[PDF] Top 20 Enhanced Human-Type Receptor Binding by Ferret-Transmissible H5N1 with a K193T Mutation
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Enhanced Human-Type Receptor Binding by Ferret-Transmissible H5N1 with a K193T Mutation
... avian H5N1 viruses are associated with a high mortality rate in several species, including ...Fortunately, H5N1 viruses do not transmit be- tween humans because they do not bind to human-type ... See full document
10
An Avian Influenza H5N1 Virus That Binds to a Human-Type Receptor
... whereas human influenza viruses preferentially recognize ...the human population, which can lead to pandemics. Avian influenza H5N1 virus is a major threat for the emergence of a pandemic ...312 ... See full document
6
Hemagglutinin Receptor Specificity and Structural Analyses of Respiratory Droplet-Transmissible H5N1 Viruses
... of H5N1 viruses in ferrets reported respiratory droplet-transmissible variants with mutations in the receptor-binding site (RBS) and stalk domain (5, ...of human influenza viruses, in ... See full document
6
A Point Mutation in the RNA-Binding Domain of Human Parainfluenza Virus Type 2 Nucleoprotein Elicits Abnormally Enhanced Polymerase Activity
... RNA- binding domain of hPIV2 NP for polymerase activity using ...Abnormally enhanced genome replication was observed upon substitution mutation of the NP Q202 position to various amino ...this ... See full document
14
Mutation at Residue 523 Creates a Second Receptor Binding Site on Human Parainfluenza Virus Type 1 Hemagglutinin-Neuraminidase Protein
... second binding site on human parainfluenza virus (hPIV) type 1, 2, and 3 and Sendai virus (SeV) HN ...the receptor only through the NA catalytic site, while SeV HN has an additional ... See full document
8
A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice
... for binding to host cell receptors and therefore influences the viral host range and pathogenicity in different ...virus receptor binding speci- ficity but enhances virus binding affinity of ... See full document
20
A Mutation in the First Ligand-Binding Repeat of the Human Very-Low-Density Lipoprotein Receptor Results in High-Affinity Binding of the Single V1 Module to Human Rhinovirus 2
... acidic residue (E in V2 and D in V3). The reasons to change the arginine and the valine are obvious; threonine was replaced by proline, based on the assumption that this might have an effect on the local conformation of ... See full document
7
Mutations in Hemagglutinin of H5N1 Influenza That Switch Receptor Specificity from Avian to Human Types
... avian H5N1 influenza transmissible among people since the first report of human infections with this virus in ...avian H5N1 influenza transmissible between ferrets through the air, ... See full document
6
The E545K mutation of PIK3CA promotes gallbladder carcinoma progression through enhanced binding to EGFR
... of receptor protein kinases or adaptor proteins through interactions with p85 and subsequently activates the lipid kinase activity of p110α ...in human cancers occur within two hot spots: E545K and ...E545K ... See full document
12
Mutation of the SP1 Sequence Impairs both Multimerization and Membrane-Binding Activities of Human Immunodeficiency Virus Type 1 Gag
... transferrin receptor (TfR), or Gag proteins in the sucrose ...ferrin receptor, is resistant to Brij 98 ...wild- type (WT) and mutated Gag proteins (data not ... See full document
10
Receptor binding specificity of recent human H3N2 influenza viruses
... cell binding assay The Glycoarray showed no specificity differences between viruses that bind chicken red cells and those that do not, suggesting the difference either involves structures that are not on the ... See full document
11
Modest Human Immunodeficiency Virus Coreceptor Function of CXCR3 Is Strongly Enhanced by Mimicking the CXCR4 Ligand Binding Pocket in the CXCR3 Receptor
... This is, to our knowledge, the first demonstration that CXCR3 can serve as a potential coreceptor for several HIV strains and clinical isolates, although its receptor efficiency is by several orders of magnitude ... See full document
8
A Second Receptor Binding Site on Human Parainfluenza Virus Type 3 Hemagglutinin-Neuraminidase Contributes to Activation of the Fusion Mechanism
... definable binding pockets in this region in the (low-temperature) crystal structure; the site II observed in our modeling results from minor side chain rearrangements that would be reasonable under the biological ... See full document
13
GLUT1 Is Not the Primary Binding Receptor but Is Associated with Cell-to-Cell Transmission of Human T-Cell Leukemia Virus Type 1
... a binding receptor for human T-cell leukemia virus type 1 ...GLUT1 enhanced HTLV-I transfer, efficient virus spread correlated largely with heparan sulfate proteoglycan (HSPG) ... See full document
5
Binding of CLL Subset 4 B Cell Receptor Immunoglobulins to Viable Human Memory B Lymphocytes Requires a Distinctive IGKV Somatic Mutation
... two type 2 termini, one of which is linked to the C6 posi- tion of the polylactosamine backbone, Galβ-4GlcNAcβ-6(Galβ-4GlcNAcβ-3) ...with type 1 (Galβ- 3GlcNAc-) terminus, Galβ- 3GlcNAcβ-3Galβ- ... See full document
12
Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses
... the binding data, antibody ...pathogenic H5N1 avian influenza viruses elicit human B cell responses encoding potently neutralizing antibody clones that are able to bind rdt viral variants (1, ...rdt ... See full document
6
Inefficient Transmission of H5N1 Influenza Viruses in a Ferret Contact Model
... contact ferret developed neutralizing antibodies to A/Hong Kong/213/03 but did not exhibit any clinical signs or detectable virus ...contact ferret to the other naı¨ve ferret that were housed ... See full document
9
Alternative Reassortment Events Leading to Transmissible H9N1 Influenza Viruses in the Ferret Model
... D120N mutation lies in a region of PB1 with no described function, but the base pair substitution (G382A) does result in a 3-amino-acid (aa) truncation of PB1-F2 (90 aa to 87 aa) (27, ...This mutation was ... See full document
6
Human cytomegalovirus binding to fibroblasts is receptor mediated.
... Specific binding values (0, *, and A) were obtained by subtracting nonspecific linear binding values (0, O, and A), obtained from identical samples containing a 25-fold excess of unlabel[r] ... See full document
8
Cellular receptor binding and entry of human papillomavirus
... initial binding to a primary receptor and then transfer to a secondary receptor allowing for invasion of ...secondary receptor, contributed individually or in combination to the ...virus ... See full document
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