[PDF] Top 20 AN EFFICIENT PROTOCOL FOR THE SYNTHESIS OF 1,2,4 TRIAZOLO[1,5 A]PYRIMIDINES
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AN EFFICIENT PROTOCOL FOR THE SYNTHESIS OF 1,2,4 TRIAZOLO[1,5 A]PYRIMIDINES
... In nutshell, an efficient method for the preparation of substituted triazolopyrimidine catalyzed by dimethylformamide under neutral and solvent-free conditions. Moderate to good yields of the corresponding to ... See full document
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A Simple and Efficient Microwave Assisted Synthesis of Pyrazolo [3,4-D] [1,2,4] Triazolo [1,5-A] Pyrimidines
... and 4-methoxy aldehyde ...the synthesis of pyrazolo[3,4- d ][1,2,4]triazolo[1,5- a ]pyrimidines, the reaction was also carried out using ultrasonic waves as an assisted ... See full document
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Synthesis of Diverse 1, 2, 4-Triazolo[1,5-A]Pyrimidine Derivatives
... organic synthesis has become an important tool to medicinal chemists for rapid organic ...assisted synthesis of 1,2,4-triazolo[1,5-a]pyrimidines has been ...spectra, 1 H ... See full document
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SIMPLE AND EFFICIENT PROTOCOL FOR THE SYNTHESIS OF 1, 2, 4, 5 TETRASUBSTITUTED IMIDAZOLES PROMOTED BY BISMUTH (III) BROMIDE
... and efficient protocol has been developed for the synthesis of 1, 2, 4, 5-tetrasubstituted imidazoles via four-component using like 1,2-diketones, aryl aldehydes, aryl ... See full document
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A Swift, Expedient and Solvent Less Synthesis of Highly Diversified 1,2,4-Triazolo [1,5-A] Pyrimidines Bearing Pyridine Scaffold
... A, synthesis of 1,2,4-triazolo[1,5-a]pyrimidines bearing pyridine scaffold is based on the Biginelli like cyclocondensation of aromatic aldehydes and acetoacetamide with aminoazoles containing a ... See full document
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A one pot microwave irradiation synthesis of 1,2,4 triazolo[1,5 a]pyrimidines
... the synthesis, reactivity, spectroscopic characterization and crystallographic studies of 1,2,4-triazolo[1,5- c]pyrimidines[2], 1,2,4-triazolo[4,3-a]pyrimidines[3] and ...CDK- ... See full document
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An one pot multi component synthesis of novel 1,2,4 triazolo[1,5 a]pyrimidines
... From the standpoint of biological activity, fused heteroaromatic systems are often of much greater interest than the constituent monocyclic compounds. Recently, 1,2,4-triazolo[1,5-a]pyrimidines have aroused ... See full document
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Microwave Assisted Synthesis of Chalcone based 1,2,4-triazolo [1,5-a] Pyrimidines
... While fire is now rarely used in synthetic chemistry, it was not until Robert Bunsen invented the burner in 1855 that the energy from this heat source could be applied to a reaction vessel in a focused manner. The Bunsen ... See full document
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Novel Ethyl 2 (1 aminocyclobutyl) 5 (benzoyloxy) 6 hydroxy pyrimidine 4 carboxylate Derivatives: Synthesis and Anticancer Activities
... of 2, 4, 5, 6-substituted pyrimidines, several ethyl 2-(1-aminocyclobutyl)-5-(benzoy- loxy)-6-hydroxy-pyrimidine-4-carboxylate derivatives associated with the ... See full document
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Efficient synthesis and antimicrobial evaluation of some Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones
... Results: In this study, a novel, rapid, and efficient protocol is developed for the synthesis of various 2-arylidine-1-thia-4- azaspiro[4.5]decan-3-ones using sodium ... See full document
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SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME NEW 1, 6 DIPHENYL 10, 10a DIHYDROPYRIDO[2, 3 d] 1, 2, 4 TRIAZOLO [4, 3 a]PYRIMIDIN 5(1H) ONE DERIVATIVES
