[PDF] Top 20 Dynamic stem cell heterogeneity
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Dynamic stem cell heterogeneity
... 1990), stem cell identity has been localized to a permanent and discrete region of the hair follicle known as the bulge ...dormant stem cells residing in the bulge region sporadically enter into the ... See full document
11
Modeling the clonal heterogeneity of stem cells
... of stem cells depends on expansion, purifica- tion and differentiation of cells of specific types required for different clinical ...purposes. Stem cells are defined by the capacity to either self-renew or ... See full document
27
CD24 expression and stem-associated features define tumor cell heterogeneity and tumorigenic capacities in a model of carcinogenesis
... full-blown stem- ness is not indispensable for tumorigenesis, although some stem-like cell attributes may be needed, depending on the cell context and/or the stage of tumor ...of cell ... See full document
18
Stat5-deficient hematopoiesis is permissive for Myc-induced B-cell leukemogenesis
... hematopoietic stem/progenitor subsets to assess the impact of Stat5 on gene expression regulating HSC heterogeneity and early differentiation ...other cell types, since Slamf1 is a self-ligand ... See full document
12
Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity
... Palbociclib (PD-0332991; from Pfizer) was first approved by the FDA on February 3, 2015 as the first- line treatment for advanced post-menopausal ER+, HER2-negative breast cancer, in combination with letrozole [30]. It ... See full document
18
Heterogeneity of lymphocyte subpopulations in severe combined immunodeficiency Evidence against a stem cell defect
... helper cell defect or that his T cells were unable to produce soluble factors necessary for B cell ...for heterogeneity among patients with the clinical syndrome of severe combined ... See full document
8
Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells
... complex stem cell populations, such as hiPSCs. Quantitative single cell gene expression profiling of hESCs and comparison of hiPSCs to this reference standard are the initial steps toward achieving ... See full document
6
Understanding breast cancer stem cell heterogeneity: time to move on to a new research paradigm
... and stem cells has been widely and continuously analyzed, the heterogeneity in BC is still not completely un- derstood, which represents a major obstacle to effective cancer treatment and personalized ... See full document
5
RNA-silencing nanoprobes for effective activation and dynamic imaging of neural stem cell differentiation
... Inspired by the controlled release of siSOX9, we further tested the intracellular activity of cvNCs in NSCs by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot assays. As shown in Figure 2A, ... See full document
10
Differentiation Induces Dynamic Alterations in Mesenchymal Stem Cell Nuclear Architecture and Mechanotransduction
... Mesenchymal stem cells (MSCs) are a clinically appealing cell source for tissue engineering due to their multi-potentiality and ease of harvest (Pittenger et ...2010), cell shape (McBeath et ... See full document
321
The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy
... the dynamic fate of implanted allogeneic ASCs, includ- ing being eliminated by recipients, being maintained in the stem cell state, or differentiating into various cell types? It will be ... See full document
7
The heterogeneity of cancer stem-like cells at the invasive front
... Cancer stem-like cells exhibit the multi-functional roles to survive and persist for a long period in the minimal residual disease after the conventional anti-cancer ...Cancer stem-like cells of solid ... See full document
5
A dynamic population of stromal cells contributes to the follicle stem cell niche in the Drosophila ovary
... only cell types known to express Hh and Wg in the germarium are two somatic cell types, the cap cells and terminal filament cells (Forbes et ...several cell diameters away from the ...to stem ... See full document
9
Multipotent (adult) and pluripotent stem cells for heart regeneration: what are the pros and cons?
... BM-derived stem cells are able to trans-differentiate into various cell types, including neurons, hepatocytes, skeletal muscles and cardiomyocytes under appropriate culture conditions ...of ... See full document
12
Limited utility of tissue micro arrays in detecting intra tumoral heterogeneity in stem cell characteristics and tumor progression markers in breast cancer
... Previous studies about the predictive value of CD44 and CD24 have showed controversial results. In 2003, a CD44+/CD24− phenotype was first identified as a highly tumorigenic subpopulation of tumor cells with ... See full document
16
Multiple cell and population level interactions with mouse embryonic stem cell heterogeneity
... facilitate cell tracking, cells were stably transformed with a plasmid expressing H2B-mRFP from a PGK ...complete cell generations owing to increased cycle duration and ... See full document
10
miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/β-Catenin Axis
... cancer cell lines SUM149 (Basal subtype) and T47D (Luminal subtype) with specific miR-200c/141 inhibitors or scramble controls and examined the effects on the cell ...the cell proliferation of both ... See full document
13
Heterogeneity of the Level of Activity of Lgr5+ Intestinal Stem Cells
... CSCs heterogeneity has been demonstrated for breast and colorectal cancers (53, ...that stem cell markers Lgr5 and Ascl2 are enriched in Wnt high population whereas differentiation markers Muc2 and ... See full document
9
Feasibility study of using high-throughput drug sensitivity testing to target recurrent glioblastoma stem cells for individualized treatment
... Intratumoral heterogeneity is a major challenge when applying targeted treatment strategies ...passage cell cultures for DSRT and con- firmed the tumorigenicity of tumor cells by orthotopi- cally ... See full document
15
Endogenous molecular network reveals two mechanisms of heterogeneity within gastric cancer
... the heterogeneity of GC via the endogenous molecular ...nonlinear dynamic system, and the modeling results are compared with experimental ...exhibited cell cycle arrest and differentiated phenotype, ... See full document
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