and CD68 could, in part, be due to phagocytosis of infected T cells, we performed costaining for CD68 and the T-cell marker ... See full document
7
CpG Oligodeoxynucleotides Block Human Immunodeficiency Virus Type 1 Replication in Human Lymphoid Tissue Infected Ex Vivo
... examined virus-cell membrane fusion, we cannot exclude the possibility that CpG2216 and CpG10 act on virus entry after receptor binding but before virus-cell mem- brane fusion, as reported for the ... See full document
11
Interactions between Human Immunodeficiency Virus Type 1 and Vaccinia Virus in Human Lymphoid Tissue Ex Vivo
... infected tissue blocks on day 12 after ...for ex- pression of lymphocyte ...CD62L, CCR5, and CXCR4, using anti-CD3–phycoerythrin (PE)-Cy7 or PE-Alexa 610, ...vaccinia virus antigens ... See full document
7
Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1
... by human immuno- deficiency virus type 1 (HIV-1) requires collaboration between CD4 and coreceptors on surfaces of susceptible cells (2, 4, 15, 19, 21, 22, 26, ...(M-tropic) ... See full document
10
Variable Sensitivity of CCR5-Tropic Human Immunodeficiency Virus Type 1 Isolates to Inhibition by RANTES Analogs
... HIV-1 isolates. Unlike antiretroviral drugs, which inhibit more conserved HIV-1 enzymes, CCR5 agonists such as AOP- RANTES target an interaction between the highly variable HIV-1 ... See full document
9
Persistent CCR5 Utilization and Enhanced Macrophage Tropism by Primary Blood Human Immunodeficiency Virus Type 1 Isolates from Advanced Stages of Disease and Comparison to Tissue-Derived Isolates
... blood isolates collected from 27 individuals at different stages of human immunodeficiency virus type 1 (HIV-1) disease and tissue derived isolates from 10 ... See full document
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