[PDF] Top 20 Foamy Virus Envelope Glycoprotein-Mediated Entry Involves a pH-Dependent Fusion Process
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Foamy Virus Envelope Glycoprotein-Mediated Entry Involves a pH-Dependent Fusion Process
... the pH dependence of the different FV Envs, with PFV being the only FV Env having a significant fusion activity at neutral ...a pH-independent mechanism also, at least to some ...a ... See full document
10
Role of Endosomal Cathepsins in Entry Mediated by the Ebola Virus Glycoprotein
... Ebola virus glycoprotein (GP) is a class I viral fusion protein composed of a receptor binding subunit (GP1) and a fusion subunit (GP2) that are linked by a disulfide ...viral fusion ... See full document
5
Mutagenesis of the fusion peptide-like domain of hepatitis C virus E1 glycoprotein: involvement in cell fusion and virus entry
... The entry of both HCVpp and HCVcc is mediated by E1 and E2 in a pH-dependent manner ...membrane fusion event, where the viral envelope fuses with an endosomal membrane by an as ... See full document
18
An Antibody Directed against the Fusion Peptide of Junín Virus Envelope Glycoprotein GPC Inhibits pH-Induced Membrane Fusion
... For fusion inhibition to occur, MAb F100G5 must bind within the time frame of the pH-induced structural ...the fusion peptide is only transiently exposed in productive membrane fusion, then ... See full document
11
Host cell virus entry mediated by Australian bat lyssavirus G envelope glycoprotein occurs through a clathrin mediated endocytic pathway that requires actin and Rab5
... low pH-dependent fusion ...pathways mediated either by clathrin or macropinocytosis, but several alternative path- ways have been reported (reviewed in ...for entry and the endocy- tic ... See full document
10
Intersubunit Interactions Modulate pH-Induced Activation of Membrane Fusion by the Junín Virus Envelope Glycoprotein GPC
... acidic pH and, thereby, in pH-dependent membrane fusion (44, ...in pH-triggered activa- tion, the subsequent mechanics of GPC-mediated membrane fusion are likely similar ... See full document
6
Stoichiometry of Envelope Glycoprotein Trimers in the Entry of Human Immunodeficiency Virus Type 1
... with virus entry may require distinct structural features in the viruses and/or recep- ...membrane fusion (56, 80). During the pH-dependent entry process utilized by ... See full document
16
Role of the Stable Signal Peptide of Junín Arenavirus Envelope Glycoprotein in pH-Dependent Membrane Fusion
... the envelope glycoprotein (GP-C) mediates entry of the virus into the host cell and is the primary target for virus-neutraliz- ing antibodies (24, 44), there have been extensive efforts ... See full document
6
The CD4-independent tropism of human immunodeficiency virus type 2 involves several regions of the envelope protein and correlates with a reduced activation threshold for envelope-mediated fusion.
... immunodeficiency virus type 2 (HIV-2) strains have been shown to infect some CD4-negative cell lines ...the envelope protein which are required for CD4-independent ...cell-cell fusion, suggesting ... See full document
13
Mildly Acidic pH Triggers an Irreversible Conformational Change in the Fusion Domain of Herpes Simplex Virus 1 Glycoprotein B and Inactivation of Viral Entry
... simplex virus (HSV) causes a wide array of human infections resulting in significant morbidity and mortality ...enveloped virus and therefore must fuse with a host cell membrane to initiate entry and ... See full document
12
Small-Molecule Fusion Inhibitors Bind the pH-Sensing Stable Signal Peptide-GP2 Subunit Interface of the Lassa Virus Envelope Glycoprotein
... arenavirus envelope glycoprotein (GPC) have recently been identified and shown to block GPC-mediated fusion of the viral and cellular endosomal membranes, thereby preventing virus ... See full document
9
Inhibition of Human Immunodeficiency Virus Envelope Glycoprotein- Mediated Single Cell Lysis by Low-Molecular-Weight Antagonists of Viral Entry
... F522Y/L523S envelope glyco- proteins, respectively (Fig. 1A). These envelope glycoprotein variants have alterations in the gp41 fusion peptide that, re- spectively, diminish or eliminate ... See full document
7
Low-pH conformational changes of rabies virus glycoprotein and their role in membrane fusion.
... This effect on the fusion curves was still observed when the virus was preincubated with liposomes at pH 6.7 and 0°C data not shown, whereas a preincubation at pH 7.3 and 0°C did not mod[r] ... See full document
8
Role of the Membrane-Proximal Domain in the Initial Stages of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein-Mediated Membrane Fusion
... Simian virus 40-based env expression plasmids (1 mg) containing WT (A to D), W(1-5)A (E to H), and 1DAF (I to L) env genes were transfected into COS-1 cells in 35-mm plates using DEAE-dextran (1 ...of ... See full document
5
Characterization of Glycoprotein-Mediated Entry of Severe Fever with Thrombocytopenia Syndrome Virus
... tion and the growth of SFTSV were particularly inhibited by 25HC in a dose-dependent manner in both Vero and Huh7 cells (Fig. 7A and B). These results indicated that 25HC mainly affected SFTSV cell entry. ... See full document
10
Identification of Novel Functions for Hepatitis C Virus Envelope Glycoprotein E1 in Virus Entry and Assembly
... CD81 interaction and immunoprecipitation assays. CD81 pulldown and immunoprecipitation experiments were performed as previously described (59). Cells were lysed in PBS lysis buffer (1% Triton X-100, 20 mM NEM, 2 mM EDTA, ... See full document
19
A 45,000-M(r) glycoprotein in the Sendai virus envelope triggers virus-cell fusion.
... HIV envelope form an “adhesion patch” preceding the virus-cell fusion ...membrane fusion induced by the HIV-1 envelope (15, 16). Mem- brane fusion is believed to be triggered by ... See full document
9
Calcium ions are required for cell fusion mediated by the CD4-human immunodeficiency virus type 1 envelope glycoprotein interaction.
... To examine the role of calcium ions for cell fusion mediated by interactions between CD4 and the human immunodeficiency virus type 1 HIV-1 envelope glycoprotein gpl20-gp4l, we used two e[r] ... See full document
6
Envelope glycoprotein gp50 of pseudorabies virus is essential for virus entry but is not required for viral spread in mice.
... 67, 1993 gp5O PhCMV, gX gp63 G5 cells StuI gp63 BstXI BglII gp5O Ii R122 t R332 t M102 M105 PRV genome linker insertion mutants D1200 deletion mutant D560 deletion mutant mutants are let[r] ... See full document
8
The role of cholesterol and sphingolipids in chemokine receptor function and HIV 1 envelope glycoprotein mediated fusion
... HIV-1 entry we asked the question whether similar lipid modu- lation would affect HIV-1 entry/fusion when we consider just one receptor required for ... See full document
8
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