... MATERIALS AND METHODS: The chemicals, solvents, drugs employed for synthetic work were of BDH/Hi-Media/E-Merck/Laboratory grade. The solvents were further purified by established methods 3 . The starting material used in ... See full document
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Nano Silica Phosphoric Acid: An Efficient Catalyst for the One- Pot Synthesis of 1, 2, 4, 5-Tetrasubstituted Imidazoles
... to 1:1:1:0.06.The ultrasonic assisted synthesis of the present reaction was studied by using SPA or nano-SPA in ethyl acetate under reflux conditions (Table 1, entries ... See full document
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One pot, four component sequential synthesis of novel 4 arylamino 5 carboxyl pyrimidine derivatives
... hand, efficient high-throughput synthesis of organic compounds via multi-component reactions (MCRs) plays an important role in combinatorial chemistry and modern drug discovery[15] because of its capability ... See full document
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Highly Efficient Synthesis of 2-substituted 4(3H)-quinozolinones Derivatives Using Boron Tribromide as a Catalyst
... 26. (a) J. Zhou, L. Fu, M. Lv, J. Liu, D. Pei, K. Ding Synthesis. 2008, 31, 3974-3980. (b) C. Huang, Y. Fu, H. Fu, Y. Jiang, Y. Zhao, Chem. Commun. 2008, 33, 6333-6335. (c) X. Liu, H. Fu, Y. Jiang, Y. Zhao, Angew. ... See full document
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Synthesis, Antimicrobial, Antioxidant and Molecular Docking Study of Some Novel Bis-1, 2, 4-Triazolo [3, 4-b]-1, 3, 4-Thiadiazoles
... All the compounds (5a-i) were found to have minimum binding energy ranging from -5.19 to -8.99 kJ/mol with antimicrobial Acinetobacter baumannii penicillin-binding protein target (PDB Code: 3UDI). Among the molecules ... See full document
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Synthesis and Antimicrobial Evaluation of 8-[{4- (2-Substituted Phenyl–5-Oxo-Thiazolidin-1-Yl)- 5-Thiobutyl Triazolo} Methoxy] Quinolines
... Thioglycolic acid (.01 mole) and a pinch of anhydrous ZnCl 2 was added to a methanolic solution of compounds 5-6 (.01 mole). The reaction mixture was refluxed for 8-10 hrs. and completion of the reaction ... See full document
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Synthesis, Characterization and Anticonvulsant Activity of Some Novel 4, 5-Disubstituted-1, 2, 4-Triazole Derivatives
... Scheme 1. The methyl- 3-amino-4-hydroxybenzoate (2) was prepared according to the method reported in the literature (Gopalakrishna et ...methyl 2- ... See full document
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Studies in pyrimidine chemistry
... for 5 mins, and was then extracted with 5 x 20cm portions of diethyl ...give 4-chloro-5~(2-thienyl) .... 4-hydrazino- 5( 2- thienyl) pyrimidine (XIII; X = ... See full document
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STUDIES DIRECTED TOWARDS THE SYNTHESIS OF PYRANICIN AND DEVELOPMENT OF NEW SYNTHETIC METHODOLOGIES
... Pyranicin(1), a novel member of the annonaceous acetogenin family of natural products, was isolated in 1997 by McLaugh-lin and co-workers from the stem bark of the Goniothalamusgiganteus tree native to Thailand. ... See full document
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[1 (4 Nitrobenzyl) 2 butyl 4 chloro 1H imidazol 5 yl] 4, 5 dihydro 1 phenyl 1H pyrazole: Synthesis, Anti Inflammatory and Analgesic Activities
... This method is based on acetic-acid-induced writhings in mice [23]. Groups of six mice each were dosed with the test compounds or with aspirin at a dose of 100 mg/kg po, 1 h before the ip injection of 0.6% acetic ... See full document
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