[PDF] Top 20 Evolution of Human Immunodeficiency Virus Type 1 in a Patient with Cross-Reactive Neutralizing Activity in Serum
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Evolution of Human Immunodeficiency Virus Type 1 in a Patient with Cross-Reactive Neutralizing Activity in Serum
... ent replication fitness may coexist for a certain amount of time but that a changing environment in the host with progression of disease may favor the persistence of HIV-1 variants with the most fit and ... See full document
6
Autologous Neutralizing Humoral Immunity and Evolution of the Viral Envelope in the Course of Subtype B Human Immunodeficiency Virus Type 1 Infection
... autologous virus variants was observed only in patients H1, H2, and ...46), virus variants were not neutralized by contemporaneous serum and sera from ear- lier time points, suggestive of viral ... See full document
10
Primary Virus Envelope Cross-Reactivity of the Broadening Neutralizing Antibody Response during Early Chronic Human Immunodeficiency Virus Type 1 Infection
... the neutralizing antibody responses, the development of neutral- ization resistance as a result of mutations at sites distant from neutralization epitopes is well documented in work by our laboratory and others ... See full document
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Induction and Characterization of Neutralizing Antibodies against a Human Immunodeficiency Virus Type 1 Primary Isolate
... of neutralizing antibodies by recombinant DH012 ...chimpanzee serum exhibits such po- tent neutralizing activity raised the possibility of reproducing this activity by immunizing ... See full document
5
Neutralizing Antibody Responses in Acute Human Immunodeficiency Virus Type 1 Subtype C Infection
... the virus to remain CD4 dependent, as proposed previously ...heterologous virus COT6, which has been shown to be highly sensitive to the gp41 MAb 4E10 ...especially cross-reactive to ... See full document
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Role of Human Immunodeficiency Virus Type 1 Envelope Structure in the Induction of Broadly Neutralizing Antibodies
... A-infected patient has been described; this approach com- bines binding of Abs to recombinant gp120 and gp41 with a high- throughput microneutralization assay, resulting in the improve- ment of the quality of ... See full document
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Dissecting the Neutralizing Antibody Specificities of Broadly Neutralizing Sera from Human Immunodeficiency Virus Type 1-Infected Donors
... broadly neutralizing sera to different HIV-1 antigens and the envelopes of viral isolates present in these donors (6, 18, 63, ...mapping serum NAb specificities have fo- cused generally on immunized ... See full document
15
Cross-Clade Neutralizing Activity of Human Anti-V3 Monoclonal Antibodies Derived from the Cells of Individuals Infected with Non-B Clades of Human Immunodeficiency Virus Type 1
... from human volunteers infected with various strains of subtype B and non-B ...immunologic activity than do viruses bearing the GPGR ...nonneutralizing human anti-C2 MAb ...indicate virus/MAb ... See full document
8
Antibodies That Are Cross-Reactive for Human Immunodeficiency Virus Type 1 Clade A and Clade B V3 Domains Are Common in Patient Sera from Cameroon, but Their Neutralization Activity Is Usually Restricted by Epitope Masking
... the cross-reactive Camerooninan sera might have been due to the absence in these Envs of the epitopes for the neutralizing antibodies or to masking effects that prevent bind- ing of V3-directed ... See full document
11
Identification and Antigenicity of Broadly Cross-Reactive and Conserved Human Immunodeficiency Virus Type 1-Derived Helper T-Lymphocyte Epitopes
... Secondly, the epitope screening process used in this study is based on the ability of peptides to bind multiple HLA-DR alleles. van der Burg and colleagues recently reported the identification of a single ... See full document
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Llama Antibody Fragments with Cross-Subtype Human Immunodeficiency Virus Type 1 (HIV-1)-Neutralizing Properties and High Affinity for HIV-1 gp120
... isolating neutralizing VHH, we em- ployed a functional selection approach which enabled the identification of VHH that compete with ...B virus or sequen- tially on gp120 from subtypes A, B, and C, allowed ... See full document
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Potent Intratype Neutralizing Activity Distinguishes Human Immunodeficiency Virus Type 2 (HIV-2) from HIV-1
... calf serum (FCS), ...later, 1 ml plasma from the HIV-infected individuals was centrifuged at 18,000 rpm for ...resuspended virus pellet was then added to 500 l of infection medium containing 10 ⫻ 10 ... See full document
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Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies
... MPER-specific neutralizing Abs in patient SC44, from whom m66 and ...anti-dsDNA activity in the SC44 serum ...to human HEp-2 epithelial cells with a diffuse cytoplasmic and nuclear ... See full document
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Quantitation of HLA Proteins Incorporated by Human Immunodeficiency Virus Type 1 and Assessment of Neutralizing Activity of Anti-HLA Antibodies
... neutralization activity at a 1/10 dilution. Since HIV-1 inhibition due to undefined plasma components may be seen if a lesser dilution of plasma is used, IgG antibodies from plasma samples from two ... See full document
7
Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody That Recognizes a Novel Conformational Epitope on gp41 and Lacks Reactivity against Self-Antigens
... Broadly cross-reactive human immunodeficiency virus (HIV)-neutralizing antibodies are infrequently elic- ited in infected ...gp41-specific cross-reactive ... See full document
11
Induction of Primary Virus-Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Antibodies in Small Animals by Using an Alphavirus-Derived In Vivo Expression System
... without serum, the cells were incubated at 37°C for ⬃72 h, and the gp140-containing superna- tants were harvested at 24-h intervals and ...chemical cross-linking and ...vaccinia virus, including ... See full document
12
Generation of Neutralizing Activity against Human Immunodeficiency Virus Type 1 in Serum by Antibody Gene Transfer
... Construction of a dual plasmid vector for rAAV/IgG1b12 production. The coding sequences for the human monoclonal antibody, IgG1b12 were derived from plasmid pDR12. Isolation of IgG1b12 and plasmid pDR12 have been ... See full document
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Examination of sera from human immunodeficiency virus type 1 (HIV-1)-infected individuals for antibodies reactive with peptides corresponding to the principal neutralizing determinant of HIV-1 gp120 and for in vitro neutralizing activity.
... 5210-5215 0022-538X/92/095210-06$02.00/0 Copyright © 1992, American Society for Microbiology Examination of Sera from Human Immunodeficiency Virus Type 1 HIV-1-Infected Individuals for A[r] ... See full document
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Factors Associated with the Development of Cross-Reactive Neutralizing Antibodies during Human Immunodeficiency Virus Type 1 Infection
... QH0692 virus but plasma collected ...that cross-reactive NAbs that bind to as-yet unidentified conserved epitope(s) are generated during HIV ... See full document
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Identification of 81LGxGxxIxW89 and 171EDRW174 Domains from Human Immunodeficiency Virus Type 1 Vif That Regulate APOBEC3G and APOBEC3F Neutralizing Activity
... neutralize human A3G and A3F. Vif activity was measured by the levels of enhancement of ⌬ Vif HIV-1 infectivity in the presence of A3G or A3F expression in viral producer cells using a single-round ... See full document
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