[PDF] Top 20 DNA methylation is associated with lung function in never smokers
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DNA methylation is associated with lung function in never smokers
... differential DNA methyla- tion at the majority of the CpG-sites in our study occurs without exposure to smoking, the question arises why this differential DNA methylation is ...in DNA methyla- ... See full document
11
Lung function discordance in monozygotic twins and associated differences in blood DNA methylation
... identified DNA methylation at several CpG sites associated with intra-pair difference in level of lung function for the different ...significant associated finding for the level ... See full document
13
Dietary patterns are associated with lung function among Spanish smokers without respiratory disease
... positively associated with increased COPD risk, even after adjust- ing for age and total energy intake [19, ...is associated with better lung function, especially in men who smoke ...preserve ... See full document
12
Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers
... tobacco smokers and comprehensively genotyped them for ADAM33 vari- ...were associated with ...also associated with lung function measure- ...it associated with lung ... See full document
9
Changes of DNA methylation are associated with changes in lung function during adolescence
... DNA methylation (DNA-M), as a potential marker of past exposure or significant changes in life such as pubertal onset, is an epigenetic mechanism and has been shown to play an important role in human ... See full document
14
Understanding the contribution of native tracheobronchial structure to lung function: CT assessment of airway morphology in never smokers
... and lung function in never smoking nor- mals ...in smokers with chronic obstructive pulmonary disease (COPD) ...106 never smoking normal subjects enrolled in the COPDGene ...with ... See full document
9
Epigenomic analysis of lung adenocarcinoma reveals novel DNA methylation patterns associated with smoking
... of lung cancer, on DNA methylation by comparing the genome-wide DNA methylation patterns between lung adenocarcinoma samples from six smokers and six ...smoking-induced ... See full document
9
From blood to lung tissue: effect of cigarette smoke on DNA methylation and lung function
... actual lung tissue, we have to consider some limitations of our ...were associated with lung function levels rather than implying biological ...that DNA methylation levels at ... See full document
9
RARβ2 hypermethylation is associated with poor recurrence-free survival in never-smokers with adenocarcinoma of the lung
... Before DNA extraction, we performed hematoxylin-eosin staining to locate the tumor areas and microdissected areas contain- ing at least 75% neoplastic ...genomic DNA was purified using the DNeasy Blood ... See full document
10
Alu and LINE-1 methylation and lung function in the normative ageing study
... with lung function or change in effect estimate criterion of >10% after addition to the model and included age, height, race, pack-years of cig- arette smoking, smoking status (dichotomised as current vs ... See full document
8
Smoking-associated DNA methylation markers predict lung cancer incidence
... the lung tissue of smokers ...locus associated with smoking ...F2RL3 methylation is a strong predictor for both LC inci- dence and mortality [15], and smoking-induced hypomethy- lation at ... See full document
12
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies
... reduced lung function could be the cause of the altered DNA methyla- tion profiles, rather than the ...of smokers and pack-years [23, 25, 26], one study did not provide information on smoking ... See full document
10
Childhood asthma is associated with COPD and known asthma variants in COPDGene: a genome-wide association study
... adult smokers from the COPDGene Study, to see if they share similar phenotypes and genotypes with those seen in asthmatic subjects from prior studies, including published GWAS [2, 3, ...be associated with ... See full document
11
DNA methylation profiling in peripheral lung tissues of smokers and patients with COPD
... genes/pathways associated with possible differential DNA methylation in smokers and patients with COPD using the Infinium Human- Methylation450 ...genome-wide DNA methylation and ... See full document
18
DNA methylation in lung cells is associated with asthma endotypes and genetic risk
... Residual methylation β values after regression were used for all analyses in which gender, ethnicity, and age were included as covariates in the model to identify ...significantly associated with principal ... See full document
16
Altered lung biology of healthy never smokers following acute inhalation of E-cigarettes
... disordered lung biology observed in the present study, there is literature demonstrating clinical abnormalities associated with acute inhalation of EC, in- cluding cough, decreased fractional exhaled nitric ... See full document
10
Increased methylation of lung cancer-associated genes in sputum DNA of former smokers with chronic mucous hypersecretion
... between methylation and CMH was markedly stronger in males than in females (Table ...between methylation and CMH in ...between methylation and CMH was also stronger in former than in current ... See full document
9
TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer
... TMEM196 methylation correlated with loss of protein expression in chemical-induced rat lung pathologic lesions and human lung cancer tissues and cell ...primary lung tumours and found to be ... See full document
15
DNA methylation in the APOE genomic region is associated with cognitive function in African Americans
... been associated with AD or its underlying pathology in the ...decreased methylation was ob- served in the CpG island (CGI) nested within the fourth exon of APOE in brain tissue from AD cases compared to ... See full document
13
Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients
... be associated with hepatic ...cigarette smokers [28], but decreased in the ELF during COPD exacerbations ...thereby function as a potential reservoir of GSH during oxidative ... See full document
9
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