[PDF] Top 20 The effect of multiple genetic variants in predicting the risk of type 2 diabetes

... unrelated diabetes cases from the 252 diabetes families ...families. Diabetes cases with age of diabetes onset less than 40 years were excluded from the study to eliminate patients with ... See full document

... 300 mg/24 hrs or 30 mg/g creatinine on a et al., 2014), is an early marker of diabetic nephropathy in type 2 diabetes. Nitric oxide (NO) is produced by the action of endothelial nitric oxide synthase ... See full document

... disease risk through b-cell dysfunction and insulin ...increased risk of type 2 ...neonatal diabetes and congenital hyperthyroidism [16], and the rs7020673 SNP within the gene is ... See full document

... , Durda K, Hsiung CN, Wu PE, Yu JC, Ashworth A, Jones M, Tessier DC, Gonzalez-Neira A, Pita G, Alonso MR, Vincent D, Bacot F, Ambrosone CB, Bandera EV, John EM, Chen GK, Hu JJ, Rodriguez-Gil JL, Bernstein L, Press MF, ... See full document

... common variants (rs1884613 and rs1884614) cannot be recognized as the T2DM and related complications susceptible risk factors in a group of Iranian ...gene variants with T2DM risk can be ... See full document

... Chinese risk score, which performed the best among all the fi rst-level classi fi ers according to the AUC and Youden ...9 risk scores that were established in previous studies, as listed in Table S3 ... See full document

... T2D risk factors and a GRS of GWAS-identified T2D ...as risk factors due to low degree of interaction with other factors, such as ...new genetic loci interacting with dietary factors [54, 55], ... See full document

... and risk factors were evaluated using computing ORs and its 95% CIs from multivariate logistic regression analysis, adjusted for age, body mass index (BMI), age at menarche and menopause, menopausal status, number ... See full document

... the genetic contri- bution of multiple ...penetrant risk muta- tions will be important starting ...of multiple risk variants, taking a small number of variants per assay, ... See full document

... decades, genetic studies, including genome-wide association studies (GWASs) and candidate gene strategies, have identified many susceptibility genes involved in the increased risk of T2D and GDM [6, ...the ... See full document

... the effect of ...a multiple sequence alignment, from which quantitative conservation information (a probability) is ...wild type sequence and a low prob- ability for the mutant sequence suggest that ... See full document

... low- risk variants would have the potential to identify a subgroup of individuals at increased risk for developing ...the effect of combined analysis of multiple genetic ... See full document

... genotype variants on retinopathy in patients with ...the risk of nephropathy in the patients with different CYP2C9 alleles, based on the marked increase in microalbuminuria and the decrease observed in the ... See full document

... adult-onset diabetes (so called type 2 diabetes) and its complications was fi rst brought up by Williamson et al in 1993 1 and has since garnered increasing attention in the fi eld of ... See full document

... shares multiple signaling pathways likehyperinsulinemia, glucotoxicity and inflammation in type 2 Diabetes Mellitus (DM) leads to several micro and macrovascular ...of diabetes related ... See full document

... significant effect on glucagon levels. No significant effect was observed on glucose levels during the IVGTT, but there was a dose-dependent increase in the glucose disappearance ... See full document

... independent risk factor for death in insulin-treated intensive care unit patients; the authors speculated that the associated hypoglycemia might have eliminated a significant mortality benefit in the intensive ... See full document

... in diabetes would offer extended ...patients’ diabetes therapy either in consultation with their primary health provider or independently, which has occurred in some jurisdictions, will allow pharmacists ... See full document

... GLP-1 RAs have proven to be a major advancement in the treatment of T2D. Currently, there are five GLP-1 RAs approved for use in the US and six approved for use in the EU (Figure 1). As a class, these agents offer many ... See full document

... The diabetes mellitus cohort was found to have increased incidence of hepatocellular carcinoma (pooled HR ...fixed effect) and worse overall mortality (pooled RR ...fixed effect) in comparison with ... See full document