[PDF] Top 20 Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes
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Epigenetic mechanisms of endothelial dysfunction in type 2 diabetes
... some epigenetic alterations have been observed in the NF-kB promoter region, leading to increased expression of NF-kB subunit p65, such as: 1) recruitment of the his- tone methyltransferase Set7 and increased ... See full document
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EFFECT OF FENOFIBRATE ADJUVANT THERAPY ON ENDOTHELIAL DYSFUNCTION AND CARDIOVASCULAR RISK IN EGYPTIAN PATIENTS WITH TYPE 2 DIABETES MELLITUS
... Objective: Endothelial dysfunction is afflicted to the maturation of arteriosclerosis and type 2 diabetes mellitus (T2DM) vascular ...on endothelial dysfunction and ... See full document
8
Protective effect of sitagliptin and rosuvastatin combination on vascular endothelial dysfunction in type-2 diabetes
... and endothelial dysfunction in the aortic tissues in fructose-fed type-2 diabetic ...of diabetes by fructose (66%, w/v solution, ...phenylephrine. Endothelial dysfunction ... See full document
7
HIV infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation
... Since endothelial dysfunction is an early step in the atherosclerotic process, this association is not surprising and it fits well with our previous finding of a close associ- ation between soluble CD14 and ... See full document
8
Folic acid: a marker of endothelial function in type 2 diabetes?
... Objectives: Endothelial dysfunction is a common feature of type 2 ...on endothelial function, beyond the well known homocysteine lowering ...determine endothelial-dependent ... See full document
5
Endothelial cell dysfunction and the vascular complications associated with type 2 diabetes: assessing the health of the endothelium
... of type 2 diabetes and support a possible role for inflammation in diabetogenesis (Pradhan et al ...of type 2 diabetes, provide a similar correlation between acute-phase proteins ... See full document
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Assessment of dapagliflozin effect on diabetic endothelial dysfunction of brachial artery (ADDENDA-BHS2 trial): rationale, design, and baseline characteristics of a randomized controlled trial
... ED: endothelial dysfunction; T2DM: type 2 diabetes mellitus; IRI: ischemia and reperfusion injury; FMD: flow mediated dilation; NO: nitric oxide; SGLT2i: sodium/glucose cotransporter ... See full document
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Original Article Epigenetic regulation of microRNA-375 and its role as DNA epigenetic marker of type 2 diabetes mellitus in Chinese Han population
... was epigenetic regulat- ed in gastric and breast cancers [17, 18], but no studies have directly linked the miR-375 pro- moter methylation to ...by epigenetic mechanisms in the Chinese Han patients ... See full document
9
Is tetrahydrobiopterin a therapeutic option in diabetic hypertensive patients?
... factor. Endothelial function is altered in patients with coronary artery disease, stroke, and peripheral artery disease, and endothelial dysfunction correlates with the risk factor profile for a ... See full document
8
Insulin resistance, endothelial function and non-esterified fatty acids in health and type 2 diabetes
... hypertension, type 2 diabetes or insulin resistance are more common in adults who had an abnormally low birth weight ...that endothelial dysfunction is a consequence o f fetal ... See full document
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Relationship among HbA1c and Some Markers of Endothelial Damage in Type 2 Diabetes Mellitus
... International Diabetes Federation (IDF) estimated that, in 2011, 366 million people worldwide were already living with diabetes and that 80% of these individuals were based in low and middle income ...of ... See full document
6
Effect of type 2 diabetes on the dynamic response characteristics of leg vascular conductance during exercise
... by type 2 diabetes, the slowed second phase response is probably not due to a lower preceding flow stimulus and above-mentioned mechanisms that underlie it and is perhaps more likely explained ... See full document
10
Type 2 Diabetes and Memory: Using Neuroimaging to Understand the Mechanisms
... Disturbances in glucose metabolism, including hypergly- caemia and hypoglycaemia, have been associated with cog- nitive dysfunction [7, 9]. Summerfield, Deary and Frier [7] observed that induced acute ... See full document
6
Endothelial dysfunction: Mechanisms and reversal in insulin resistance and diabetes mellitus
... examined endothelial function in the brachial ...normoalbuminuric type 1 DM patients and ...of endothelial function in type 1 DM ...of diabetes but not having developed any ... See full document
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Excessive visit-to-visit glycemic variability independently deteriorates the progression of endothelial and renal dysfunction in patients with type 2 diabetes mellitus
... Brachial flow-mediated dilation (FMD) of reactive hyperemia is known to be endothelium-dependent and a widely accepted noninvasively clinical method for asses- sing systemic endothelial functions [19, 20]. ... See full document
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Folate and Vitamin B6 Rapidly Normalize Endothelial Dysfunction In Children With Type 1 Diabetes Mellitus
... elbow and proximal to the placement of the blood pres- sure cuff, was measured in longitudinal section from 2-dimensional ultrasound images by using a standard HDI 3000 ultrasound system (Advanced Technology ... See full document
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Cellular and molecular mechanisms of endothelial dysfunction in diabetes.
... of endothelial nitric oxide synthase (eNOS), NO diffuses into neighbouring vascular smooth muscle cells (SMC) activating guanylyl cyclase and producing cGMP and activating kinases responsible for vascular ...to ... See full document
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Advanced glycation endproducts in the pathogenesis of chronic kidney disease
... carboxymethyl-lysine (CML) and glucosepane. They contribute to the development of chronic kidney disease (CKD). Cellular proteolysis of AGE-modified proteins forms AGE free adducts, glycated amino acids, which are ... See full document
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Mechanisms and Drivers of Type 2 Diabetes in Children and Adolescents
... In an effort to expand treatment strategies for T2D in children and adolescents, the Treatment Options for Type 2 Diabetes in Youth (TODAY) study was conducted and recently published its results ... See full document
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Clinical significance of procoagulant microparticles
... Galli et al. [94] performed a study of PDMPs in throm- botic thrombocytopenic purpura (TTP) and found a rise and fall in PDMP levels with the course of the disease, suggesting that PDMPs are clinically relevant. Jimenez ... See full document
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