[PDF] Top 20 The emerging roles and functions of circular RNAs and their generation

... known functions of cir- cRNAs in cell proliferation, EMT, development and other cellular ...circRNA functions and regulation, many questions remain to be ...different roles in normal physiology and ... See full document

... invasion of triple-negative breast cancer cells in vivo. 26 CircPVT1 serves as a ceRNA of miR-497 and indirectly regulates Bcl-2 expression in non-small cell lung cancer cells, thereby promoting the progression of ... See full document

... Recently, it is shown that some classes of the enzyme are effective in circRNAs biogenesis. RNA binding pro- teins (RBPs) is a group of enzymes that have a role in the generation of circRNAs in some situations and ... See full document

... rapidly. Circular RNAs (circRNAs), the 3 ′ and 5 ′ ends of which are covalently linked, constitute a class of RNA recently discovered to be widespread and abundant (Salzman et ...functional roles for ... See full document

... critical roles of circRNAs in the pathogenesis of a large number of human diseases, including heart diseases [7], diabetes [8], nervous system diseases [9], immune sys- tem diseases [10] and cancers ... See full document

... Metabolism is the set of life-sustaining chemical transfor- mations within the cells of organisms. Most of the struc- tures that make up living organisms are made from three basic classes of molecule: carbohydrates, ... See full document

... other RNAs including circular RNAs ...non-coding RNAs, long noncoding precisely; evidence of translations has been reported from these ...considered emerging new members of the gene ... See full document

... noncoding RNAs, includ- ing mRNAs and lncRNAs, studies concerning circRNAs in NSCLC are just ...locus, functions as a miR-7 ...exert functions in the development of therapies against NSCLC ...their ... See full document

... noncoding RNAs (lncRNAs) are emerging as an important set of molecules because of their roles in various key pathophysiological pathways, including cell growth, apoptosis, and ...the ... See full document

... In order to reveal the relationship between exon skip- ping and circRNA biogenesis, the expression patterns of the cytochrome P-450 2C18 gene in human epidermis and the androgen binding protein (ABP) gene in rat tes- tes ... See full document

... While circular RNA (circRNA) is increasingly attracting attention from researchers, at the same time, its mystery has gradually been ...and functions of circRNA and common laboratory detection methods ... See full document

... long-noncoding RNAs (lncRNAs), which are capable of interactions with DNA, RNA and protein molecules, thereby enabling a variety of transcriptional and post-transcriptional regulatory ...potential functions ... See full document

... diverse functions in mammalian physiology and research of these genes is continuing to grow ...biological functions, but also help devise more rational application of sirtuin inhibitors or activators for ... See full document

... Research interest in the physiologic and pathologic roles of circRNAs is growing. Although some individual circRNAs have been characterized, the functions of circRNAs remain largely unknown. The ability of ... See full document

... biological roles of circRNAs in cancer development and ...the functions of cir- cRNAs in cancer, such as the regulation of gene or protein activities, need to be further ...addition, ... See full document

... an emerging key player with intriguing molecular functions in the RNA ...of functions, including sponge, regulation mole- cules, translation, biomarker and tumor suppressor are regarded as vital ... See full document

... endogenous RNAs (ceRNAs) contain shared MREs, such as mRNAs, pseudogenes, and long noncoding RNAs (lncRNAs), and can compete for miRNA binding ...lar functions [42] and play important roles in ... See full document

... 2. Roles of circRNAs in the occurrence and development of ...circRNAs, circular RNAs; OS, osteoarthritis; ECM, extracellular matrix; circRNA-CER, chondro- cyte extracellular matrix related circRNAs; ... See full document

... family. Emerging evidence suggests that ADAMTS-7 and ADAMTS-12 may play an important role in the development and pathogenesis of various kinds of ...the roles of these two metalloproteinases, with a special ... See full document

... Because Sema3s are diffusible factors, they can affect the overall growth of tumors by direct mechanisms that influ- ence tumor cell physiology, and/or by indirect mechanisms affecting the tumor microenvironment (TME). ... See full document