[PDF] Top 20 Effects of Phosphorylation of Herpes Simplex Virus 1 Envelope Glycoprotein B by Us3 Kinase In Vivo and In Vitro
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Effects of Phosphorylation of Herpes Simplex Virus 1 Envelope Glycoprotein B by Us3 Kinase In Vivo and In Vitro
... The herpes simplex virus 1 (HSV-1) Us3 gene encodes a serine/threonine protein kinase with an amino acid sequence that is conserved in the subfamily Alphaherpesvirinae (9, ... See full document
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Role of the Herpes Simplex Virus 1 Us3 Kinase Phosphorylation Site and Endocytosis Motifs in the Intracellular Transport and Neurovirulence of Envelope Glycoprotein B
... dorabies virus (PRV), human cytomegalovirus (HCMV), and varicella-zoster virus (VZV) (4, 13, 18, ...the effects of these motifs on the regulation of gB intracellular transport, proper localization ... See full document
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Phosphorylation of a Herpes Simplex Virus 1 dUTPase by a Viral Protein Kinase, Us3, Dictates Viral Pathogenicity in the Central Nervous System but Not at the Periphery
... that Us3 phosphorylated vdUTPase at serine 187 (Ser-187) in infected cells ...34). Us3 phosphorylation of vdUTPase at Ser-187 appeared to regulate op- timal activity of vdUTPase in infected cells, ... See full document
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The UL12 Protein of Herpes Simplex Virus 1 Is Regulated by Tyrosine Phosphorylation
... The herpes simplex virus 1 (HSV-1) UL12 protein (pUL12) is a nuclease that is critical for viral replication in vitro and neuro- virulence in ...pUL12 phosphorylation ... See full document
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Differences in the Regulatory and Functional Effects of the Us3 Protein Kinase Activities of Herpes Simplex Virus 1 and 2
... kinase’s effects in infected cells, the kinase’s physiological sub- strates and its phosphorylation sites must be ...mutant virus lacking the protein kinase activity is also detected in cells ... See full document
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Identification of a Physiological Phosphorylation Site of the Herpes Simplex Virus 1-Encoded Protein Kinase Us3 Which Regulates Its Optimal Catalytic Activity In Vitro and Influences Its Function in Infected Cells
... pBS-VenusA206K- Us3 and pBS-VenusA206K-Us3S147A for generating a recombinant HSV-1 expressing a fusion protein of the Venus FP and Us3 or Us3S147A protein, respectively, were constructed as ... See full document
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Regulation of the Catalytic Activity of Herpes Simplex Virus 1 Protein Kinase Us3 by Autophosphorylation and Its Role in Pathogenesis
... The herpes simplex virus 1 (HSV-1) Us3 gene encodes a serine/threonine protein kinase with an amino acid sequence that is conserved in the subfamily Alphaherpesvirinae (8, ... See full document
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Phosphorylation of the UL31 Protein of Herpes Simplex Virus 1 by the US3-Encoded Kinase Regulates Localization of the Nuclear Envelopment Complex and Egress of Nucleocapsids
... have been observed in cells infected with viruses lacking the capacity to produce glycoproteins H and B (gH and gB, re- spectively) (8). Because these proteins are required for fusion with the plasma membrane or ... See full document
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Herpes Simplex Virus 1 Glycoprotein B and US3 Collaborate To Inhibit CD1d Antigen Presentation and NKT Cell Function
... HSV-1 US3 protein collaborates with gB to downregulate CD1d ...conserved glycoprotein in the Herpesviridae family and plays a key role in mediating fusion between viral envelope and host cell ... See full document
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Characterization of a Herpes Simplex Virus 1 (HSV-1) Chimera in Which the Us3 Protein Kinase Gene Is Replaced with the HSV-2 Us3 Gene
... by herpes simplex virus 1 (HSV-1) and 2 (HSV-2) play important roles in viral replication and ...HSV-1 Us3 and HSV-2 Us3 in cells infected by viruses with all the ... See full document
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Herpes Simplex Virus 1 Protein Kinase Us3 Phosphorylates Viral Envelope Glycoprotein B and Regulates Its Expression on the Cell Surface
... protein kinase acts in infected cells, the kinase’s physiological substrate(s) and its phosphorylation site(s) must be ...mutant virus lacking protein kinase activity also is detected in those ... See full document
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Herpes Simplex Virus 1 Protein Kinase Us3 Phosphorylates Viral dUTPase and Regulates Its Catalytic Activity in Infected Cells
... Herpes simplex virus 1 (HSV-1) is one of the best-character- ized members in the subfamily Alphaherpesvirinae of the family Herpesviridae and is the etiologic agent of a variety of ... See full document
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In Transduced Cells, the US3 Protein Kinase of Herpes Simplex Virus 1 Precludes Activation and Induction of Apoptosis by Transfected Procaspase 3
... in radioimmunoprecipitation assay buffer (1% Nonidet P-40, 0.5% sodium de- oxycholate, 0.1% sodium dodecyl sulfate in PBS) in the presence of protease inhibitors (Complete; Roche) as recommended by the ... See full document
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Herpes Simplex Virus Protein Kinases US3 and UL13 Modulate VP11/12 Phosphorylation, Virion Packaging, and Phosphatidylinositol 3-Kinase/Akt Signaling Activity
... deleting US3 dramatically reduces the amount of VP11/12 packaged into HSV-2 virions ...⌬ US3, and ⌬ US3R ...⌬ US3, or ⌬ UL46 ⌬ US3 virus, the UL13 deletion virus d13lacZ, the ... See full document
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Herpes Simplex Virus 1 ICP22 Regulates the Accumulation of a Shorter mRNA and of a Truncated US3 Protein Kinase That Exhibits Altered Functions
... 5% newborn calf serum in the presence of 6 or 9 mM sodium butyrate (Sigma). In some experiments, cells were exposed to 10 M proteasome inhibitor MG132 (Biomol) or caspase inhibitors (2 M DEVD or 50 M Z-VAD-FMK from ... See full document
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Identification of Functional Domains in Herpes Simplex Virus 2 Glycoprotein B
... in virus entry into cells, each mutant was tested for the ability to complement a gB- minus ...Table 1 and ...with virus, sug- gesting that gB is released from cells in membranous structures even in ... See full document
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Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion.
... 2596-2604 0022-538X/88/082596-09$02.00/0 Copyright C 1988, American Society for Microbiology Role of Glycoprotein B of Herpes Simplex Virus Type Entry and Cell Fusion 1 in Viral WEIZHONG[r] ... See full document
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Synthesis and processing of glycoprotein D of herpes simplex virus types 1 and 2 in an in vitro system.
... A Lane 1, modified gD-1 mock digested with trypsin and immunoprecipitated with anti-gD-1 serum; lane 2, modified gD-1 mock digested with trypsin and immunoprecipitated with group VII 170[r] ... See full document
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Herpes Simplex Virus Type 1 Evades the Effects of Antibody and Complement In Vivo
... varicella-zoster virus, and pseudorabies virus, while C-interacting proteins are also expressed by many her- pesviruses, including HSV-1 and -2, pseudorabies virus, equine herpesvirus type ... See full document
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Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture.
... Kovler Viral Oncology Laboratories, University of Chicago, Chicago, Illinois 606372 Received 16 April 1987/Accepted 11 June 1987 We report that a novel protein kinase previously shown to[r] ... See full document
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