[PDF] Top 20 Emerging Roles of Long Non-Coding RNAs as Drivers of Brain Evolution

... Apart from their role in transcriptional and post-transcriptional regulation, lncRNAs are known to act on translation, as described previously. Local protein translation is of particular relevance to maintain dendritic ... See full document

... [13]. Emerging studies have shown that long noncoding RNAs (lncRNAs) play critical roles in carcinogenesis and progression by modulating the expression of many oncogenes or tumor suppressor ... See full document

... Recently, long intergenic non-coding RNAs (lincRNAs) were reported to play important roles in mental ...mortem brain tissues from three brain regions (orbitofrontal cortex ... See full document

... the non-coding transcripts are now believed to provide a very complex multi-layered regulatory network essential for generating and maintaining the self-organized state of living organisms (Lakhotia, 1996, ... See full document

... are emerging as key regulators of distinct developmental processes in animals and ...of non- coding RNAs are evolutionarily conserved and expressed in early embryos, suggesting that they might ... See full document

... the PRNCR1 rs13252298, rs1456315 and rs7841060 polymorphisms could be used as a biomarker for PCa development (10). Understanding the mechanisms involved in AR activation in the milieu of low androgen may be crucial for ... See full document

... duce non-coding RNAs (ncRNAs) ...protein coding potential [25]. lncRNAs play critical roles in mul- tiple biological and pathological processes, including embryonic development, cell ... See full document

... of brain cytoplasmic RNA 1 (BCYRN1) to induce NSCLC cell proliferation and invasion is primarily due to the elevated expression of cell cycle- related proteins CDK4 and some crucial components of the Wnt/ β ... See full document

... therapy. Long non-coding RNAs (lncRNAs) are involved in cancer development and progression by the regulation of processes related to chromatin remodeling, transcription, and ... See full document

... of long non-coding RNAs (lncRNAs) play critical roles in these processes as ...regulatory roles of lncRNAs in transcriptional control during cellular stress response in higher ... See full document

... the emerging roles of lncRNAs was recently proposed as fol- lows: the signal archetype, a molecular signal or indica- tor of transcriptional activity; the decoy archetype, which binds with other regulatory ... See full document

... LncRNAs play critical roles in epigenetic modulation of chromatin structure by regulating key genes in spe- cific cancerous cells [186,187]. Distinct chromatin signa- tures are associated with lncRNAs encoding ... See full document

... In regards to the RAAS-regulated genes, it appears that miRNAs may also have a role modulating ACE mRNA transcription [29]. MiRNA has-miR-155 was found by Sethupathy et al. [55] to target the polymorphic sequence located ... See full document

... a long intervening non-coding RNA (lincRNA) transcribed from the HOXC locus, which participates in epigenetic regulatory processes, cooperates with polycomb repressive complex 2 and is required for ... See full document

... the coding sequences, RPFs between 27 and 32 nts (totaling 220 million) were deemed to be high quality and were used in subsequent ...annotated coding regions of RefSeq ... See full document

... to play various roles in modulation of the YAP signal- ing pathways in the cytoplasm of pancreatic cancer cells [37]. In one mechanism, LINC01559 can act as a miRNA sponge of miR-607 to upregulate the expression ... See full document

... Although lncRNAs provide a possible new research direction to elucidate the mechanism of drug resistance in BC, therapies based on lncRNAs have not been applied to the clinical treatment of BC. Treatments based on ... See full document

... Metastasis-associated lung adenocarcinoma transcript 1(MALAT1) is a large, infrequently spliced 7.5 kb in length lncRNA located in chr11q13. MALAT1 was first identified by its link in non-small cell lung cancer ... See full document

... them is genome wide association studies – GWAS. In this case, single nucleotide polymorphisms (SNP), associated with a particular condition are investigated. To date there are only a few examples of using GWAS in the ... See full document

... sRNAs: non-coding RNA-associated small RNAs (nasRNAs); sRNAs that overlap promoter regions ( pasRNAs), which overlap with the transcription start site (TSS) of genes; exon-associated small ... See full document