[PDF] Top 20 Fibrates for the treatment of cholestatic itch (FITCH): study protocol for a randomized controlled trial

... placebo treatment (ratio 1:1) as per a computer-generated randomization sched- ule with randomly varying block sizes (maximum block size of 4) by the sites’ investigator through a web-based module written in ALEA ... See full document

... metformin treatment are being selected along several genes: the ataxia telangiectasia mutated ( ATM , rs11212617); the glucoki- nase regulatory protein ( GCKR , rs1260326); the serine- threonine kinase 11 ( STK11 ... See full document

... Absolute values of continuous variables will be expressed using standard summary statistics, arithmetic mean, standard deviation, and corresponding 95 % confidence interval. The study is designed to compare ... See full document

... According to the definition of the clinical, etiological, ana- tomical, and pathological classification (CEAP), the reticular veins are included in the C1 class and are mainly associated with aesthetic complaints. ... See full document

... periodontal treatment can reduce serum inflammatory biomarkers such as C-reactive protein, or erythrocyte sedimentation ...its treatment would improve RA outcomes. The aim of this clinical trial is ... See full document

... Randomized clinical trials have shown that nonsurgical PT (oral hygiene counseling, scaling, polishing and root planing) leads to a significant reduction in plasma levels of acute-phase proteins, such as ... See full document

... DASH-RCT trial is a randomized, double blind, placebo-controlled trial designed per the Standard Protocol Items: Recommendation for Interventional Trials (SPIRIT) and Consolidated ... See full document

... with study medicine or ECT will be included in the analysis of the safety, demographic and baseline charac- teristic ...of treatment-emergent adverse events will be ...with study medicine and provide ... See full document

... antidepressant treatment to see if scopolamine could accelerate the onset of antidepressant ...the treatment of severe MDD, showing the promise of speeding up early oral antidepressant efficacy ... See full document

... restorative treatment for DOC, neurostimulation has attracted increasing ...A study of thalamic deep brain stimulation demonstrated a remarkable behavioral recovery in patients with TBI ... See full document

... Trials) Study Flow Chart for this ...five treatment subscales can be derived from the SRS: Social Awareness, Social Cognition, Social Com- munication, Social Motivation, and Autistic ... See full document

... to trial conduct or other ethical and safety issues ...the trial, the analysis report will be circulated to Principal Investigators, DSMB, Ethics Committees, Ministries of Health and Drug Regu- latory ... See full document

... the trial, participants will be visited at baseline and on the fourth day post base- line (see ...The study protocol complies with Standard Protocol Items: Recommendations for Interventional ... See full document

... for RA, were diagnosed with another inflammatory dis- ease within one month of screening, or experienced uncontrolled or clinically significant systemic disease other than RA. Patients diagnosed with class IV RA as ... See full document

... our treatment centers and has sustained a physical injury during the motor vehicle ...(UHN) trial coordinator who will arrange an appointment at the nearest study clinic to assess the claimant's ... See full document

... This study has been approved for human subject research by the Stanford University IRB (reference number 22436) and undergoes routine review and resubmissions to the appropriate ...This trial is registered ... See full document

... Psychosocial distress in cancer patients causes significant financial and emotional costs. It is associated with high utilization of health services, low quality of life and in- creased mortality [1,2]. Meta-analyses ... See full document

... 5. Adverse events (AEs), such as signs and symptoms and other ailments, will be documented at every visit. Every AE will be described as a mild, moderate, or severe AE, and association with the intervention drugs will be ... See full document

... beneficial treatment. More mod- erate evidence in a nonrandomized study showed a decrease in depressed mood [4] or reduced pain after biofield therapies in populations with cancer ...the treatment of ... See full document

... This protocol is presented in accordance with the 2013 SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) Statement (see Additional file 1 for the populated SPIRIT Checklist and ... See full document