[PDF] Top 20 The fading of reported effectiveness. A meta-analysis of randomised controlled trials

... its reported effect size, even though there was a strong correlation between publication year and treat- ment group (Table ...regression analysis models (Table ... See full document

... Figure 3 presents scenarios that may occur when com- bining RCTs and non-randomized studies in NMA. In some cases (e.g., drug B versus drug A), findings from non-randomized studies align with those reported in ... See full document

... few meta-analyses investigating the treat- ment effects of KT [6–10]. A meta-analysis conducted by Chang et ...al. reported that KT can relieve pain and in- crease the flexibility of muscles ... See full document

... Nutrition and Dietetics Quality Criteria Checklist for Primary Research [33]. Cochrane suggests, it is prefera- ble to use simple approaches for assessing validity that can be fully reported (i.e. how each trial ... See full document

... this meta-analysis is to compare the effectiveness of the Lumbar Interbody Fusion techniques (specifically Posterolateral Interbody ap- proach—PLIF) versus Posterolateral Instrumented Fusion ...this ... See full document

... Methods English (PubMed, Embase, Cochrane Library, PsycINFO) and Chinese (Chinese National Knowledge Infrastructure, Wanfang Data) databases were systematically searched up to 10 June 2018. The inclusion criteria were ... See full document

... There have been several descriptive, non-systematic safety re- views of naltrexone recently [37, 38], but none to date have concentrated on AEs and SAEs in clinical trials of naltrexone. Including studies from a ... See full document

... Eligible studies were reviewed and the following data were abstracted: (1) first author’s name; (2) year of publi- cation; (3) country where the study was performed; (4) study design; (5) number of participants in the ... See full document

... Only one study made a positive claim for its intervention after 5 years 18 and subsequently, this was moderated. 19 Rose et al 14 warned of possible harm by administering corn oil. The Research Committee 15 concluded “ A ... See full document

... inadequately controlled with current therapy; 2) reported outcome of percentage of patients achieving A 1C < 7% target; 3) provided mean change in A 1C from baseline with standard error or 95% confidence ... See full document

... the effectiveness of acupuncture for episodic migraine has been confirmed by multiple clinical trials and Cochrane systematic reviews, the mechanisms underlying the specific effect of acupuncture for ... See full document

... studies reported greater than 20% dropout in the intervention arm raises questions about the relevance and appropriateness of the interventions for survi- ... See full document

... RCT meta-analysis population and was comparable also in age, gender and left ventricular (LV) function (73% male, mean age ...separately reported. A com- parison of the complication rates ... See full document

... prospective, randomised controlled trials (RCTs) and comparative observational studies with no lan- guage restriction if they enrolled participants diagnosed with intertrochanteric fractures and ... See full document

... and meta-analysis of published randomised controlled trials (RCTs) was conducted to review the effectiveness of current chemopreventive agents in the treatment of oral ... See full document

... the effectiveness of the interventions, a meta-analysis was not feasible for making estimates of strength of effect due to variations in intervention components, outcome mea- sures, follow up times ... See full document

... Our analysis of the treatment trials also supports this ...been reported as an effective treatment strategy for pro- nation ...other trials reviewed did not attempt to provide a matched ... See full document

... With advances in diagnostic modalities, such as mammography, ultrasonography, and magnetic resonance imaging, the breast tumors with a diameter of 1 cm could be detected. Therefore, surgical treatment for breast cancer ... See full document

... The studies contained predominantly mixed populations of colonic and rectal procedures, with inadequate documentation to differentiate results between the two, which may be particularly important in addressing the ... See full document

... previous meta-analyses have important implications for ...cost- effectiveness data as well as substantial between-study heterogeneity in both meta-analyses [30,37], exercise ap- pears to improve ... See full document