[PDF] Top 20 Function and clinical significance of circRNAs in solid tumors

... correlated with the prognosis of patients with glioma. In addition, hsa_circ_022705 encodes the FBXW7-185aa protein. Upregulation of FBXW7-185aa significantly in- hibits the proliferation of tumor cells, while silencing ... See full document

... In solid tumors, PDCD4 expres- sion was inhibited by the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT)/mammalian target of rapamycin (mTOR) ...of solid tumor development and further ... See full document

... might function as pre-existing driver “ hits ” , which together with acquired complementary somatic mutations would act to dysregu- late key pathways in malignant transformation ... See full document

... SSR study was carried out according to the techni- cal standards of the International Federation of Clinical Neurophysiology [40]. During the test, subjects were kept relaxed with comfortable light and temperature ... See full document

... many anticancer drugs are highly lipophilic and rela- tively small, the permeation level of those drugs across the BBB is unexpectedly low [3]. This can be partially explained by the expression of P-glycoprotein (P-gp) ... See full document

... It is rational to suggest that surgery remains the cor- nerstone of the treatment of all resectable nonlymphoma tumors. Adjuvant therapy should target the more advanced or aggressive tumor type [40, 41]. The issue ... See full document

... is reduced; failure to repair the damage completely results in an ongoing accumulation of DNA lesions resulting in the continuous growth of tumor cells. However, as the tumor progresses, the NER repair capacity becomes ... See full document

... CCND1, also known as BCL1, encodes a highly con- served cyclin protein, which exerts regulatory functions on CDK kinases. Mutation, amplification, and overexpression of CCND1 alter cell cycle progression, which might ... See full document

... on solid tumors remains ...in solid tumors; hence, G6PD overexpression can be an independent predictor for unfavorable all-cause mortality and cancer progression in patients with solid ... See full document

... Lack of a reliable biomarker to predict prognosis is a main hurdle to realize individualized treatment. Fortunately, emerging data favor the potential use of miR-100 as a cancer prognostic predictor. In recent years, ... See full document

... malignant tumors. 13 Increasing evidence has indicated that circRNAs play a crucial role including carcinogenesis, progression and clinical outcomes of various human ...could function as a ... See full document

... To our knowledge, this meta-analysis is the most thor- ough appraisal of the clinical studies that investigated the prognostic value of NANOG expression in human solid tumors. Thirty-three eligible ... See full document

... confirmed by two senior pathologists, and cases without consensus were identified by the third pathologist. In addition, in the validation cohort, 49 patients presented good response to the neoadjuvant chemotherapy ... See full document

... When it came to therapies, there was no significant dif- ference in DFS or OS between patients receiving a modified radical or radical/extended radical mastectomy (P = 0.2454 and P = 0.6428, respectively). To investigate ... See full document

... To our knowledge, this study is the first to identify the role of circRNA000390 in CRC. Our findings showed that circRNA0003906 expression level was significantly downregulated in both CRC tissues and CRC cell lines. It ... See full document

... the clinical ef fi cacy of therapeutic ...of solid tumors and their microenvironment that affect tumor penetration and distribution is a key requirement to improve clinical outcomes and realize ... See full document

... Previous studies have showed that both the expression of fascin-1 and laminin-5 were associated with the invasiveness and prognoses of several cancers, including colorectal (Adams, 2015; Fukazawa et al., 2015), gastric ... See full document

... biological significance is yet to be established. Like other MTs, MT-3 may function as a metal detoxicant, but may also inhibit neurite outgrowth and promote neuronal death by serving as a source of toxic ... See full document

... static disease is the main cause of mortality and morbidity. Metastasis is a complex process requiring tumor cells to invade the surrounding tissue, gain access to the vasculature, survive transport, exit the ... See full document

... detailed clinical, histopalthological and radiological investigations and were treated ...common tumors in our study (33%) followed by pseudotumor (25%) and hemangiomas ...Malignant tumors accounted ... See full document