[PDF] Top 20 Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1
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Expression of Human Endogenous Retrovirus Type K (HML-2) Is Activated by the Tat Protein of HIV-1
... Recombinant HIV-1 Tat activates HERV-K (HML-2) gene ...different Tat treatments and amplified by one-step Sybr green real-time qRT-PCR using primers specific for ... See full document
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Regulation of the Human Endogenous Retrovirus K (HML-2) Transcriptome by the HIV-1 Tat Protein
... the HIV-1 Tat Protein Marta ...of Human Genetics, i Program in Cancer Biology, j and Cellular and Molecular Biology Program, k University of Michigan, Ann Arbor, Michigan, ... See full document
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HIV-1 Interacts with Human Endogenous Retrovirus K (HML-2) Envelopes Derived from Human Primary Lymphocytes
... ABSTRACT Human endogenous retroviruses (HERVs) are viruses that have colonized the germ line and spread through vertical ...frames. Expression of HERV-Ks has been linked to different pathological ... See full document
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Human endogenous retrovirus K (HML 2) RNA and protein expression is a marker for human embryonic and induced pluripotent stem cells
... are activated in ESC/iPSC/ECC lines in varying patterns We analyzed activation of HERV-K(HML-2) proviruses in malignant and non-malignant pluripotent stem cells using an established protocol ... See full document
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Identification of late assembly domains of the human endogenous retrovirus K(HML 2)
... with HIV and other viruses, overexpression of Tsg101 resulted in a moderate decrease of wild type re- lease that can be explained by a partial disorder of cellu- lar endosomal sorting pathways ... See full document
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HIV-1 Infection Leads to Increased Transcription of Human Endogenous Retrovirus HERV-K (HML-2) Proviruses In Vivo but Not to Increased Virion Production
... increased expression of HML-2 RNA in PBMCs from HIV-1-infected patients; however, they do not support the claim that HML-2 virions are present in ...of HML-2 ... See full document
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Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.
... Received 1 October 1996/Accepted 31 December 1996 The human endogenous retrovirus type K (HERV-K) family codes for the human teratocarcinoma-derived ... See full document
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Staufen-1 Interacts with the Human Endogenous Retrovirus Family HERV-K(HML-2) Rec and Gag Proteins and Increases Virion Production
... of HIV, it is conceivable that Staufen-1 already binds directly to the TAR element in the nucleus via its ...Staufen-1 expression was downregulated by shRNAs. Staufen-1 and Rec ... See full document
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Human endogenous retrovirus HERV K(HML 2) encodes a stable signal peptide with biological properties distinct from Rec
... and HML-2 SP are processed in the same ...to HML-2 type 2 proviruses argues for a vital role of SP in the former viral life ...that HML-2 SP served to back up or ... See full document
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Expression of the Human Endogenous Retrovirus (HERV) Group HML-2/HERV-K Does Not Depend on Canonical Promoter Elements but Is Regulated by Transcription Factors Sp1 and Sp3
... Sp3 protein binding to several GC boxes in the vicinity of the TSS, although the involvement of an Inr has often been postulated (31, 41, ...a retrovirus from a TATA-dependent to a TATA-independent ... See full document
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Human Endogenous Retrovirus K Gag Coassembles with HIV-1 Gag and Reduces the Release Efficiency and Infectivity of HIV-1
... if expression of HERV-K Gag is induced by HIV-1 infection, the HERV-K Gag might compete with HIV-1 Gag in the same host ...the HIV-1 release efficiency and ... See full document
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Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors
... IMPORTANCE Endogenous retroviruses are relics of ancestral virus infections in the human ...is activated in HIV-1- infected and cancer ... See full document
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Effects of the human immunodeficiency virus type 1 Tat protein on the expression of inflammatory cytokines.
... In this study, we have analyzed the effects of Tat on the expression of TNFa and TNFI, IL-la and IL-1p, and IL-6 during acute HIV-1 infection in T cells chronically infected with a pol-d[r] ... See full document
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Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase 1 in Tat activated HIV 1 transcription
... P-TEFb, Tat and TAR ...as Tat-induced HIV-1 transcription whereas inhibition of PP1 by recombinant nuclear inhibitor of PP1 (NIPP1) inhibited only Tat-induced transcription in ... See full document
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Inhibition of human endogenous retrovirus K by antiretroviral drugs
... by HIV‑1 RT inhibitors To determine the effects of RT inhibitors on HERV-K infection, we generated HERV-K viral particles with VSV-G pseudotype to facilitate infection of HERV-K in HeLa ... See full document
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Characterization of the human endogenous retrovirus K Gag protein: identification of protease cleavage sites
... accessory protein Rec with functional similarity to the HIV Rev protein ...gene expression is repressed in somatic cells; however, reactivation of HERV-K proviruses cod- ing for all ... See full document
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Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K–Related Sequences
... ABSTRACT Human endogenous retroviruses (HERV) make up 8% of the human ...HERV- K(HML-2), termed HK2, is able to code for all viral proteins and produce virus-like particles, it ... See full document
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Inhibition of human immunodeficiency virus type 1 and type 2 Tat function by transdominant Tat protein localized to both the nucleus and cytoplasm.
... full-length HIV-1 Tat protein and its functional domains (19, 28, 41, 57, 58) are shown in ...of Tat. To evaluate the ability of the mutant Tat proteins to activate HIV ... See full document
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Human immunodeficiency virus type 1 Tat upregulates interleukin-2 secretion in activated T cells.
... To investigate the effects of human immunodeficiency virus type 1 (HIV-1) Tat on interleukin-2 (IL-2) expression, we used IL-2 promoter-chloramphenicol acetyltransferase constructs and I[r] ... See full document
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Potent Inhibition of Human Immunodeficiency Virus Type 1 (HIV-1) Gene Expression and Virus Production by an HIV-2 Tat Activation-Response RNA Decoy
... Discussion. The vector for expressing the decoy presented in these studies has several benefits over other current anti-HIV gene therapy constructs. The RNA polymerase III promoter for U6 RNA is a highly ... See full document
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