[PDF] Top 20 Drosophila Damaged DNA-Binding Protein 1 Is an Essential Factor for Development
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Drosophila Damaged DNA-Binding Protein 1 Is an Essential Factor for Development
... Figure 2.—(A) Knock down of the D-DDB1 level by expression of the 650-bp D-DDB1 double-strand RNAs in living flies [UAS-D-DDB1(650)-dsRNA/⫹; Act5C-GAL4/⫹] caused melanotic tumors and al- most all flies died in the larval ... See full document
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CbfA, the C-Module DNA-Binding Factor, Plays an Essential Role in the Initiation of Dictyostelium discoideum Development
... Genomewide DNA microarray analysis of expression pro- files is a powerful tool that extends our knowledge of the complex gene networks that regulate ...host-encoded protein that binds specifically to a ... See full document
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Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants.
... GAL4 DNA-binding domain (GAL4BD) in the yeast strain Y190 ...full-length protein, the assays were performed with protein domains previously reported to interact with HBx: RPB5 (amino acids 47 ... See full document
6
The human foamy virus Bel-1 transcription factor is a sequence-specific DNA binding protein.
... several DNA response elements for the essential Bel-1 regulatory protein of HFV have been mutationally de- fined, it has remained unclear whether Bel-1 is targeted to these sites by ... See full document
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Regulation and Dynamic Behavior of the Heat Shock Transcription Factor Hsf-1 in C. Elegans
... transcription factor (HSF) is a conserved regulator of heat shock- inducible gene ...as development, aging, and immunity have been defined in great part through studies of the single ...fusion ... See full document
209
Turnover of Hepatitis B Virus X Protein Is Regulated by Damaged DNA-Binding Complex
... tion factor Crz1p induced by the response regulator transcrip- tion factor Skn7p (46) provide related examples of specific stabilization effects mediated by physical ...stabilized protein might ... See full document
7
A unique loop in T7 DNA polymerase mediates the binding of helicase-primase, DNA binding protein, and processivity factor
... the DNA binding crevice ...(Fig. 1). The tight binding of the hexam- eric helicase to ssDNA enhances the low affinity of the primase for DNA ...is essential for the coordination ... See full document
7
Azadiradione ameliorates polyglutamine expansion disease in Drosophila by potentiating DNA binding activity of heat shock factor 1
... the protein under the reaction ...HSF1 protein in the presence of ...substrate binding pocket of HSP90 chaperone ...unrelated protein lysozyme in the same concentration range (Figure ...of ... See full document
16
An essential role for the RNA binding protein Smaug during the Drosophila maternal to zygotic transition
... the DNA replication checkpoint and initiate high level expression of the vast majority of genes that are transcribed during the final stages of the ...is essential for blastoderm cellularization, which ... See full document
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Detection of AML1/ETO Fusions Transcript in Acute Myeloid Leukemia in Sudanese Patients
... N-terminal DNA-binding domain of AML1, a transcription factor essential for definitive hematopoiesis, and almost all of ETO, a protein thought to function as a corepressor for a variety ... See full document
10
Damaged DNA-binding protein 2 (DDB2) protects against UV irradiation in human cells and Drosophila
... induce DNA repair in irradiated cells. Damaged DNA-binding (DDB) proteins, which mediate a key process in nucleotide excision repair after UV damage, represent a complex consisting of the two ... See full document
14
Composition and Assembly of STAT-Targeting Ubiquitin Ligase Complexes: Paramyxovirus V Protein Carboxyl Terminus Is an Oligomerization Domain
... cullins 1 (Roc1, also known as Rbx1) (reviewed in reference ...domain-containing protein that is thought to recruit the E2 ubiquitin-conjugating enzyme to facilitate ubiquitin transfer onto substrates (13, ... See full document
10
Imprinting of X-chromosome inactivation and functional studies of the regulation of Xist promoter activity in preimplantation embryos and transgenic mice
... The spreading process has been probed by using transgenes. Some X-linked transgenes (transgene integrated on the X chromosome) have been shown to be inactivated on the inactive X chromosome (Collick et a l, 1988; Dandolo ... See full document
379
The CRE-Binding Protein dCREB-A Is Required for Drosophila Embryonic Development
... Another CRE- binding protein, CREMa, may downregulate CAMP- stimulated CREB activity by forming heterodimers with CREB (FOULKES et al. Ultimately, we would like to unde[r] ... See full document
12
Insulin-like growth factor binding protein-3 is required for the regulation of rat oval cell proliferation and differentiation in the 2AAF/PHX model
... IGFBP-3 protein (Figure 8A) as compared to controls (Figure 8C and Supplemental Figure ...IGFBP-3 protein was administered to animals in combination with IGFBP-3 siRNA, we detected an increase in IGFBP-3 ... See full document
20
Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage
... for damaged-DNA. It binds to UV-damaged DNA, cisplatin-modified DNA, as well as single-stranded DNA with high affinities ...binds damaged-DNA in conjunction with ... See full document
5
CCAAT/enhancer binding protein β promotes receptor activator of nuclear factor kappa B ligand (RANKL) expression and osteoclast formation in the synovium in rheumatoid arthritis
... -minimum essential medium; AP-1: activator protein-1; ATF-4: activation transcription factor 4; bp: base pairs; C/EBP: CCAAT/enhancer binding protein; ChIP: chromatin ... See full document
11
Monoclonal Antibodies against the Minimal DNA-Binding Domain in the Carboxyl-Terminal Region of Human Immunodeficiency Virus Type 1 Integrase
... type 1 (HIV-1) has revealed that the C-terminal region (amino acids [aa] 160 to 288) contains nonspecific DNA-bind- ing activity (18, 31, 40, 42), which is mapped to aa 220 to 270 (the minimum ... See full document
6
The 60-Residue C-Terminal Region of the Single-Stranded DNA Binding Protein of Herpes Simplex Virus Type 1 Is Required for Cooperative DNA Binding
... the DNA strand was reported for the T4 gene 32 protein ...the protein chain, around which the ssDNA is presumably wrapped, has been shown by crystallography ...replication protein A, the ... See full document
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Association of JC Virus Large T Antigen with Myelin Basic Protein Transcription Factor (MEF-1/Purα) in Hypomyelinated Brains of Mice Transgenically Expressing T Antigen
... Examination of hippocampal neurons by immunogold elec- tron microscopy demonstrated T antigen in association with strands of diffuse chromatin just external to the nucleolus (Fig. 3E and F). In addition, several ... See full document
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