[PDF] Top 20 Hsp40 Facilitates Nuclear Import of the Human Immunodeficiency Virus Type 2 Vpx-Mediated Preintegration Complex
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Hsp40 Facilitates Nuclear Import of the Human Immunodeficiency Virus Type 2 Vpx-Mediated Preintegration Complex
... with Hsp40/DnaJB6 by indirect immuno- fluorescence. Interestingly, the nuclear localization of Vpx was modulated by ...of Hsp40/ DnaJB6 increased Vpx nuclear accumulation, ... See full document
9
The C-Terminal Proline-Rich Tail of Human Immunodeficiency Virus Type 2 Vpx Is Necessary for Nuclear Localization of the Viral Preintegration Complex in Nondividing Cells
... PCR analysis of cellular DNA obtained immediately after infection gave no visible product (data not shown). Linear reverse transcription products, which were synthesized in the cytoplasm of infected cells, were amplified ... See full document
6
Nuclear Export of Simian Immunodeficiency Virus Vpx Protein
... Lentiviruses, human immunodeficiency viruses (HIVs), and simian immunodeficiency viruses (SIVs) are distinguished from oncoretroviruses by their ability to infect nondividing cells such as ...SIV ... See full document
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Nuclear Localization of Human Immunodeficiency Virus Type 1 Preintegration Complexes (PICs): V165A and R166A Are Pleiotropic Integrase Mutants Primarily Defective for Integration, Not PIC Nuclear Import
... each virus was released from transfected cells at the WT level, we focused our attention on the early steps of HIV-1 ...for nuclear localization because its LTR-LTR junction affords a convenient template ... See full document
10
Importin-α Promotes Passage through the Nuclear Pore Complex of Human Immunodeficiency Virus Type 1 Vpr
... the nuclear localiza- tion of PIC, is a small (14-kDa) nuclear protein of 96 amino acids that plays various roles in viral infection and cellular functions (6, ...the nuclear envelope (29, 54), but ... See full document
8
Novel Nuclear Import of Vpr Promoted by Importin α Is Crucial for Human Immunodeficiency Virus Type 1 Replication in Macrophages
... Nuclear import processes involve the nuclear pore com- plexes (NPCs) of the nuclear envelope and typically require nuclear localization signals ...The nuclear import of ... See full document
10
Interaction of Human Immunodeficiency Virus Type 2 Vpx and Invariant Chain
... Human immunodeficiency virus type 2 (HIV-2), like HIV-1, is a causative agent of AIDS, but it is limited in its geographical distribution primarily to West Africa (29, ...of ... See full document
5
Evidence for a Functional Link between Uncoating of the Human Immunodeficiency Virus Type 1 Core and Nuclear Import of the Viral Preintegration Complex
... Human immunodeficiency virus type 1 (HIV-1) particles begin their replication upon fusion with the plasma membrane of target cells and release of the viral core into the host cell ...the ... See full document
9
Vpx Is Critical for Reverse Transcription of the Human Immunodeficiency Virus Type 2 Genome in Macrophages
... the human immunodeficiency virus type 2 (HIV-2) group carry a vpx gene that encodes virion-associated Vpx ...protein. Vpx is an accessory viral protein and ... See full document
5
Nuclear Import of the Preintegration Complex Is Blocked upon Infection by Human Immunodeficiency Virus Type 1 in Mouse Cells
... the 2-LTR circular product to the late reverse transcription product (R-gag), which are produced in the nucleus and cytoplasm, respectively, was decreased in mouse splenocytes relative to human PBMCs after ... See full document
12
Nuclear Import Defect of Human Immunodeficiency Virus Type 1 DNA Flap Mutants Is Not Dependent on the Viral Strain or Target Cell Type
... the 2-LTR junction indicated a peak in copy number at 24 h postinfection for all wild-type viruses ...of 2-LTR copies per cell were detected at any time point postinfection, irrespective of the viral ... See full document
8
Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 Vpr.
... into virus-like parti- ...into virus-like particles, suggesting the importance of hydrophobic leucines in the helical domains for virion ...and nuclear local- ...for nuclear targeting is ... See full document
9
Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex
... Nucleoporins are not the first cellular proteins to have been molecularly identified as interacting partners for HIV-1 Vpr. Recent studies have shown that two proteins associated with DNA repair, uracil DNA glycosylase ... See full document
10
Human Immunodeficiency Virus Type 1 Modified To Package Simian Immunodeficiency Virus Vpx Efficiently Infects Macrophages and Dendritic Cells
... chimeric virus on MDM ...the Vpx packaging motif has an enhanced ability to infect MDDC and ...of Vpx provided in ...reporter virus plasmid (18 g) and increasing amounts of ...myc-tagged ... See full document
12
Evaluation of the Functional Involvement of Human Immunodeficiency Virus Type 1 Integrase in Nuclear Import of Viral cDNA during Acute Infection
... of 2-LTR DNA, a surrogate marker for nuclear import, produced by the PYNP⬎KL mu- tant was only ⬃3% that produced by the catalytic site mutant ...of 2-LTR DNA was also noted for the N144Q and ... See full document
11
Localization of the Vpx packaging signal within the C terminus of the human immunodeficiency virus type 2 Gag precursor protein.
... Using 35S labeling and radioanalytic imaging analysis, we confirmed our Western blot data and demonstrated that HIV-2 wild-type pGT-2gag and chimeric expression plasmids containing HIV-2[r] ... See full document
9
Preadaptation of Simian Immunodeficiency Virus SIVsmm Facilitated Env-Mediated Counteraction of Human Tetherin by Human Immunodeficiency Virus Type 2
... progeny virus release and spread of infection within and between individuals (23, ...and human endogenous retroviruses, also use their envelope glycoproteins to counteract tetherin-mediated ... See full document
24
The Barrier-to-Autointegration Factor Is a Component of Functional Human Immunodeficiency Virus Type 1 Preintegration Complexes
... (lane 2), fraction II (lane 4), and unbound SB fractions (lanes 10 and ...was mediated by specific interactions between an- ...lanes 2, 4, and 7 to 12. Whereas fraction I was analyzed in lanes 1 and ... See full document
7
Enhancement of human immunodeficiency virus type 1 envelope-mediated fusion by a CD4-gp120 complex-specific monoclonal antibody.
... of human immunodeficiency virus type 1 (HIV-1) into cells is initiated by binding of the viral gly- coprotein gp120-gp41 to its cellular receptor ...gp120-CD4 complex formed at the cell ... See full document
7
Human Immunodeficiency Virus Type 1 Entry into Macrophages Mediated by Macropinocytosis
... for 2 h at ...remove virus adsorbed at the cell surface, cells were then treated for 2 min with 1 mg of pronase (Boerhinger Mannheim)/ml in ice-cold RPMI and 20 mM ... See full document
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