[PDF] Top 20 Expression of c-myc is not critical for cell proliferation in established human leukemia lines
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Expression of c-myc is not critical for cell proliferation in established human leukemia lines
... of c- myc mRNA was obviously readily accessible since it was efficiently cleaved by RNase H in the presence of the initiation co- don antisense oligodeoxynucleotide [17], through only partial ... See full document
9
Decrease expression of microRNA-744 promotes cell proliferation by targeting c-Myc in human hepatocellular carcinoma
... HCC cell lines (HepG2, SMMC-7721, QGY-7703, BEL-7402) and human hepatic cell lines LO2 used in this study were purchased from the cell bank of the Chinese Academy of ... See full document
9
Impact of c-MYC expression on proliferation, differentiation, and risk of neoplastic transformation of human mesenchymal stromal cells
... experiments established that, indeed, in ex- panded MSC, there were high levels of c-MYC protein accumulation, and they further increased with the subse- quent passaging of these ...high ... See full document
18
PDZK1 Is a Novel Factor in Breast Cancer That Is Indirectly Regulated by Estrogen through IGF-1R and Promotes Estrogen-Mediated Growth
... PDZK1 expression and estrogen receptor (ER)- α stimulation has been suggested, the nature of such a connection and the function of PDZK1 in breast cancer remain ...unknown. Human tissue microarrays (cancer ... See full document
10
Original Article C-myc-regulated miR-106b promotes proliferation of human bladder cancer cells by targeting DAPK2
... of c-myc and miR-106b in the development of human bladder cancer ...the expression of miR-106 after the silence of c-myc by sh-RNA, and then western blotting assay was used to ... See full document
7
Molecular Cytotoxic Mechanisms of 1-(3,4,5-Trihydroxyphenyl)-dodecylbenzoate in Human Leukemia Cell Lines
... on human acute myeloid leukemia K562 cells and on human acute lymphoblastic leukemia Jurkat ...The cell viability was determined by MTT ...The cell cycle analysis was carried out ... See full document
9
RNAi silencing of c-Myc inhibits cell migration, invasion, and proliferation in HepG2 human hepatocellular carcinoma cell line: c-Myc silencing in hepatocellular carcinoma cell
... gene expression makes it a valuable research tool, both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest ...myeloid ... See full document
6
CD19 is a major B cell receptor–independent activator of MYC driven B lymphomagenesis
... B cell–specific transcription factor, is overexpressed through chromosomal translocations in a sub- set of B cell ...B cell receptor (BCR) signaling by PAX5 contributes to ...a MYC-induced ... See full document
11
MEK1 is required for the development of NRAS-driven leukemia
... in leukemia, in which pathway activation is caused by mutations in upstream components such as RAS or ...the proliferation of human leukemic cell lines and in retroviral models of ... See full document
18
Molecular analysis of the gastrulating mouse embryo and its germ cell lineage
... of cell growth and ...excessive proliferation, the division of normal cells must be tightly ...which c-sis is induced by #TGF, the release of the PDGF-like factor seems to stimulate activation of ... See full document
225
Induction of differentiation-associated changes in established human cells by infection with adeno-associated virus type 2.
... The mechanism of AAV-2-induced differentiation is not clear, and we do not know whether cessation of cell proliferation marked by a decrease of c-myc expression, arrest of cells in the G[r] ... See full document
10
Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer.
... silences c-Myc expression and downstream pathways in prostate cancer cell lines is consistent with a previous report ...cancer cell lines with high c-Myc ... See full document
11
<p>Effects of Wnt/β-Catenin Signal Pathway Regulated by miR-342-5p Targeting CBX2 on Proliferation, Metastasis and Invasion of Ovarian Cancer Cells</p>
... the expression level of miR-342-5p decreases dur- ing the occurrence of ovarian tumors, which reduces the inhibition of the transcription of its target gene CBX2, result- ing in an increase in the ... See full document
12
Haploinsufficiency of the c-myc transcriptional repressor FIR , as a dominant negative-alternative splicing model, promoted p53- dependent T-cell acute lymphoblastic leukemia progression by activating Notch1
... in leukemia cells compared with that in non-leukemia or control samples from adults (Figures 1G) and children (data not ...to c-myc upregulation in T-ALL. Notably, c-Myc ... See full document
16
Identification of the human T cell lymphoma virus in B cell lines established from patients with adult T cell leukemia
... Cell lines were established from the peripheral blood of two patients with adult T cell ...such lines expressed T cell markers, these two cell lines expressed B ... See full document
8
CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression
... activated MYC by CSIG in ...higher expression of MYC as compared with controls, which corresponded with in vitro experiments (Figure ...the expression of MYC and CSIG at protein levels ... See full document
12
Catalytic DNAs as potential therapeutic agents and sequence specific molecular tools to dissect biological function
... domain composed of 15 deoxynucleotides, flanked by two substrate recognition arms each composed of 7–8 bases that bind to target RNA through Watson-Crick base-pairing. The DNAzyme cleaves a specific phos- phodiester ... See full document
8
Differential effects of polyphenols on proliferation and apoptosis in human myeloid and lymphoid leukemia cell lines
... the leukemia cell lineage (lymphoid ...the cell lines from the same lineage. We have shown that myeloid cell lines (K562 and KG-1a) were particularly resistant even to the most ... See full document
14
Clinical significance of TIPE expression in gastric carcinoma
... a critical role in inter- fering with anticancer drug ...TIPE expression in BGC823, induced cell apoptosis was significantly elevated, showing a direct link between TIPE expression and tumor ... See full document
9
TGF β/β2 spectrin/CTCF regulated tumor suppression in human stem cell disorder Beckwith Wiedemann syndrome
... have defective TGF-β signaling, develop multiple tumors that are phenotypically similar to those of BWS patients. Moreover, tumorigenesis-associated genes IGF2 and telomerase reverse transcriptase (TERT) were ... See full document
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